A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
The subdivision behavior of polymeric tablets
The subdivision behavior of polymeric tablets produced with the well-known polymers Soluplus® (SOL), polyvinyl pyrrolidone co-vinyl acetate (PVPVA) and hydroxypropyl methylcellulose (HPMC) was evaluated in this study.
The polymeric…
Pellet manufacturing technologies – an overview poster
Pellets and micropellets are an important part of the multiparticulates dosage forms. The manufacturing technologies to achieve pellets are versatile. The overview poster shows the different technologies from drug loading to matrix pellets…
Gattefossé – Going skin-deep safely with topical solubilizers
Understand the three formulation rules, ie solubility, partition, diffusion, for safe skin penetration enhancement with Gattefossé solubilizers.
See the full video here.
A rapid IPC test to monitor the functionality of taste masking polymer coatings using Broadband…
Monitoring of the coating end-point of functional coatings during the coating application process is desirable. Since currently available PAT methods require expensive test equipment, there is a need for a rapid test that can easily be…
Evaluating different manufacturing options to formulate loperamide HCl as orally disintegrating…
Orally disintegrating tablets (ODTs) have become a popular dosage form. Even though formulators have ready-to-use aids on hand, allowing quick and simple drug formulation, some formulations can raise the need for customised formulation…
Development and Applications of a Material Library for Pharmaceutical Continuous Manufacturing of…
The purpose of this study is to establish a material library and discuss its potential application to the development and lifecycle management of a continuous manufacturing process for solid dosage forms.
Particularly, this study…
Tablet coating goes continuous
Following the intro- duction of the continuous Glatt Modcos system, Glatt is working together with partner Driam to close a gap in the production process by incorporating continuous tablet coating. Like Modcos, the continuous Driaconti-T…
Innovation in microencapsulation
Learn more about Microcaps novel technology for the production of microparticles and microcapsules used to protect pharmaceutical agents in drugs or fragrances in cosmetic products. The technology enables high throughput and precise size…
Excipient-excipient interactions in the development of nanocarriers
Excipient interaction has become essential knowledge for rational formulation design of nanoparticles.
Nanostructured lipid carriers (NLCs) include at least three types of excipient, which enhance excipient
interaction possibilities and…
Synergistic Effect of Polyvinyl Alcohol and Copovidone in Itraconazole Amorphous Solid Dispersions
The first objective is to evaluate the feasibility of melt-extruding polyvinyl alcohol-based amorphous solid dispersions for oral drug delivery. The second objective is to investigate the miscibility between polyvinyl alcohol 4-88 and…
Huperzine a loaded multiparticulate disintegrating tablet
Huperzine A loaded multiparticulate tablet with sustained release was developed to reduce dosing frequency and increase swallowing.
The sustained release was provided by the ethyl cellulose/Poloxamer 127 (EC/F127) microparticles (MPs).…
Hot melt extrusion with PVA: A new opportunity for challenging APIs
On Thursday, August 22, 2019 Merck holds a webcaston the topic of
Hot melt extrusion with PVA: A new opportunity for challenging APIs
In this webcast, you will learn:
about amorphous solid dispersions and their…
Mucoadhesive hydrogels for buccal drug delivery
It was the aim of the study to assess in vitro methods for the characterization of mucoadhesive hydrogels for their potential to predict the residence time on human buccal mucosa.
Methods
Mixtures of hydrogels comprising hydroxyethyl…
Inkjet printing of solid oral dosage
Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate, followed by solidification. This process can potentially be used to address limitations for the manufacturing of solid…
Using zeta potential to study the ionisation behaviour of polymers employed in modified-release…
A range of enteric polymers is used in pharmaceutical industry for developing gastro-resistant formulations. It is generally implied that these coatings are interchangeable due to similar dissolution pH thresholds reported by suppliers.…
Solidifying ticagrelor loaded self-microemulsifying drug delivery system
The aim of this study was to solidify a ticagrelor loaded self-microemulsifying drug delivery system (TCG-SM) with enhanced dissolution and bioavailability of ticagrelor (TCG) for developing TCG-SM granules and tablets.
TCG was dissolved…
Towards Printed Pediatric Medicines in Hospital Pharmacies
To date, the lack of age-appropriate medicines for many indications results in dose manipulation of commercially available dosage forms, commonly resulting in inaccurate doses.
Various printing technologies have recently been explored in…
Screening of different polysaccharides in a composite film based on Eudragit RS for subsequent use…
This study aims at identifying the more suitable polysaccharide in a composite film based on Eudragit RS for 5-ASA delivery to the colon.
Different polysaccharides (pectin, chitosan, guar, inulin, and dextran) were examined. The…
Comprehensive study of co-processed excipients F- Melts®
This article aims to compare three commercially available co-processed excipients (CPEs), namely the F-Melts® type C, M and F1.
All three CPEs were subjected to the evaluation of their physical properties and afterwards compacts were…
Premium Ethylcellulose Polymer-Based Architectures at Work in Drug Delivery
Premium ethylcellulose polymers are hydrophobic cellulose ether based biomaterials widely employed as biocompatible templates for the design of novel drug delivery systems.
They are classified as United States Food and Drug…
Use of Microwave Resonance Technology to Determine Moisture Content in Batch Fluid Bed Processes
One of the most difficult Critical to Quality Attributes to measure in a fluid bed drying process is moisture content of the granulation.
Traditional methods require a fair amount of time to acquire a sample and test it offline. During…
Scale-Up of Hot-Melt-Extrusion
Hot-Melt-Extrusion on Twin-Screw-Extruders has been established as a standard processing technique for pharmaceutical products.
A major challenge is the transfer from a lab to a production level, since the combination of several unit…
Optimization of transdermal deferoxamine
Chronic wounds remain a significant burden to both the healthcare system and individual patients, indicating an urgent need for new interventions.
Deferoxamine (DFO), an iron-chelating agent clinically used to treat iron toxicity, has…
In-line monitoring of powder blend homogeneity in continuous drug manufacture using near infrared…
The pharmaceutical industry faces technical challenges in the near future when transitioning from the traditional batch wise manufacturing to continuous manufacturing.
One issue that needs to be solved is how to obtain high-quality…
Scaled-Up Production and Tableting of Grindable Electrospun Fibers
The aims of this work were to develop a processable, electrospun formulation of a model biopharmaceutical drug, β-galactosidase, and to demonstrate that higher production rates of biopharmaceutical-containing fibers can be achieved by using…
Pickering emulsions
An increased interest in Pickering emulsions has emerged over the last 15 years, mainly related to their very attractive properties compared to regular emulsions, namely their excellent stability and their numerous possible applications.…
WHO – Model List of Essential Medicines 2019
World Health Organization (WHO) has published the 2019 Model List of Essential Medicines.
The core list presents a list of minimum medicine needs for a basic health-care system, listing the most efficacious, safe and cost–effective…
Sprinkle Formulations—A Review of Commercially Available Products
Currently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug…
Gattefossé – Dual matrix
Discover the benefits of dual matrix, with Compritol® 888 ATO and HPMC, as sustained release agents to produce robust tablets.
See the full video here.
Dead mass in continuous blending
Continuous manufacturing is an emerging technology in secondary pharmaceutical manufacturing of oral solid dosage forms such as tablets.
Continuous blending is a crucial process step in continuous manufacturing. Residence mass (i.e. fill…
Implementation of real-time and in-line feedback control for a fluid bed granulation process
The application of process analytical technologies (PAT) to monitor critical quality attributes (CQAs) provides an important approach to enhance process understanding and improve the reliability of pharmaceutical production processes.…
New Drug Formulations and Their Respective Generic Entry Dates
BACKGROUND: After new prescription drugs reach the market, manufacturers
sometimes create modified versions of them. These new formulations
can expand patient treatment options, but they may also be protected by
later-expiring patents or…
EU and US reach a milestone in mutual recognition of inspections of medicines manufacturers
With the recognition by the US Food and Drug Administration (FDA) of Slovakia, the European Union and the United States have now fully implemented the mutual recognition agreement (MRA) for inspections of manufacturing sites for certain…
Fast dissolving oral films for drug delivery prepared from chitosan/pullulan electrospinning…
In this study, Chitosan/pullulan composite nanofiber fast dissolving oral films (FDOFs) were prepared via electrospinning technology.
The ratio of chitosan/pullulan (C/P) had an influence on solution property and nanofiber morphology,…