Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Combining directly compressible Ibuprofen DC 85 W with different caffeine grades and investigating…
Ibuprofen is a very challenging product in direct compression. Due to its low melting point and unfavourable particle shape, there are many problems (e.g. sticking) that might occur during tabletting.
However, Ibuprofen DC 85 W as a…
Developments in encapsulation of insulin: Is oral delivery now possible?
This review presents the possibilities of oral delivery of insulin.
Insulin, being readily destroyed/transformed by the proteolytic enzymes and first-pass effects in the digestive system, has mainly been administered through injection,…
OSD Academy in Düsseldorf – September 24, 2019 – join us!
The OSD Academy is getting closer and the agenda of the day has been settled. For that we would like to give you a short outlook how your experience will look like. That is how the Formula of the Day will look like:
9:30 Reception…
Fluidbed Technology for the coating of powders, pellets and micropellets – an educational…
This educational booklet from Glatt gives a great insight on the technologies and processes to coat powders, pellets and micropellets.
Introduction
Fluid bed processes were originally used in chemical process technology. Fluid bed…
Potential for pharmaceutical excipients to impact absorption: A mechanistic review for BCS Class 1…
The potential for certain excipients to impact drug absorption is the subject of numerous publications.
Reflecting this, current Biopharmaceutics Classification System (BCS) guidelines place restrictions on the level of change in…
Design and evaluation of rhubarb total free anthraquinones oral colon-specific drug delivery…
Rhubarb is commonly used as a cathartic in Asian countries. However, researchers have devotedextensive concerns to the quality control and safety of rhubarb and traditional Chinese preparations composed of rhubarb due to the instable…
Microparticles, Microspheres, and Microcapsules for Advanced Drug Delivery
Microparticles, microspheres, and microcapsules are widely used constituents of multiparticulate drug delivery systems, offering both therapeutic and technological advantages.
Microparticles are generally in the 1–1000 μm size range,…
Key Trend: Continuous Manufacturing
Dr. Valerie Vanhoorne presents the advantages of continuous manufacturing at a BASF symposium in Ludwigshafen, Germany.
MORE ON BASF
Evaluation of size-based distribution of drug and excipient in amphotericin B liposomal formulation
Conventional quantitation of drug content in the liposome formulation involves the breakdown of bulk liposomes, which ignores details on the distribution of the active pharmaceutical ingredient (API) and excipients in liposomes of different…
Terahertz Spectroscopy: An Investigation of the Structural Dynamics of Freeze-Dried Poly…
Biodegradable poly lactic-co-glycolic acid (PLGA) microspheres can be used to encapsulate peptide and offer a promising drug-delivery vehicle.
In this work we investigate the dynamics of PLGA microspheres prepared by freeze-drying and…
Titanium-Free Food Color Alternatives Market to Witness a Healthy Growth during 2019-2029
The growing trend for natural and organic food color is resulting in shift from titanium dioxide, a synthetic ingredient, towards titanium-free food color alternatives and extracting food colors from alternative natural sources. Natural…
Acoustic Cavitation-Assisted Formulation of Solid Lipid Nanoparticles using Different Stabilizers
Because of excellent bioavailability and high biocompatibility, solid lipid nanoparticles (SLNs) have gained attention in recent years, especially in drug delivery systems.
SLNs are composed of a drug that is loaded in a lipid matrix and…
JRS PHARMA is pleased to announce cDMF filings with the NMPA for many of their excipient products…
As one of the industry leaders in excipient solutions, JRS PHARMA strives for global regulatory compliance. In order to manufacture and sell pharmaceutical products in China, all ingredients must have a Chinese Drug Master File (cDMF). JRS…
Oromucosal films: From patient centricity to production by printing techniques
Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredients have been…
Gattefossé – New Suppocire® grades for flexibility and high performance
Learn how Suppocire® NAI 25 A improves dispersion and dissolution of solid API such as diclofenac sodium and other anti-inflammatory drugs. Discover how Suppocire® AGP improves dispersion and stability of waxy/liquid APIs, eg traditional…
Measure thickness, roughness and homogeneity of a film coating?
With OSeeT by Phyllon you can get up to 400 images of pellets in one minute and you can measure thickness, roughness and homogeneity of the filmcoating. For single layer, multi-layers, in-line or at-line, for pellets, mini-tablets, tablets,…
Development and evaluation of synchronized and sustained release Tripergium Wilfordii tablets based…
Development of synchronized and sustained release preparations for herbal medicines is still a vast challenge due to their complicated components with different physicochemical properties.
In this study, tablets were developed to achieve…
Electrospun amorphous solid dispersions of meloxicam: Influence of polymer type and downstream…
The objectives of this work were to develop meloxicam based amorphous solid dispersion through electrospinning technique and evaluate the effect of the polymeric matrix on the physicochemical properties of the fibers and the downstream…
A contact model for the deformation behaviour of pharmaceutical pellets under cyclic loading
Spherical pharmaceutical pellets are commonly produced by an extrusion-spheronization process. In the spheronizer, the wet cylindrical extrudates are rounded into spheres due to multiple collisions.
In order to model this rounding, a…
Electrospun oral formulations for combined photo-chemotherapy of colon cancer
In this work, we report new formulations for the combined photo-chemotherapy of colon cancer.
Fibers were fabricated via coaxial-electrospinning with the intent of targeting delivery of the anti-cancer drug carmofur (CAR) and the…
Externally Addressable Smart Drug Delivery Vehicles: Current Technologies and Future Directions
Growing clinical evidence around the value of delivering drugs with pulsatile, user-controlled, or patient-specific kinetics has recently resulted in extensive efforts toward the design of new functional materials that can enable on-demand…
Tablet capping predictions of model materials using multivariate approach
The present study demonstrated the prediction of predominant root causes of capping behavior as a function of the powder rheological and the mechanical behavior of Acetaminophen (APAP) and Ibuprofen (IBU).
The authors analyzed powder…
List of drugs that need generic alternatives shared by USFDA and China
In its continuous endeavor to bolster the competitiveness of the generics market, the US Food and Drug Administration (FDA) updated its list of ‘off-patent, off-exclusivity drugs without an approved generic’. This update is part of FDA’s…
Development of a safe and versatile suspension vehicle for pediatric use
This project aimed to develop a suspension vehicle specifically designed for pediatric use. Excipients were selected according to their safety and recorded use in pediatrics. Two suspension vehicles were formulated at neutral and acidic pH.…
Review Topical Inserts: A Versatile Delivery Form for HIVPrevention
The development of topical inserts for the prevention of sexually transmitted infections (STIs), particularly human immunodeficiency virus (HIV), represents a promising alternative to oral and parenteral pre-exposure prophylaxis (PrEP)…
Expedited investigation of powder caking aided by rapid 3D prototyping of testing devices
Powder caking can dramatically affect powder handling and downstream production processes. Understanding the key factors that contribute to bulk powder caking are crucial.
This paper introduces the Hirschberg caking device (HCD), which…
FDA publishes guidance for Inactive Ingredient Database
The US Food and Drug Administration (FDA) has released draft guidance for public consultation on the use of the Inactive Ingredient Database (IID). The document is intended to provide information on how to use the IID when choosing inactive…
Comparison of the coating process and in vitro dissolution of 3 mm gastro-resistant minitablets and…
Minitablets are solid oral forms, which, due to their size (1-3 mm), may be easily swallowed by children.
The administration of minitablets in a certain number of units allows for flexible dosing for a broad age group of paediatric…
Taste masked natural caffeine
The bitter taste of caffeine can be a challenge especially in orally dispersible or liquid dosage forms. In both cases a taste masking by coating or encapsulation of the caffeine can be an effective way to achieve the desired result and…
Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability
Enteric coating is a common procedure in the development of oral pharmaceutical dosage forms.
The main advantage of enteric coating is that it protects the drug from acidic pH and enzymatic degradation in the stomach while protecting it…
Glutathione-Loaded Solid Lipid Microparticles as Innovative Delivery System for Oral Antioxidant…
The present study aimed to develop a novel formulation containing glutathione (GSH) as an oral antioxidant therapy for the treatment of oxidative stress-related intestinal diseases.
To this purpose, solid lipid microparticles (SLMs) with…
Optimization and characterization of rivastigmine nanolipid carrier loaded transdermal patches for…
The present study aimed to develop nanolipid carrier (NLC) loaded transdermal system of rivastigmine for bioavailability enhancement. NLC was optimized using Box-Behnken Design (BBD). Optimized formulation comprises oil (4% w/w), tween 80…
Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance…
The objective of this study was to investigate the applicability of water-insoluble polymers as binders for pellets drug layering to extend the drug release.
Carbamazepine was layered on sugar cores in fluidized bed coater using…
Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of…
In this excellent review article issued from the UNGAP program (European Network on Understanding Gastro-intestinal Absorption-related Process) you will find relevant and up-to-date information on:
- Poorly water soluble drugs and the link…