Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Capsules Using Pelletization Technique
Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit…
Tableting performance of various mannitol and lactose grades assessed by compaction simulation and…
Mannitol and lactose are commonly used fillers in pharmaceutical tablets, available in several commercial grades that are produced using different manufacturing processes. These grades significantly differ in particulate and powder…
Shedding light on interaction of so called inactive ingredients (excipients) with…
Permeability glycoprotein (P-gp) is a 170 kDa membrane transporter from the category of efflux pumps, which is situated at the apical site of epithelial membrane. P-gp is known to efflux diverse classes of chemical compounds including…
Correlation between the solid state of lipid coating and release profile of API from hot melt coated…
Solvent-free hot melt coating (HMC) provides a safer and more economic process compared to the conventional solvent coating techniques. However, drug release instability and the lack of fundamental understanding on it are limiting factors…
A QCM-based assay of drug content in Eudragit RS 100-based delivery systems
A specific version of the quartz crystal microbalance method has been proposed for quantitative evaluation of drug content in polymeric drug carrier systems. In this study, ammonio methacrylate copolymer (type B) microparticles and their…
Effect of permeation enhancers on in vitro release and transdermal delivery of lamotrigine from…
The drug-in-adhesive (DIA)-type matrix patches of lamotrigine are developed using variable permeation enhancers (oleic acid, PG, lemon oil and aloe vera), and drug in vitro release and its permeation are evaluated.
Lamotrigine has been…
Electrospinning Optimization of Eudragit E PO with and without Chlorpheniramine Maleate Using a…
Electrospinning is increasingly becoming a viable means of producing drug delivery vehicles for oral delivery, particularly as issues of manufacturing scalability are being addressed. In this study, electrospinning is explored as a…
Sex-Dependence in the Effect of Pharmaceutical Excipients
Polyoxyethylated Solubilising Excipients Increase Oral Drug Bioavailability in Male but not Female Rats
It is known that males and females respond differently to medicines and that differences in drug behaviour are due to…
PERSONALIZED AND 3D-PRINTED: OUR FUTURE MEDICINES – Video
FabRx is a spin-out company from the University College London that focuses on 3D printing for pharmaceutical uses - and the first group to investigate Selective Laser Sintering (SLS) to make medicine. The Sintratec Kit has played a key…
Evaluation of an in-line NIR spectroscopic method for the determination of the residence time in a…
In the current study, the ability to use in-line NIR inside the feed frame of a tablet press to monitor the residence time distribution inside the tablet press was investigated.
Pulse-response experiments were performed. In-line…
Technical Due Diligence in the Pharmaceutical Industry
"Dectecting the (early) warning signs or optimizing when it is too late"
The examination and evaluation of pharmaceutical products and processes consists of a large number of evaluation steps which should always be performed by experts in…
Self-emulsifying Drug Delivery Systems and their Marketed Products: A Review
Self-emulsifying drug delivery systems (SEDDS) are one of the proven methods to increase solubility and bioavailability of poorly soluble drugs.
SEDDS are isotropic mixtures, consisting of oils, surfactants, and sometimes cosolvents.…
From lead to investigational new drug
The new e-Guide covers successful preclinical studies with Gattefossé excipients. Gattefossé developed a guideline to help formulate molecules with poor solubility and oral bioavailability into more drug-like compounds. The approaches…
Predicting the critical quality attributes of ibuprofen tablets via modelling of process parameters…
Roller compaction is a low cost granulation process which application is sometimes limited by the granular loss of compactability and reduced drug dissolution rate. Hence, the design of a robust manufacturing process is key in order to…
Speed up the moisture measurement of powders and granules – results in less than 15 seconds
This video nicely shows the difference of the conventional method of moisture measurement by halogen which requires about 15 minutes per measurement. The real-time moisture measurement done with TEWS microwave measurement is the new and…
Vitafoods Europe: Clean Label Alliance – Probiotics – CBD
Vitafoods 2019 brought together over 22.000 visitors from more than 110 countries with over 1.200 exhibitors to exchange 3 days on how to “Shape the food industry for optimal health through science and innovation”, solutions and science for…
Investigation of the parameters used in fused deposition modeling of poly(lactic acid) to optimize…
This study assesses the feasibility of printing implantable devices using 3D printing Fused deposition modeling (FDM) technology.
The influence of the deposition temperature, the deposition rate and the layer thickness on the printing…
Development of biologics: The market requires short development times and high productivity
Biologics offer new therapy options for numerous diseases: They are already used to treat cancer and autoimmune diseases such as rheumatoid arthritis as useful alternatives to standard therapies. The extent of their market potential is…
Printing of small molecular medicines from the vapor phase
There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor…
Long-term storage of PEGylated liposomal oxaliplatin
Liposomal anticancer drugs have been developed with improved clinical effects and reduced side effects. We have developed a PEGylated liposomal formulation of oxaliplatin that has anticancer effects in animal models of colorectal cancer…
Drug delivery through wafer technology: Formulation and manufacturing of buccal and oral…
A great number of patients have difficulty swallowing or needle fear. Therefore, buccal and orodispersible dosage forms (ODFs) represent an important strategy to enhance patient compliance. Besides not requiring water intake, swallowing or…
3D Printing of Pharmaceutical and Medical Applications: a New Era
Three – dimensional (3D) printing has revolutionised the field of pharmaceutical dosage forms. 3D printing is a process used to fabricate three dimensional objects based on the layer – by - layer deposition of materials on a computer…
Mini-tablets as an alternative galenic formulation for neonates
In the field of paediatrics the lack of evidence-based knowledge about treatment options for children is still remarkably high, which may result in administration of inaccurate dosages and inappropriate formulations of drugs in young…
Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive…
Purpose
Dissolution speeds of tablets printed via Fused Deposition Modeling (FDM) so far are significantly lower compared to powder or granule pressed immediate release tablets. The aim of this work was to print an actual immediate…
Excipient Interactions in Glucagon Dry Powder Inhaler Formulation for Pulmonary Delivery
This study describes the development and characterization of glucagon dry powder inhaler (DPI) formulation for pulmonary delivery. Lactose monohydrate, as a carrier, and L-leucine and magnesium stearate (MgSt) were used as dispersibility…
Development of a Simple Mechanical Screening Method for Predicting the Feedability of a…
Purpose
The filament-based feeding mechanism employed by the majority of fused deposition modelling (FDM) 3D printers dictates that the materials must have very specific mechanical characteristics. Without a suitable mechanical profile,…
Rapid Preparation of Spherical Granules via the Melt Centrifugal Atomization Technique
Granules with superior fluidity and low moisture absorption are ideal for tableting and capsule filling. Melt granulation as a solvent-free technology has attracted increasing interest for the granulation of moisture-sensitive drugs.
The…
Three-Dimensional Printing of Cell Exclusion Spacers (CES) for Use in Motility Assays
Migration and invasion (migration/invasion) assays are common methods used to study cell motility, development, inflammation, wound healing and invasion of malignant cells in cancer.
In migration/invasion assays, several approaches…
Biodegradable polymers for modern vaccine development
Most traditional vaccines are composed either of a whole pathogen or its parts; these vaccines, however, are not always effective and can even be harmful. As such, additional agents known as adjuvants are necessary to increase vaccine…
3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. The 3D printing has become one of the most revolutionary and powerful tool serving as a technology…
An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for…
Purpose
Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has…
Development of a novel method utilising dissolution imaging for the measurement of swelling…
A variety of imaging techniques are currently used within the field of pharmaceutics to help understand and determine a wide range of phenomena associated with drug release from hydrophilic matrix tablets.
This work for the first time…
Engineering Size and Structure of Particles in Novel Modified-Release Delivery Systems
Particle engineering has become a hot topic in the field of modified-release delivery systems during last decades. It has a wide range of pharmaceutical applications and is a bridge linking between drugs and drug delivery systems.…
Enrollment completed of Phase 1 Clinical Trial of Captisol-enabled Iohexol
SAN DIEGO--(BUSINESS WIRE)-- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announces completion of enrollment of the Company’s Phase 1 clinical trial of its internal Captisol-enabled (CE) Iohexol program. The CE-Iohexol program is…
Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a…
As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively poor water solubility and permeation in vivo. In the study, we developed novel solid dispersions (SD) of LPV to improve its bioavailability and to…