The benefits of lactose as an excipient
Used for over 100 years, pharmaceutical lactose is a milk sugar produced from cheese whey or milk permeate streams through a process of crystallisation, purification, milling and sieving. Today, it is well-established and commonplace in the pharmaceutical industry due to the numerous advantages of using lactose as an excipient.
Medicines are…
Integrated modeling of a continuous direct compression tablet manufacturing process: A production…
A flowsheet model for a continuous direct compression tableting process is developed and applied to process data generated at production scale.
The model contains powder feeding, blending and tablet compaction unit operations. The…
Ampholytic and Polyelectrolytic Starch as Matrices for Controlled Drug Delivery
The potential of the polyampholytic and polyelectrolytic starch compounds as excipients for drug controlled release was investigated using various tracers differing in terms of solubility and permeability.
Ampholytic…
Thermoplastic polyurethane as matrix forming excipient using direct and ultrasound-assisted…
Thermoplastic polyurethanes (TPU) are block copolymers utilized in a wide variety of applications due to their superior characteristics as resistance, flexibility and biocompatibility. However, the use of TPU as a matrix tablet forming…
Modelling of pharmaceutical formulations for continuous twin-screw wet granulation: Determination of…
Two-dimensional population balance model (PBM) is developed in order to model pharmaceutical granules formation in a twin-screw wet granulator. Granule size and liquid content are considered as internal coordinates, while axial length of…
Near infrared spectroscopy for rapid and in-line detection of particle size distribution variability…
Particle size distribution (PSD) variability in excipients may cause unacceptable prolongation of mixing time needed to achieve blend homogeneity. Therefore, it is vital to modulate mixing through real-time monitoring of PSD variability.…
Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application
The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where thermodynamics, polymer screening, multivariate statistics and…
Anionic and Cationic Vitamin E-TPGS Mixed Polymeric Phospholipid Micellar Vehicles
Berberine (Brb) is an active isoquinoline alkaloid occurring in various common plant species, with well-known potential for cancer therapy. Earlier reports has shown that Brb not only augments the efficacy of antineoplastic chemotherapy and…
In-vitro evaluation of solid lipid nanoparticles
Ability to encapsulate, release and ensure effective protection of peptides in the gastrointestinal tract
Peptides are rarely orally administrated due to rapid degradation in the gastrointestinal tract and low absorption at the…
New treatment for adrenal insufficiency in children
Professor Richard Ross from the University of Sheffield explains in this video the problematics of children suffering from adrenal insufficiency and the new treatment developed with the partners in the TAIN project. It is the first…
Lignin-based hydrogels
Lignin as the second most abundant and the only polyaromatics-contained bio-polymer in plant has been most studied for various applications. In the past decade, the utilization of lignin for value-added materials has been extensively sought…
Tablet tensile strength
Increasing tensile strength by reducing particle size for extrudate-based tablet formulations
The effect of milled extrudate particle size on tablet tensile strength was investigated in this study. Parameters used for milling with a hammer…
Porous hydroxyapatite pellets
Structure reinforcement of porous hydroxyapatite pellets using sodium carbonate as sintering aid: Microstructure, secondary phases and mechanical properties
Porous HAP pellets suitable for loading therapeutic agents were prepared using…
Calcium alginate beads
Calcium alginate beads loaded with Mg(OH)2 improve L. casei viability under simulated gastric condition
Alginate beads are commonly used for protection of probiotics against adverse environmental conditions. However, alginate beads are…
QbD for hot-melt extrusion
Holistic QbD approach for hot-melt extrusion process design space evaluation: Linking materials science, experimentation and process modeling
The aim of this work was to investigate the relationship between formulation material…
Top 200 Drugs 2018 – The Poster
Top 200 Brand Name Drugs by Retail Sales in 2018
Jon Njardarson from the University of Arizona has just published the poster with the Top 200 Brand Name Drugs by Retail Sales in 2018. It starts with Humira (Immunology) - USD 20.484…
Unlocking the full potential of lipid-based formulations using lipophilic salt/ionic liquid forms
Lipid-based formulations (LBF) are widely used by industry and accepted by the regulatory authorities for oral drug delivery in the pharmaceutical and consumer healthcare market. Innovation in the LBF field is however needed in order to…
3Dprinted PVA capsules
Design and 3D printing of multi-compartmental PVA capsules for drug delivery
3D printing is predicted to play a significant role in the future of the pharmaceutical industry. Personalized drug delivery, which includes personalizing…
Carvedilol loaded SMEDDS
Solidification of carvedilol loaded SMEDDS by swirling fluidized bed pellet coating
Self-(micro)emulsifying drug delivery systems (S(M)EDDS) have emerged as effective vehicles for enhancing bioavailability of poorly water soluble drugs,…
Particle Size-independent Variation of Bulk Excipients
Microcrystalline Cellulose (MCC) has been used as a pharmaceutical excipient for many years, due to its abundance, ease of production and resistance to degradation. As with any excipient, however, variability between batches of supplied…
Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and…
The physiological barriers of the eye pose challenges to the delivery of the array of therapeutics for the effective medication of ocular diseases as well as patient compliance. While the innovations in drug encapsulation and release…
Material Attributes and Their Impact on Wet Granulation Process Performance
1 Granulation Technology
Granulation technology is commonly used in the pharmaceutical industry during solid oral dosage form development, especially in tablet and capsule manufacturing (Parikh, 2010; Shanmugam, 2015). The process commonly…
Current Practices in Wet Granulation-Based Generic Product Development
Wet granulation is one of the most important unit operations in the production of pharmaceutical dosage forms. This chapter describes various wet granulation methodologies, with major focus on high-shear wet granulation (HSWG) and…
Critical Material Attributes in Wet Granulation
Quality by design (QbD) is a scientific and risk-based approach applicable throughout the product development process. The QbD principles are outlined in the ICH guidelines (Q8, Q9, and Q10) and are aimed at establishing a systematic…
Potential for pharmaceutical excipients to impact absorption
The potential for certain excipients to impact drug absorption is the subject of numerous publications. Reflecting this, current Biopharmaceutics Classification System (BCS) guidelines place restrictions on the level of change in excipients…
Numerical Modeling for Wet Granulation Processes
Granulation, defined as a size enlargement in which small particles stick together by having a liquid bind onto their surface, plays an extremely important role in the powder-handling process. It is widely applied in particle manufacturing…
A Quality By Design Approach to Scale-Up of High Shear Wet Granulation Process
High-shear wet granulation is a complex process that, in turn, makes scale-up a challenging task. Scale-up of high-shear wet granulation process has been studied extensively in the past with various different methodologies being proposed in…
3D printed lipid based formulations: a step forward!
In this study, the authors show that solid SMEDDS can be produced with a 3D printing process and solid and semi-solid lipid excipients. The proof of concept is established with cinnarizine and fenofibrate as model drugs.
PURPOSE: The use…
Implementation of Pharmaceutical Quality by Design in Wet Granulation
Granulation is a typical unit operation of particle enlargement carried out by the pharmaceutical industry to produce pharmaceutical dosage forms like tablets and capsules for over 70 years (Parikh, 2009). The purpose of wet …
Shedding Light on Coatings
Real-time Monitoring of Coating Quality at Industrial Scale
Optical Coherence Tomography (OCT) is increasingly being used for studies of pharmaceutical film coating. OCT allows fast and non-destructive analysis of the coating thickness…
The application of percolation threshold theory to predict compaction behaviour of pharmaceutical…
Percolation theory provides a statistical model which can be used to predict the behaviour of powder blends based on particle-particle interactions. The aim of this study was to investigate if percolation theory could be used to predict the…
Controlled release tablets based on HPMC:lactose blends
Hydroxypropyl methylcellulose (HPMC) is a frequently used matrix former for controlled release tablets. To adjust desired drug release kinetics, freely water-soluble lactose can be added.
The aim of this study was to investigate the…
Real-Time Monitoring of Particle Size Distribution in a Continuous Granulation and Drying Process by…
In continuous granulation, it can be important to control granules particle size distribution (PSD), as it may affect final product quality. Near infrared spectroscopy (NIRS) is already a routine analytical procedure within pharmaceutical…
Simplifed quality document sharing
Ingredientpharm just simplified the quality document sharing with their customers and Distributors using Qualit-e. Ingredientpharm is specialised in the development and marketing of added-value pharmaceutical excipients.
Qualit-e offers…
Tableting performance of various mannitol and lactose grades assessed by compaction simulation and…
Mannitol and lactose are commonly used fillers in pharmaceutical tablets, available in several commercial grades that are produced using different manufacturing processes. These grades significantly differ in particulate and powder…