Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Interested in Granulation Technology? Get the free overview poster
Glatt Pharmaceutical Services has put together an explanatory poster covering the different technologies for agglomeration / granulation based on powders, melts and liquids. Interested to get the full poster? Send us an email or visit our…
Effects of Drugs and Excipients on Hydration Status
Despite being the most essential nutrient, water is commonly forgotten in the fields of pharmacy and nutrition. Hydration status is determined by water balance (the difference between water input and output). Hypohydration or negative water…
Chitosan Coating Applications in Probiotic Microencapsulation
Nowadays, probiotic bacteria are extensively used as health-related components in novel foods with the aim of added-value for the food industry. Ingested probiotic bacteria must resist gastrointestinal exposure, the food matrix, and storage…
Have a look at the DDF Summit 2019 presentation of GRACE Mesoporous Silica DDS
At this year's 10th DDF Summit in Berlin, Fred Monsuur from GRACE held a presentation on Mesoporous Silica DDS - An Option for Liquisolid Drug Delivery Systems.
Did you miss the event and or want to have a look at the slides again? We…
“Inactive” ingredients may not be, study finds – relevant for allergies?
Most pills and capsules, whether over-the-counter or prescription, include components other than the actual drug. These compounds, known as “inactive ingredients,” help to stabilize the drug or aid in its absorption, and they can make up…
Oral Delivery of Puerarin Nanocrystals To Improve Brain Accumulation and Anti-Parkinsonian Efficacy
Puerarin (PU) has emerged as a promising herb-derived anti-Parkinsonism compound. However, the undesirable water solubility as well as the unwanted bioavailability of PU limit its application. Therefore, this study aimed to develop and…
Acrylated Eudragit® E PO as a novel polymeric excipient with enhanced mucoadhesive properties for…
Eudragit® E PO (EPO) is a terpolymer based on N,N-dimethylaminoethyl methacrylate with methylmethacrylate and butylmethacrylate, produced by Evonik Industries AG as a pharmaceutical excipient. In this work, EPO was chemically modified…
Providing Clean Label Solutions for Vitamins & Supplements
In the global dietary supplement market, consumer demands for cleaner labels continues to drive the development of new and innovative products. Additionally, regulatory agencies are also increasingly active in ensuring the safety of food…
Chemometric study of the excipients’ influence on polymorphic-behavior
The assessment of polymorphism is a problematical issue for regulatory agencies, because variations among crystalline forms of active pharmaceutical ingredient (API) can lead to changes in the efficacy and safety of formulated product. Such…
Comparison between integrated continuous direct compression line and batch processing – The effect…
There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was to test the ability of an integrated continuous direct compression (CDC) line,…
Calculation of drug-polymer mixing enthalpy as a new screening method of precipitation inhibitors…
Supersaturating formulations are widely used to improve the oral bioavailability of poorly soluble drugs. However, supersaturated solutions are thermodynamically unstable and such formulations often must include a precipitation inhibitor…
Development of a dosing device for individualized dosing of orodispersible warfarin films
Individualized medicine is relevant to ensure safe and efficient pharmacotherapy. It requires a suitable dosage form and a matching dosing device to enable flexible dosing serving the needs of individual dose requirements. For oral films no…
How to assess oral dispersible film quality?
In recent years, there has been a tendency toward creating innovative, easy to use and patient-friendly drug delivery systems suitable for every consumer profile, which would ensure safety, stability and acceptability of a drug. One of the…
Nanoparticulate Drug Delivery Systems for Pseudomonas aeruginosa Infected Lungs in Cystic Fibrosis
Current pulmonary treatments against Pseudomonas aeruginosa infections in cystic fibrosis (CF) lung suffer from deactivation and immobilization of the drug in thick and viscous biofilm/mucus blend, along with the general antibiotic…
Herringbone-Patterned 3D-Printed Devices as Alternatives to Microfluidics for Reproducible…
Major barriers to the implementation of nanotechnology include reproducible synthesis and scalability. Batch solution phase methods do not appear to have the potential to overcome these barriers. Microfluidic methods have been investigated…
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules.…
Corona alternating current electrospinning: A combined approach for increasing the productivity of…
Corona alternating current electrospinning (C-ACES), a scaled-up productivity electrospinning method was developed by combining the intense forces of the alternating electrostatic field and a sharp-edged spinneret design with increased free…
PMC Isochem consolidates its strategy of growth in Drug Delivery with a flagship Trademark
See the newest press release of PMC Isochem:
The GMP Drug Delivery offer of PMC Isochem
PMC Isochem has been producing GMP Vitamin E TPGS for 10 years, more than 5 years before European regulation requested GMP standard for excipients.…
Drug nanocrystals: fabrication methods and promising therapeutic applications
The drug nanocrystals (NCs) with unique physicochemical properties are now considerd as a promising drug delivery system for poorly water-soluble drugs. So far > 20 formulations of NCs have been approved in the market. In this review, we…
Pharma Excipients Poster Award 2018: Check the winners
We are very excited to announce the winners of the 2018 Pharma Excipients Poster Award!
With this poster award we wanted to increase the visibility of all the work put into preparation of pharmaceutical and excipient posters for the…
Crystallisation in printed droplets: understanding crystallisation of D-mannitol polymorphs
Crystallisation of mannitol in the confinement of inkjet printed droplets was studied; the effects of droplet size and the presence of a foreign surface were investigated in comparison to the commonly used manufacturing technique of spray…
Excipient selection for thermally stable enveloped and non-enveloped viral vaccine platforms in dry…
Two enveloped viral vectors, vesicular stomatitis virus and influenza virus, and a non-enveloped viral vector, human adenovirus type 5, were encapsulated by spray drying to enhance thermal stability. Results with these candidates led to the…
Multi-dimensional visualization for the morphology of lubricant stearic acid particles and their…
The shapes of particles and their distribution in tablets, controlled by pretreatment and tableting process, determine the pharmaceutical performance of excipient like lubricant. This study aims to provide deeper insights to the…
Potential Use of Magnesium Oxide as an Excipient to Maintain the Hardness of ODTs
This study aimed to clarify the effects of magnesium oxide (MgO) on the hardness of orally disintegrating tablets (ODTs) during storage. ODTs containing a range of MgO concentrations were prepared by direct powder compression and stored for…
Quality Considerations for Continuous Manufacturing
Guidance for Industry - DRAFT GUIDANCE - pdf download at the end of the text.
This guidance document is being distributed for comment purposes only.
Comments and suggestions regarding this draft document should be submitted within 90…
Review on plant derived excipients
Plants act as a major source of medicines and are used to formulate various pharmaceutical preparations. Apart from this, they act as excellent pharmaceutical aids as well as excipients.
Objective:
An effort has been made for the…
The effects of the treatment conditions on the dissolution profile of ethylcellulose coated pellets
Due to the additional particle coalescence in the coating, changes in the dissolution profile occur over time in the formulations coated by aqueous ethylcellulose latex. Dry thermal treatment (DT) of the coating can be used as a prevention…
Dissolution testing of oral films
In vitro dissolution testing is one of the most frequently used tests in pharmaceutical quality control, since evaluation of the drug release profile and estimation of the dosage form performance is enabled. However, for oral film…
Capsugel® Colorista™ capsule – an introduction video by Nicolas Madit
Capsugel® Colorista™ R&D technology was developed after hearing customer stories about color challenges related to timelines, fill, capsule compatibility and compliance. Colorista™ is a new tool that has large implications for gaining…
Evonik agrees to sell its Methacrylates business to Advent International for €3 billion
Essen, Germany. Evonik has today signed an agreement to sell its Methacrylates business to Advent International for €3 billion. The selling price (enterprise value) is 8.5 times the business’ EBITDA. The transaction is subject to approval…
Influence of material properties and equipment configuration on loss-in-weight feeder performance…
A programme of work on continuous tablet manufacturing was completed as part of a UK based collaborative research project (REMEDIES: RE-configuring MEDIcines End-to-end Supply) to evaluate the operating space of the continuous platform with…
tesa Labtec, CDMO for transdermal patches and oral films, now in US
The German based contract developer and contract manufacturer for transdermal patches and oral films moves closer to its customers and partners in the United States and Canada. Dr. Ahmad Ghoniem, Manager Business Development & Sales…
Taste Masking Challenge of Solubility Enhancing Excipients – A Case Study
The major part (approx. 80%) of new drug actives are poorly soluble. Several techniques are used to enhance solubility including but lot limited to alternative salt forms, particle size reduction and solubility-enhancing excipients.…
Formation of drug-rich amorphous nanodroplets
Drug-rich amorphous nanodroplets have great potential to improve intestinal absorption of poorly water-soluble drugs. Spray-dried samples (SPDs) of glibenclamide (GLB) with hypromellose (HPMC) or hypromellose acetate succinate (HPMC-AS,…