Deciphering the Role of Plasticizers and Solvent Systems in Hydrophobic polymer coating on Hydrophilic core
Abstract
The type of plasticizer and the choice of solvent or co-solvents used for coating of a hydrophilic core can greatly impact the permeability, porosity, and mechanical strength of the polymer film. Although, Ethylcellulose (EC) is an old polymer, it is a polymer of choice for modifying the drug release due to its inherent properties. The…
Formation of drug-rich amorphous nanodroplets
Drug-rich amorphous nanodroplets have great potential to improve intestinal absorption of poorly water-soluble drugs. Spray-dried samples (SPDs) of glibenclamide (GLB) with hypromellose (HPMC) or hypromellose acetate succinate (HPMC-AS,…
The Use of 3D Printed Molds to Cast Tablets with a Designed Disintegration Profile
Development of new product design principles is crucial for obtaining pharmaceutical products with controlled functionality. Four different molds were designed using a computer-aided design (CAD) software and 3D printed with polylactic acid…
Poly(vinyl alcohol) 3D printed tablets: The effect of polymer particle size on drug loading and…
Fused deposition modeling by 3D-printing is a rapid technique for the production of personalized drug dosage forms. One of the most delicate step of the whole process is the drug loading onto the thermoplastic polymer to obtain the…
Formulation and evaluation of gastric-floating controlled release tablets of Ginkgolides
The present investigation was conducted to formulate and evaluate gastric-floating controlled release tablets of Ginkgolides. The target tablets were formulated by powder direct compression method combined with hydrophilic polymer, floating…
High-throughput screening of excipients with a biological effect
In this study, we develop and apply a high-throughput screening pro- tocol to investigate the activity of non-ionic surfactants, with a broad range of hydrophilic–lipophilic balance values, against ABCB1-mediated efflux transport and…
Mucus penetrating properties of soft, distensible lipid nanocapsules
Designing nanomaterials to release their drug pay-load upon exposure to an exogenous trigger can help to direct drug delivery, but how the triggered release, which often modifies the nanomaterial properties, influences the biological fate…
Valtris Specialty Chemical’s Ohio site receives EXCiPACT GMP certification
EXCiPACT asbl is pleased to announce that the Valtris Specialty Chemical site in Cleveland, Ohio has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies. The…
DuPont develops novel excipient designed to better stabilize biologics
As biologics continue to expand in the marketplace, they present a unique array of challenges for producers compared to conventional small molecule drugs. The suite of functional excipients for biologics is limited in comparison to those…
Excipients for Direct Compression – Content Uniformity in Directly Compressed Formulations
Fuji Chemical Technical Newsletter
The use of direct compression continues to increase due to permitting formulations with heat & moisturesensitive active pharmaceutical ingredients (APIs).However, APIs which have been finely ground…
Dual Sustained Release Matrix
in this video you discover how dual matrix containing two sustained release(SR) agents, Compritol® 888 ATO and HPMC enables the production of robust SR tablets.
With dual matrix, you can:
reduce the SR agent concentration…
SEDDS for intestinal absorption of insulin
To face the challenges of oral delivery of peptide and protein drugs (P/P drugs), self-emulsifying drug delivery systems (SEDDSs) containing monoacyl phosphatidylcholine (MAPC), Labrasol (LAB) and medium-chain (MC) monoglycerides as…
Evaluation of improved oral bioavailability of ritonavir nanosuspension
The main objective of this study was to evaluate the pharmacokinetics of ritonavir (RTV) nanosuspension in rats in both fed and fasted state in comparison with coarse powder, physical mixture and commercial product (Norvir®). The point to…
Model-based description of disintegration time and dissolution rate of nanoparticle-loaded…
The embedding of nanoparticles in orodispersible films (ODFs) is an innovative strategy to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (API). As the films are supposed to disintegrate within seconds…
Roles of Excipients
Excipients have different roles in a formulation. Some of the main ones include:
Aid in the processing of the drug delivery system during its manufacture
Protect, support, or enhance stability, bioavailability, or patient…
Enhanced intestinal lymphatic absorption of saquinavir through supersaturated self-microemulsifying…
The therapeutic potential of saquinavir, a specific inhibitor of human immunodeficiency virus (HIV)-1 and HIV-2 protease enzymes, has been largely limited because of a low solubility and consequnt low bioavailability. Thus, we aimed to…
Pickering particle and emulsifier co-stabilised emulsions produced via rotating membrane…
Producing stable particle-stabilised emulsions of small droplet sizes and high monodispersity via membrane emulsification approaches is hindered by the poor mixing environment during processing and the low diffusivity and minimal…
A quick reference to plant gums and mucilages used as a tablet binder
Binders are the ingredients used in tablet granulation process for tablet cohesiveness. This confirms the tablet remains intact after compression. The development of new excipients for potential use as a binding agent in tablet formulations…
Polymer Distribution and Mechanism Conversion in Multiple Media of Phase-Separated…
Phase-separated films of water-insoluble ethyl cellulose (EC) and water-soluble hydroxypropyl cellulose (HPC) can be utilized to tailor drug release from coated pellets. In the present study, the effects of HPC levels and the pH, type,…
Case Studies on Lipid Excipients
If you need technical information and practical tips to formulate with your lipid excipients, Gattefossé has prepared different case studies for download after registration.
How to obtain sustained release tablets of metformin…
Characterisation and optimisation of diclofenac sodium orodispersible thin film formulation
Oral Thin Film (OTF) is a newly emerging drug delivery system which has many benefits for patients. Although there has been some formulation of OTF products, these have mainly been as confectionary or dental health products. The most…
Applications of Excipients in the Field of 3D Printed Pharmaceuticals
The aim of this study was to determine the effect of varying excipient content on the formation and physical properties of 3D printed tablets. Fifteen different excipient preparations were formed into tablets with radii of 5 mm and…
Drug Product Development for Older Adults – Multiparticulate Formulations
The multiparticulate drug product concept covering micropellets, pellets,and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability…
A Clean Label Definition
A definition of clean product labelling or "clean label" for food. How can I find out for myself whether my product meets all the requirements for clean labelling? Experts from BIOGRUND have put together a definition.
Background to the…
Complex formulations, simple techniques: Can 3D printing technology be the Midas touch in…
3D printing is a method of rapid prototyping and manufacturing in which materials are deposited onto one another in layers to produce a three-dimensional object. Although 3D printing was developed in the 1980s and the technology has found…
Natural Printing Ink for Food and Nutraceuticals
Due to fast growth of clean label movement, the term natural colour was defined by “Regulation (EC) No 1333/2008” which explains the detailed rules on the use of food additives. This regulation was updated in 2010 (Commission Regulation…
Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P…
Amit Raj Sinha, MD & CEO of Sigachi conferred the Business Leader of the year 2018
Taj Lands End, Mumbai, 16 Feb 2019. Amit Raj Sinha, MD & CEO, Sigachi Industries Private Limited was declared Business Leader of the Year at an event organized by Business Television India
The Business Leader of the year to Amit Raj…
Non-aqueous formulations for ram and screen extrusion-spheronisation
The use of non-aqueous cellulose-based formulations for extrusion-spheronisation (E-S) is investigated. A 10 wt% hydroxypropyl cellulose/isopropyl alcohol solution (HPC/IPA) was identified as a suitable sticky liquid binder for preparing…
New Possibilities for Pharmaceutical Excipients Analysis
An alternative method for the determination of total chlorine content in hydroxypropyl cellulose (HPC) was applied, combining a recently developed system based on a combustion step followed by pyrohydrolysis reaction. Using this approach it…
Sigachi receives “National Best Employer BRANDS 2018” Award
Taj Lands End, Mumbai, 16 Feb 2019. One of the leading excipient manufacturer, Sigachi, announced the receipt of the highly coveted National Best Employer Brands 2018 in the 13th Employer Branding Awards, organized as part of 27th edition…
Optimization of Coating Processes of Mini Tablets with Polyvinylpyrrolidone Solutions in an Acoustic…
The aim of the current study is to optimize the bed fluidized coating process of mini tablets by means of an acoustic levitator. The optimized coating parameters, which have to be set in a fluidized bed reactor, can be determined by means…
Visualizing the Future of the Pharma Market
Around the world, people are living longer.
By 2050, there will be two billion people that are 60 years or older globally. Meanwhile, the amount of seniors (65+ years old) in the U.S. will double to 100 million by 2060.
To meet the…
Excipients – The Good the Bad and The ugly Ep 192 – The ATP Project
In this episode of the ATP Project – Excipients – The Good The Bad And The Ugly. Matt, Jeff, and Steve discuss the excipients used in the industry, why excipients are used often in the process of manufacturing to limit damage to machinery…
Study of the design and characterization of new bisoprolol fumarate tablet formulations
The purpose of the study was to develop sustained release tablets containing bisoprolol fumarate and an innovative combination of Precirol ATO5 and hydroxypropyl methylcellulose, in order to conclude upon: properties of pharmaceutical…