Deciphering the Role of Plasticizers and Solvent Systems in Hydrophobic polymer coating on Hydrophilic core
Abstract
The type of plasticizer and the choice of solvent or co-solvents used for coating of a hydrophilic core can greatly impact the permeability, porosity, and mechanical strength of the polymer film. Although, Ethylcellulose (EC) is an old polymer, it is a polymer of choice for modifying the drug release due to its inherent properties. The…
High performance liquid chromatography (HPLC) based direct and simultaneous estimation of excipients…
Excipients are critical components of a biotherapeutic product as they have a direct impact on the product's stability and hence on its safety and efficacy. A typical biotherapeutic drug product has a variety of excipients and these need to…
Water-Based 3D Inkjet Printing of an Oral Pharmaceutical Dosage Form
Inkjet printing is a form of additive manufacturing where liquid droplets are selectively deposited onto a substrate followed by solidification. The process provides significant potential advantages for producing solid oral dosage forms or…
Screening of Sacrificial Excipients for Arresting Devitrification of Itraconazole from Solid…
The aim of the present investigation was to develop a solid dispersion of itraconazole (ITR) using sacrificial excipients like pregelatinized starch and spray-dried lactose alongside hydroxypropyl methylcellulose and Poloxamer 188, thereby…
3D printing and characterization of hydroxypropyl methylcellulose and methylcellulose for…
The currently available support materials used with 3D printing technology have challenges of poor dissolvability in chemical solution and difficulty to be removed from the finished part. Current support materials are usually petroleum…
Development and Palatability Assessment of Norvir® (Ritonavir) 100 mg Powder for Pediatric…
Norvir® (ritonavir) is a Biopharmaceutical Classification System Class IV compound with poor solubility in water (~5 μg/mL) and limited oral bioavailability. Early stage development efforts were focused on an oral solution (OS) which…
Design and evaluation of novel inhalable sildenafil citrate spray-dried microparticles for pulmonary…
Pulmonary delivery of vasodilators is a promising alternative for the intravenous and oral treatment of pulmonary arterial hypertension (PAH). The aim of this study was to design and evaluate hydrogel microparticles as a carrier for…
Additive Manufacturing of Personalized Orodispersible Warfarin Films
Warfarin is a narrow therapeutic index drug that requires personalized dosing which is currently not achieved by the marketed products. Further, pediatric and geriatric patients may face swallowing problems with solid oral dosage forms. To…
Achieving High Excipient Efficiency with Elastic Thermoplastic Polyurethane by Ultrasound Assisted…
Ultrasound assisted compression (USAC) is a manufacturing technique which applies thermal and mechanical energy to the powder bed, producing tablets with improved characteristics compared to the direct compression process. This technology…
Chitosan/poly(2-ethyl-2-oxazoline) films for ocular drug delivery: formulation, miscibility, in…
Polymeric films were prepared based on chitosan and its blends with poly(2-ethyl-2-oxazoline) by casting from aqueous solutions. These materials were characterised using a number of physicochemical techniques, including Fourier-transform…
Tuning the Transdermal Delivery of Hydroquinone upon Formulation with Novel Permeation Enhancers
Hydroquinone (HQ) is an anti-hyperpigmentation agent with poor physicochemical stability. HQ formulations are currently elaborated by compounding in local pharmacies. Variability in the characteristics of HQ topical formulations can lead to…
Modelling the Effect of Process Parameters on the Wet Extrusion and Spheronisation of High-Loaded…
The aim of the present study was to develop an alternative process to spray granulation in order to prepare high loaded spherical nicotinamide (NAM) pellets by wet extrusion and spheronisation. Therefore, a quality by design approach was…
Formulation and optimization of lyophilized nanosuspension tablets to improve the physicochemical…
Silymarin (SLM) is a hepatoprotective herbal drug characterized by low aqueous solubility and, consequently, low oral bioavailability. The objective of this study was to enhance the physiochemical properties of SLM, through preparation and…
Amorphous pullulan trehalose microparticle platform for respiratory delivery
Spray drying biologics and small-molecule drugs can increase their thermal stability relative to liquid dosage forms and allow for widespread distribution to developing countries without cold chain infrastructure. In this study, pullulan…
Clay nanotubes as a novel multifunctional excipient for the development of directly compressible…
Halloysite is a unique biocompatible aluminosilicate clay mineral with powder particles predominantly comprising of concentrically rolled nanotubular aggregates. Some recent studies have also contributed to its prospective case in oral drug…
Ultra–fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive
Orodispersible tablets (ODTs) are a convenient dosage form and a recent trend in formulation development. The fast disintegration is accompanied by rapid removal of the active principle and the excipients from the mouth due to saliva flow…
A pharmaceutical answer to nonadherence: Once weekly oral memantine for Alzheimer’s disease
Adherence to medication regimens is a major barrier to effective treatment in many disease areas, notably in dementia which causes cognitive impairment that reduces patients' awareness of non-adherence and their ability to manage…
Adhesive alginate for buccal delivery in aphthous stomatitis
Recurrent aphthous stomatitis being the most common chronic disease of the oral cavity affects 5–25% of the population.
Aim
This study goals to develop a novel polymeric excipient based on alginate with enhanced mucoadhesion and…
Enhancing dissolution of artesunate from immediate release tablets using a green granulation…
Artesunate is a poorly soluble drug and liable to aqueous hydrolysis. This study aims to formulate Artesunate as an immediate release tablet through optimization of the melt granulation technique to improve the dissolution of the drug.…
DNA scaffold nanoparticles coated with HPMC/EC for oral delivery
The control of the glycemic level among diabetes/T2 patients is very important for their long term survival and avoiding further complexities including micro/macrovascular diseases as well as diabetic neuropathy. Vildagliptin (VD) is a drug…
Drug-carrier binding and enzymatic carrier digestion in amorphous solid dispersions containing…
In order to further explain the ability of gelatin 50PS and bovine serum albumin (BSA) to generate supersaturation of a series of poorly soluble drugs (carbamazepine, cinnarizine, diazepam, itraconazole, nifedipine, indomethacin, darunavir…
Acoustic levitation as a screening method for excipient selection in the development of dry powder…
Spray drying is emerging as a promising technique to produce thermally stable powder vaccines containing viral vectors. One of the most important factors in developing dry powder vaccines is the selection of the excipient carrier, however…
Particle Engineering of Excipients
In this work, lignin was spray dried with sodium lauryl sulphate (SLS) in order to improve the compaction properties of lignin. Bulk level and physicochemical properties of spray dried formulations were measured and compared to as-received…
Electrospun nanofibers for customized drug-delivery systems
Nanofiber-based drug-delivery systems are widely applicable for specific drug release, according to the target location and timing, to achieve the desired therapeutic effects. A nanofiber formulation is usually developed for a specific…
Characterization and evaluation of different mesoporous silica kinds as carriers for the development…
This work evaluated the suitability of various mesoporous silicas as carriers for developing an oral formulation endowed with improved dissolution properties of glibenclamide, hypoglycemic agent poorly water-soluble.
The different…
3D printed chitosan dressing crosslinked with genipin for potential healing of chronic wounds
Recently, various additive manufacturing (3D printing) approaches have been employed to fabricate dressings such as film scaffolds that possess well-defined architecture and orientation at the micro level. In this study, crosslinked…
Evaluation of a Methylcellulose and Hyaluronic Acid Hydrogel as a Vehicle for Rectal Delivery of…
Biologics have changed the management of Inflammatory Bowel Disease (IBD), but there are concerns regarding unexpected systemic toxicity and loss of therapeutic response following administration by injection. Local delivery of biologics…
Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
Quercus Suber Bark from Quercus suber L. is a natural, renewable and biodegradable biomaterial with multifunctional proprieties. In this study, we used it as solid particles to stabilize a Pickering emulsion. The main goal was to produce an…
Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects. Each delivery method has favorable aspects and…
Effect of starch and hydroxypropyl methylcellulose polymers on the properties of orally…
Considering the advantages of orally disintegrating films as alternative pharmaceutical dosage forms, the objective of this work was to develop and evaluate different formulations of orally disintegrating films based on pre-gelatinised…
Scale-up of Pharmaceutical Spray Drying Using Scale-up Rules
Spray drying is one of the widely used manufacturing processes in pharmaceutical industry. While there are voluminous experimental studies pertaining to the impact of various process–formulation parameters on the quality attributes of spray…
Quality-by-Design based development and characterization of pioglitazone loaded liquisolid compact…
The present research work describes the formulation development of liquisolid compact tablets of pioglitazone for improving its dissolution performance and antidiabetic activity. Using Quality by Design (QbD) approach, a total of nine…
Developing methodology to evaluate the oral sensory features of pharmaceutical tablet coatings
Acceptability of medicines is critical for effective pharmacotherapy. The aim of this study was to investigate the oral sensory properties of tablet coatings to determine how mouthfeel can improve acceptability. A randomised double-blind…
Polymer degradation induced drug precipitation in PLGA implants – Why less is sometimes more
Nifedipine and nicardipine loaded PLGA extrudates have a great potential to prevent cerebral vasospasms after subarachnoid hemorrhage or surgical clipping of aneurysm. A constant release over approx. two weeks is desired. Although in vivo…
Lyophilized liposome-based parenteral drug development
Given the successful entry of several liposomal drug products into market, and some with decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to overcome certain limitations of traditional drug delivery,…