A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Intestinal absorption-modifying excipients
Pharmaceutical excipients in drug products are defined as pharmacologically inactive and are integral constituents of all types of oral dosage forms.
However, some excipients may increase drug absorption by interacting with the mucosal…
How to Measure Coating Thickness of Tablets: Method Comparison of Optical Coherence Tomography,…
Film coating of pharmaceutical dosage forms, such as tablets and pellets, can be used to tailor the drug release profile. With that regard, a uniform coating thickness of a single tablet (intra-tablet), all tablets (inter-tablet) and…
Noramco and SPI Pharma Announce Availability of New Excipient Compatibility Study for Cannabidiol…
WILMINGTON, Del., July 9, 2019 /PRNewswire/ -- Noramco and SPI Pharma announced that they have completed work on an excipient compatibility study examining a range of options for the development of cannabidiol (CBD) solid oral dosage forms,…
Implementation of real-time and in-line feedback control for a fluid bed granulation process
The application of process analytical technologies (PAT) to monitor critical quality attributes (CQAs) provides an important approach to enhance process understanding and improve the reliability of pharmaceutical production processes.…
The “UNIQUE” Single Punch Tablet Press
Ronchi Lab srl presents its UNIQUE single punch tablet press for galenical R&D laboratories, hospital and pharmacies and university laboratories. The UNIQUE is a small automatic single punch tablet press with an output of up to 4.000…
Enhancing sustained drug release property of chitosan
Chitosan has not been able to be formulated as sustained-release crosslinked/coacervated drug carrier in the form of spheroids prepared by extrusion-spheronisation technique.
This study re-visits chitosan spheroids and their drug…
Blend of cellulose ester and enteric polymers for delayed and enteric coating of core tablets of…
The focus of this work was to explore feasibility of using blends of cellulose esters (CA 320S, CA 3980-10 or CAB 171-15) and enteric polymers (C-A-P, Eudragit® L100 or HPMCP HP-55) for delayed and enteric coating of tablets containing…
Liqui-Pellet: the Emerging Next-Generation Oral Dosage Form Which Stems from Liquisolid Concept in…
In spite of the major advantages that the liquisolid technology offers, particularly in tackling poor bioavailability of poorly water-soluble drugs (i.e., BCS Class II drugs), there are a few critical drawbacks.
The inability of a high…
From batch to continuous — New opportunities for supercritical CO2 technology in pharmaceutical…
Poor solubility and bioavailability of new chemical entities is a major challenge that keeps plaguing the pharmaceutical industry and jeopardizes their away to the market.
Nanotechnologies hold a great promise to overcome these chemical…
β-Cyclodextrin as a Functional Excipient Used for Enhancing the Diminazene Aceturate Bioavailability
In this study, we proposed formulations of diminazene aceturate (DA) designed to improve its bioavailability and to maximize the therapeutic index in animals by overcoming the rapid degradation under the acidic pH of the stomach.
An…
Gattefossé – Straightforward SR matrix development
Learn how to develop Compritol® 888 ATO based sustained release tablets.
See the whole video here.
Direct powder extrusion 3D printing: Fabrication of drug products using a novel single-step process
Three-dimensional (3D) printing is revolutionising how we envision manufacturing in the pharmaceutical field. Here, we report for the first time the use of direct powder extrusion 3D printing: a novel single-step printing process for the…
Impacts of particle shapes on the oral delivery of drug nanocrystals: Mucus permeation,…
For drug nanocrystals (NCs), particle shapes can affect aqueous solubility, dissolution rate and oral bioavailability. However, the effects of particle shapes on the transport of NCs across the intestinal barriers remain unclear. In the…
Powder characterisation tools for powder processors
Following 20 years of experience in the field of powder characterisation, Freeman Technology has gained valuable insight into the product development and manufacturing issues that powder processors face on a daily basis. Alongside…
Decision Support for Excipient Risk Assessment in Pharmaceutical Manufacturing
Excipients have always been a key input into pharmaceutical products, profoundly affecting product quality. Currently, most of our knowledge of excipient critical quality attributes is empirical, gained through experience, and shared…
Free-flow for direct compression and enhanced adsorption capacity?
BIOGRUND’s one-step tabletting agent CompactCel® SIL provides an easy to use, granulated and homogeneous compound of Silica and PVP/NaCMC or HPC/NaCMC, which acts as a perfect dry binder granulate. With CompactCel® SIL it is possible to…
Fluidized bed granulation of two APIs: QbD approach and development of a NIR in-line monitoring…
The study focused on the fluid-bed granulation process of a product with two active pharmaceutical ingredients, intended for coated tablets preparation and further transfer to industrial scale. The work aimed to prove that an accurate…
Effect of operation conditions on coating of pharmaceutical pellets with a film of HPMC/PEG in a…
Wurster coater was utilized for coating glass beads with HPMC/PEG. The effects of design and operating parameters on the coating process were evaluated.
It was found that the pressure drop decreases when spraying the coating solution…
Characterization and evaluation of the performance of different calcium and magnesium salts as…
The performance of a series of inorganic salts as direct compression excipients was systematically evaluated.
The physical-chemical and technological properties of the different salts were investigated in terms of crystalline/amorphous…
Lipid Excipients for Cannabinoid Drug Products
The introduction of the cannabis plant into Western medicine dates to the 19th century when the plant was first used as an additive to patented medicines. The development of cannabis based therapies in the modern sense however came to a…
Gluten-free mannitol excipient for tableting from Roquette
A new wheat-free mannitol grade for direct compression is now available with similar direct compression tableting properties to complementary PEARLITOL® SD mannitol grades, enabling high productivity direct compression tableting, a key…
Chemoenzymatic surface modification of liposomal drug carriers
Thesis by Steffen Wöll - Christian-Albrechts-Universität Kiel
Drug encapsulation into a carrier system aims to refine drug characteristics via three major pathways. Firstly, physico-chemical properties may be improved. This includes…
Impacts of particle shapes on the oral delivery of drug nanocrystals
For drug nanocrystals (NCs), particle shapes can affect aqueous solubility, dissolution rate and oral bioavailability. However, the effects of particle shapes on the transport of NCs across the intestinal barriers remain unclear.
In the…
Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution…
In this study, we aimed to design a highly swellable and mechanically robust matrix tablet
(SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution
behavior of β-lapachone with low aqueous solubility.…
Delivery of Poorly Soluble Drugs via Mesoporous Silica: Impact of Drug Overloading on Release and…
The most important properties of promising drug candidates for oral dosage form are aqueous solubility and intestinal permeability. Over 40% of drugs on the market are BCS class II and IV, which have low solubility. Furthermore, new…
Novel Hot Melt Extruded Matrices of Hydroxypropyl Cellulose and Amorphous Felodipine–Plasticized…
Hydroxypropyl methylcellulose (HPMC) is a hydrophilic retarding-release polymer with the limited application in hot melt extrusion (HME) due to its high glass transition temperature (Tg181–191°C) and melt viscosity.
The aim of this study…
Stabilizing excipients for engineered clopidogrel
Clopidogrel bisulfate (CB) is a golden antiplatelet treatment, yet its benefits are limited by its low bioavailability (<50%) caused by poor intestinal solubility and absorption.
The present study aims to improve CB intestinal…
Gattefossé – Easy taste masking for paediatric medicines
Drug taste masking is easily obtained with Precirol® ATO 5 and a standard high shear mixer.
Discover the benefits of this simple and efficient process in the Gattefossé Tech Chat.
Solid Dose: Under-hyped but not under-represented
The buzz may be around biologics, but the oral solid dose sector is still going strong
By Karen Langhauser, Chief Content Director - Jun 13, 2019 - pharmamanufacturing.com
Tablets may not be as glamorous or cutting-edge as emerging…
70 years of Disease Research – Video
An interesting video by Helder Nakaya of how diseases were studied in the past 70 years. They have analyzed over 29,000,000 articles and 250GB of data. Computational Systems Biology Laboratory (csbiology.com). Source: PubMed…
β-Carotene solid dispersion prepared by hot-melt technology improves its solubility in water
β-Carotene is a member of the carotenoid family and is a red–orange pigment abundantly present in many vegetables and fruits.
As an antioxidant, it eliminates excessive reactive oxygen species generated in the body. Accordingly, it has…
Application of lactose in the pharmaceutical industry
This chapter describes the application of lactose as excipient in the pharmaceutical industry. About 60%–70% of pharmaceutical dosage forms contain lactose, and in volume it is one of the biggest pharmaceutical excipients.
Lactose can…
Pamidronate functionalized mucoadhesive compact for treatment of osteoporosis
The aim of the present study was to develop directly compressed compacts for mucoadhesive delivery of pamidronate disodium for the treatment of osteoporosis in the rat model induced by methylprednisolone.
A blend of HPMC-4KM and…
Quantification of Inkjet-Printed Pharmaceuticals on Porous Substrates Using Raman Spectroscopy and…
The use of inkjet printing for pharmaceutical manufacturing is gaining interest for production of personalized dosage forms tailored to specific patients. As part of the manufacturing, it is imperative to ensure that the correct dose is…