Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Capsules Using Pelletization Technique
Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit…
Lignin and Cellulose Blends as Pharmaceutical Excipient for Tablet Manufacturing via Direct…
Extensive efforts are being made to find alternative uses for lignin (LIG). In the present work the use of this biopolymer as an excipient to prepare tablets was studied.
For this purpose, LIG was combined with microcrystalline cellulose…
Improvement of tabletability via twin-screw melt granulation: Focus on binder distribution
In this study, the impact of binder distribution on the tabletability and compactibility of granules produced by twin-screw melt granulation was investigated.
To this end, two grades of dicalcium phosphate anhydrous (fine and coarse)…
The Role of Particle Surface Area and Adhesion Force in the Sticking Behavior of Pharmaceutical…
The effect of particle surface area and adhesion force on sticking behavior for a model pharmaceutical blend was studied.
Various lots of an active pharmaceutical ingredient (API) differing in particle size distribution and surface area…
Encapsulation of Isoniazid-conjugated Phthalocyanine-In-Cyclodextrin-In-Liposomes Using Heating…
Liposomes are reputed colloidal vehicles that hold the promise for targeted delivery of anti-tubercular drugs (ATBDs) to alveolar macrophages that host Mycobacterium tuberculosis.
However, the costly status of liposome technology,…
Predicting physical stability of solid dispersions by machine learning techniques
Amorphous solid dispersion (SD) is an effective solubilization technique for water-insoluble drugs.
However, physical stability issue of solid dispersions still heavily hindered the development of this technique. Traditional stability…
Influence of the particle size of copovidone and crospovidone on tablet characteristics
Copovidone and crospovidone are commonly used excipients in solid oral dosage forms for many decades. Typically, copovidone is used as dry binder and crospovidone as disintegrant in tableting formulations. The use of dry binder and…
Assessing the Utility of In Vitro Screening Tools for Predicting Bio-Performance of Oral Peptide…
Purpose
In this study we evaluated the utility of in-vitro screening tools for predicting the in-vivobehavior of six cyclic peptides with different solubility and permeability properties (BCS class II and III), intended for oral delivery…
The physical stability of drugs linked to quality-by-design (QbD) and in-process technology (PAT)…
The physical stability of solid-state forms in which drugs may exist is in some sense an overlooked aspect.
In an era where strategies such as amorphous solid dispersions or co-amorphous preparations might provide answers to stumbling…
Continuous twin screw granulation: Impact of the starting material properties and various process…
The purpose of this study is to confirm the correlation between the formulation factors and the process parameters using multivariate analysis (MVA) during twin screw granulation.
Various grades of lactose and MCC were used as starting…
A brief review on Kollidon
Polyvinylpyrrolidone includes soluble and insoluble grades; soluble grades are synthesised by the mechanism of polymerization, the free radical polymerization into water by using hydrogen peroxide as an initiator, the mechanism which…
Real time MRI to elucidate the functionality of coating films intended for modified release
Polymer films based on mixtures of ethyl cellulose (EC) and hydroxypropyl cellulose (HPC) have been widely used to coat pellets and tablets to modify the release profile of drugs.
For three different EC/HPC films we used 1H and 19F MRI…
3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles.
In order to obtain controllable release profiles, three types of tablet…
Common Tableting Problems
Dr. Frank Oprach speaks about common problems encountered during tableting.
MORE ON BASF PHARMACEUTICAL EXCIPIENTS
Targeted delivery in food supplements: why it matters and how to apply it
This Controlled Release Society TechForum presentation by Dr. Miriam Robota (Evonik Nutrition & Care) explains the use and possibilities of EUDRAGUARD in nutraceutical coatings. Have a look at the video
or download the…
Labrasol® is an efficacious intestinal permeation enhancer across rat intestine: Ex vivo and in vivo…
Labrasol® ALF (Labrasol®), is a non-ionic surfactant excipient primarily used as a solubilising agent.
It was investigated here as an intestinal permeation enhancer in isolated rat colonic mucosae in Ussing chamber and in rat in situ…
Resins That Allow Distinctive Drug Delivery Solutions – POLYOX™ product information
POLYOX™ resins are nonionic poly (ethylene oxide) polymers. They are white to off-white, free-flowing hydrophilic powders supplied in a wide variety of viscosity grades corresponding to approximate molecular weight, ranging from 100,000 to…
Formulation of Chlorpheniramine maleate tablets using co-processed excipient as a filller and binder
Co-Processed Excipient (CPE) is technological innovation for tablet preparation through the direct compression method with a quick and straightforward manufacturing process.
This research aimed to formulate and evaluate tablets prepared…
Characterising Glass Transition Temperatures and Glass Dynamics in Mesoporous Silica-Based Amorphous…
In this study the glass transition temperatures (Tgα and Tgβ) in mesoporous silica-based amorphous drugs were characterized.
For this purpose, mesoporous silica Parteck SLC (MPS) was loaded with the drugs ibuprofen and carvedilol, either…
Effect of coating time on inter- and intra-tablet coating uniformity
Film tablets are a common oral dosage form. For many of the functions film layers can have on pharmaceutical tablets, a high degree of coating uniformity is required.
In studies on coating uniformity the coefficient of variation is…
Nanocarrier Lipid Composition Modulates the Impact of Pulmonary Surfactant Protein B (SP-B) on…
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs.
Nevertheless, the widespread use of siRNA is limited…
Microencapsulation for Delivery of Probiotic Bacteria
In this era of modernization and hectic lifestyles, consumers demand functional foods providing nutrients with physiological and health benefits.
Probiotics belong to this in-demand category of functional and nutraceutical foods.…
Measurement of granule layer thickness in a spouted bed coating process via optical coherence…
In this work a recently developed in-line measurement technique for monitoring of coating thickness was applied to a spray-coating process in a three-dimensional prismatic spouted bed.
The layer thickness was quantified with an optical…
A novel method of quantifying the coating progress in a three-dimensional prismatic spouted bed
An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented.
Microcrystalline cellulose particles (Cellets) with size dp = 0.57 mm are used as core material. Waterborne coating…
Determining the minimum amount of Kollidon® SR required in a tableting blend to obtain a matrix…
Kollidon® SR-based matrix formulations are well known for obtaining strong sustained release functionality. Depending on the solubility of the active ingredient and the required dissolution profile, pore formers need to be added for…
Development of sublingual spray formulation containing ondansetron hydrochloride dihydrate
Ondansetron is an antiemetic agent which is used primarily in hospital settings to prevent nausea and vomiting while patient is on chemotherapy or radiotherapy.
Oral tablets currently available in the market exhibit a rather slow onset…
Trends in Instant- and Modified- Release Dosage Forms
Dr. Rainer Dobrawa talks about some current trends in instant- and modified-release formulations at a BASF symposium in Ludwigshafen, Germany.
More on BASF…
A fast strategy for profiling and identifying pharmaceutic excipient polysorbates
Polysorbates, a group of nonionic surfactants, are widely used as pharmaceutic excipient.
Their quality and safety are closely related to their profiles, including composition, structure, proportion and polyoxyethylene (POE)…
Characterization of spray dried powders with nucleic acid-containing PEI nanoparticles
Localized aerosol delivery of gene therapies is a promising treatment of severe pulmonary diseases including lung cancer, cystic fibrosis, COPD and asthma. The administration of drugs by inhalation features multiple benefits including an…
Multi-dose oral abuse deterrent formulation of Loperamide using Hot melt extrusion
Loperamide, an over the counter anti-diarrheal drug, also infamously referred to as “poor man's methadone”.
Due to the ease of availability and low price, people/patients abuse it by consuming more than 30 tablets to achieve euphoric…
Potential Formulation Option: Pellets
Thorsten Cech talks at a BASF symposium in Ludwigshafen, Germany about how using a mixture of different pellets with various release kinetics can benefit a formulation.
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Novel lipid-based drug delivery systems containing polymethacrylate polymers as solid carriers for…
Formulation of lipid-based drug delivery systems is recognized as a promising strategy to increase bioavailability of simvastatin (SV).
The purpose of this study was to formulate advantageous lipid-based drug delivery systems for…
Say good-bye to greasy and sticky topical medicines: Solutions and inspirations for sensorial…
It is widely recognised that patient adherence to topical drugs is low because of the complexity or inconvenience of the treatment regimen1 (difficult self- application, number of applications, time consumption, etc.). This leads to poor…
Combining directly compressible Ibuprofen DC 85 W with different caffeine grades and investigating…
Ibuprofen is a very challenging product in direct compression. Due to its low melting point and unfavourable particle shape, there are many problems (e.g. sticking) that might occur during tabletting.
However, Ibuprofen DC 85 W as a…
Developments in encapsulation of insulin: Is oral delivery now possible?
This review presents the possibilities of oral delivery of insulin.
Insulin, being readily destroyed/transformed by the proteolytic enzymes and first-pass effects in the digestive system, has mainly been administered through injection,…