Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Enrollment completed of Phase 1 Clinical Trial of Captisol-enabled Iohexol
SAN DIEGO--(BUSINESS WIRE)-- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announces completion of enrollment of the Company’s Phase 1 clinical trial of its internal Captisol-enabled (CE) Iohexol program. The CE-Iohexol program is…
Solubility and bioavailability enhancement study of lopinavir solid dispersion matrixed with a…
As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively poor water solubility and permeation in vivo. In the study, we developed novel solid dispersions (SD) of LPV to improve its bioavailability and to…
“From Powders to Agglomerates” an Overview on Process Technologies and characteristics of the…
Download the Poster or order a Hard Copy (Format Din A0) here
The poster "From Powders to Agglomerates" gives an overview on the different process technologies and processing steps involved for each technology. It also shows the…
Multicomponent solid dispersion as a formulation strategy to improve drug permeation
Multicomponent solid dispersions (MSD)s are frequently proposed as efficient drug delivery systems to improve drug solubility and bioavailability. In this study, the effects of specific excipients, such as mannitol, inulin, poly(methyl…
Drug delivery innovation: Vitamin E TPGS and Polyamino acids
Vitamin E TPGS, a water soluble derivative of natural Vitamin E, is a multirole excipient for pharmaceutical drug delivery innovation. Vitamin E TPGS is a non-ionic surfactant used as:
solubilizer of poorly soluble drugs…
Preparation of cocrystal-in-excipient systems by advanced pharmaceutical methods
This thesis has focused on the study of pharmaceutical cocrystal production, and the impact of introducing an excipient into the manufacturing process. Cocrystals of sulfadimidine (SDM) and 4-aminosalicylic acid (4ASA) were formed in the…
Oral delivery of nanoparticles – let’s not forget about the protein corona
The learnt lesson: protein corona governs the fate of nanoparticles in the systemic circulation
The idea of using nanotechnology as drug delivery tool has been around for decades, with the exciting – yet perhaps simplistic – perspective…
Dense CO2 technology: Overview of recent applications for drug processing/formulation/delivery
Dense carbon dioxide technology is promising for the processing of drug compounds and development of varied pharmaceutical formulations through micronization, coprecipitation, encapsulation and coating techniques. The main advantages of…
Electrospun Nanofibers for Tissue Engineering with Drug Loading and Release
Electrospinning technologies have been applied in the field of tissue engineering as materials, with nanoscale-structures and high porosity, can be easily prepared via this method to bio-mimic the natural extracellular matrix (ECM). Tissue…
Measure coating thickness and characteristics in less than 2 minutes
With the OSeeT technology from Phyllon the measurement of tablet coating quality including
Coating thickness
Coating homogeneity
Surface roughness
can easily be measure at-line as shown in the Video below. The system works as…
China based innovation, CDMOs and Parallel Approvals driving huge growth in manufacturing at CPhI…
Significant increase in exhibitors driven by bio growth at bioLIVE and separate nutraceuticals event.
Shanghai, April 2019: CPhI & P-MEC China(#CPhIChina and #PMECChina) – co-organized by UBM EMEA, CCCMHPIE, and UBM Sinoexpo – takes…
Neutral & functional starter pellets at Vitafoods
Ingredientpharm provides innovative drug carriers by changing the physical properties of existing excipients.We offer our expertise and technology to enhance the performance of APIs - mainly in the field of taste masking but also for easier…
Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical…
Injectable thermo-responsive hydrogels have been studied for various biomedical applications including; drug delivery, cell encapsulation, and tissue repairing. There are various natural and synthetic polymers which exhibit homogenous…
Processability of AquaSolve™ LG polymer by hot-melt extrusion
The objective of this study was to investigate the processability of AquaSolve™ hydroxypropyl methylcellulose acetate succinate L grade (HPMCAS LG) via hot-melt extrusion and to examine the effect of pressurized carbon dioxide (P-CO2) on…
Solid lipid particle-based tablets for buccal delivery
This study aims to develop mucoadhesive tablets containing solid lipid particles for controlled release pattern through buccal delivery. The buccal tablets containing drug-loaded solid lipid particles (SLPs) were fabricated using the…
A novel bitter masking approach: Powder coating technology-take Sanhuang tablets as an example
Sanhuang tablets (SHT) had a broad antibiotic spectrum with high efficiency and low toxicity. However, the clinical application was seriously limited by extremely bitter taste.
A novel powder coating technology was established to mask…
France to ban titanium dioxide in food from 2020 – what happens in Pharma?
France will ban Titanium dioxide as an additive in food in France from January 1, 2020, the Ministries of Ecology and Economy have said. The government has decided to ban "as a precaution" foodstuffs containing titanium dioxide (TiO2, an…
Formulation evaluation of ketoconazole microemulsion‐loaded hydrogel with nigella oil as a…
Onychomycosis is an opportunistic fungal infection often infecting people with compromised immune system. Currently available treatment interventions such as physical, surgical, and chemical‐based approaches are successful in treating the…
Adjustment of triple shellac coating for precise release of bioactive substances with different…
Formulations for the controlled release of substances in the human terminal ileum and colon are essential to target the gut microbiome and its interactions with the intestinal mucosa. In contrast to pharmaceutical enteric coatings, reliable…
Preparation and Evaluation of Topically Applied Azithromycin Based on Sodium Hyaluronate in…
Azithromycin (AZI) eye drops containing sodium hyaluronate (SH) were developed to improve the bioavailability of AZI. Interaction between AZI and SH in the AZI-SH formulation was investigated by differential scanning calorimetry, X-ray…
Inhalable co-amorphous budesonide-arginine dry powders prepared by spray drying
Spray drying is a well-established technology to produce inhalable dry powders. However, the amorphous nature of the particles typically obtained from the process can lead to physically and chemically unstable products.
The purpose of…
Top drugs and pharmaceutical companies of 2018 by revenues
The drug pricing debate continued to dominate news headlines in 2018, and many companies were in the news for lowering drug prices to make treatments more affordable.
Despite that, most major pharmaceutical companies saw their sales grow…
Characterization of Amorphous Solid Dispersion of Pharmaceutical Compound with pH-Dependent…
A continuous-spray granulator (CTS-SGR) is a one-step granulation technology capable of using solutions or suspensions.
The present research objectives were, (1) to reduce the manufacturing operations for solid dosage formulations, (2)…
Smart Mesoporous Silica Nanoparticles for Protein Delivery
Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great…
Two-component cross-linkable gels for fabrication of solid oral dosage forms
Current three-dimensional (3D) printing techniques involve the solidification of the injected materials by means of UV irradiation, evaporation of organic solvents, or harsh heating and cooling processes. These methods limit the printing of…
Formulation of Pioglitazone-Eudragit® RS100 Nanobeads and Nanofibers Using Electrospraying Technique
In the present study, a novel polymeric nanoparticle-based drug delivery system was developed to enhance the dissolution rate of poorly water-soluble drug pioglitazone hydrochloride (PGH) using hydrophilic Eudragit® RS100 (Eudr) as a…
Liquisolid pellets: A pharmaceutical technology strategy to improve the dissolution rate of…
Liquisolid pellets (LPs) prepared by extrusion-spheronization are promising delivery systems to improve the dissolution rate of poorly water-soluble drugs. However, developing LPs for high dose drugs (e.g. antiretroviral ritonavir, RTV) is…
Data reconciliation in the Quality-by-Design (QbD) implementation of pharmaceutical continuous…
Data provided by in situ sensors is always affected by some level of impreciseness as well as uncertainty in the measurements due to process operation disturbance or material property variance.
In-process data precision and reliability…
Evaluation of Hydrogenated Soybean Phosphatidylcholine Matrices Prepared by Hot Melt Extrusion for…
The aims of this study were to prepare hydrogenated soybean phosphatidylcholine (HSPC) matrices by hot melt extrusion and to evaluate resulting matrix potential to extend drug release in regard to drug loading and solubility for oral drug…
Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug…
Oral administration is the most common route of drug delivery. The absorption of a drug from the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of the active pharmaceutical ingredient and its…
Characterisation of mini-tablets – Pediatrics
Mini-tablets are a pharmaceutical dosage form with a diameter of typically ≤ 3 mm. This is a potential dosage form for pediatrics since the small size of mini-tablets can ease the swallowing of medicines. In recent years there has been an…
3D Printed Oral Theophylline Doses with Innovative ‘Radiator-Like’ Design
Despite the abundant use of polyethylene oxides (PEOs) and their integration as an excipient in numerous pharmaceutical products, there have been no previous reports of applying this important thermoplastic polymer species alone to fused…
Statistical optimization of alginate-based oral dosage form of 5-aminosalicylic acid aimed to…
Although different colon-targeting methods such as pH and time-dependent as well as bacterially degradable systems have been developed, due to variations in physiological conditions of patients, one system alone cannot produce a reliable…
High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients…
Excipients are critical components of a biotherapeutic product as they have a direct impact on the product's stability and hence on its safety and efficacy. A typical biotherapeutic drug product has a variety of excipients and these need to…