Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Comparison of the liquisolid technique and co-milling for loading of a poorly soluble drug in…
Abstract
Drug loading into mesoporous carriers may help to improve the dissolution of poorly aqueous-soluble drugs. However, both preparation method and carrier properties influence loading efficiency and drug release. Accordingly, this…
Statistical Optimization of Fast Dissolving Tablet Contains Isosorbide Dinitrate for the Treatment…
Abstract
The ultimate objective about this experiment was to create a fast-dissolving tablet Isosorbide dinitrate that released its medication quickly. The physical properties of tablets, such as hardness, angle of repose, weight…
Amorphization of Low Soluble Drug with Amino Acids to Improve Its Therapeutic Efficacy: a…
Low aqueous solubility of drug candidates is an ongoing challenge and pharmaceutical manufacturers pay close attention to amorphization (AMORP) technology to improve the solubility of drugs that dissolve poorly. Amorphous drug typically…
Characterizing a design space for a twin-screw wet granulation process: A case study of…
Abstract
Twin-screw wet granulation is an emerging continuous manufacturing technology for solid oral dosage forms. This technology has been successfully employed for the commercial manufacture of immediate-released tablets. However, the…
Minerals as Excipients – Dr. Paul Lohmann
The major component of ingredients in pharmaceutical products in terms of volume is not the active ingredient itself, it is the excipient. Excipients assist in the administration of an ‘active’ substance that typically may not be easily…
Comprehensive Evaluation of Polymer Types and Ratios in Spray-Dried Dispersions: Compaction,…
Abstract
Amorphous solid dispersion (ASD) is a well-established strategy for enhancing the solubility and bioavailability of poorly soluble drugs. A significant portion of ASD products are in tablet form. However, the influence of common…
Pharmaceutical Formulations for Older Patients – Part 2
See the new book, edited by Mine Orlu, Fang Liu
Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients
Details reasons for applying advanced pharmaceutical technologies for the…
Microneedle-Mediated Transdermal Delivery of Genetic Materials, Stem Cells, and Secretome: An Update…
Abstract
Medical practitioners commonly use oral and parenteral dosage forms to administer drugs to patients. However, these forms have certain drawbacks, particularly concerning patients’ comfort and compliance. Transdermal drug delivery…
Lactalis CPHI Barcelona Trends Report
From the 24th to the 26th of October 2023, the CPHI was held in Barcelona for 3 days of collaboration and innovation on the pharmaceutical market. During Lactalis Ingredients Pharma’s first participation to the event, the Marketing and…
Comparative Dissolution of Budesonide from Four Commercially Available Products for Oral…
ABSTRACT
Budesonide is a corticosteroid regularly used in oral formulations to treat various inflammatory diseases in the
gastrointestinal tract, such as Crohn’s disease and ulcerative colitis. Budesonide has also been formulated to be…
3D Printing Emerging Technologies and Functionality of Polymeric Excipients in Drug Product…
See the new book, edited by Michael A. Repka, Nigel Langley
Covers regulatory and manufacturing aspects of 3D printing in drug development
Particular focus on hot melt extrusion and extruded filaments suitable for optimizing 3D…
The Impact of Formulation and Freeze Drying on the Properties and Performance of Freeze-Dried…
Freeze drying is a commonly used method for preserving probiotic bacteria and live biotherapeutic products. Before drying, the bacterial cells are formulated with a lyoprotectant, and the design of these two process steps are crucial to…
Viatel™ Bioresorbable Polymers – by Ashland
Ashland is a premier global specialty chemicals company serving customers in a wide range of consumer and industrial markets. With the Viatel™ platform, Ashland offers five families of bioresorbable polymers for parenteral controlled…
Polymer selection for amorphous solid dispersion of a new drug candidate by investigation of drug…
The antitumor drug candidate X-05 is being developed as an innovative anti-lung cancer drug candidate due to its excellent antitumour activity. A Caco-2 cell permeability study and solubility study confirmed that X-05 belonged to BCS class…
Pharmaceutical Formulations for Older Patients – Part 1
See the new book, edited by Mine Orlu, Fang Liu
Provides a better understanding on the EMA reflection paper on pharmaceutical development for older patients
Details reasons for applying advanced pharmaceutical technologies for the…
Preparation of Hot-Melt-Extruded Solid Dispersion Based on Pre-Formulation Strategies and Its…
In this study, an amorphous solid dispersion containing the poorly water-soluble drug, bisacodyl, was prepared by hot-melt extrusion to enhance its therapeutic efficacy. First, the miscibility and interaction between the drug and polymer…
Raw Material Variability in Biomanufacturing: A Case Study Using Poloxamer 188
Introduction & Aim
Media for cell culture has evolved from recipes containing plant or animal-derived products, to fully chemically defined (CD) formulations as an effort to reduce variability in bioprocess performance due to raw…
Enhancing the solubility and dissolution rate of piperine via preparation of piperine–hydroxypropyl…
Abstract
Context:
Piperine is the main secondary metabolite isolated from the family Piperaceae. This biologically active ingredient has many pharmacological effects, though its low water solubility limits its absorption in…
Manufacturing classification system for oral solid dosage forms of traditional Chinese medicines(Ⅰ):…
Oral solid dosage (OSD) occupies a key position in the market of Chinese patent medicines and new traditional Chinese medicines. Processing route is the foundation for the research and development of traditional Chinese medicine OSDs. On…
Recent advances in biopolymer-based mucoadhesive drug delivery systems for oral application
Oral drug delivery is a common and convenient route for administering pharmaceuticals, but it presents challenges related to drug stability, absorption, and targeted delivery. Because of their potential to address these challenges,…
Particle circulation and coating in a Wurster fluidized bed under different geometries
Abstract
The performance of particle coating is essentially determined by the morphology and uniformity of coating shells, which significantly depend on particle circulation. In this study, the geometry of a Wurster fluidized bed is…
Ph. Eur. pre-publishes revised Propylene glycol monograph
The revised monograph on Propylene glycol (0430) was adopted by the European Pharmacopoeia Commission (EPC) at its 177th session held on 21 and 22 November 2023. The monograph was revised in response to the public health risk posed by the…
Vaccines for a more sustainable future
Climate change is upon us, and we don’t have to look far to find its fallout. Summers are warmer, sea levels are rising and it’s almost impossible to look at the news without encountering a new case of severe weather damage. Heat waves,…
Low melting mixtures: Neoteric green solvents for flavor formulation
Abstract
Flavors are considered among the most valuable ingredients in any formula. However, aromatic substances are volatile and can be lost during processing and storage. Thus, it is beneficial to develop strategies for their retention…
Nanocrystals and nanosuspensions: an exploration from classic formulations to advanced drug delivery…
Nanocrystals and nanosuspensions have become realistic approaches to overcome the formulation challenges of poorly water-soluble drugs. They also represent a less-known but versatile platform for multiple therapeutic applications. They can…
Dispensing Oral Temozolomide in Children: Precision and Stability of a Novel and Ready to Use Liquid…
Abstract
Temozolomide (TMZ) is part of the therapeutic armamentarium used in managing pediatric cancers; however, available oral forms (capsules) are not adapted for use in children. Our aim was to assess the dose accuracy and stability of…
Effect of Powdered Cellulose Nanofiber with Different Particle Sizes on the Physical Properties of…
Abstract
Direct compression is a tableting technique that involves a few steps in non-demanding manufacturing conditions. High strength and rapid disintegration of tablet formulations were previously achieved through the addition of…
Interaction of thermal and rheological parameters critical for the processability of polyvinyl…
Purpose
Hot melt extrusion (HME) is a pivotal pharmaceutical manufacturing process employed to enhance the bioavailability of poorly soluble active pharmaceutical ingredients (APIs) in oral dosage forms. Often the applicability of the…
3D-printed prednisolone phosphate suppositories with tunable dose and rapid release for the…
Established medicines are often not tailored to the needs of the pediatric population, causing difficulties with administration or dosing. Three-dimensional (3D) printing technology allows novel approaches for compounding of personalized…
Nintedanib solid lipid nanoparticles improve oral bioavailability and ameliorate pulmonary fibrosis…
Nintedanib (NIN) and pirfenidone are the only approved drugs for the treatment of Idiopathic Pulmonary Fibrosis (IPF). However, NIN and pirfenidone have low oral bioavailability and limited therapeutic potential, requiring higher dosages to…
The importance of Excipient selection for modified release formulations – prevent the risk for…
Introduction
The oral route is the main acceptable route, which offers more patient compliance and cost-effective manufacturing processes. Pharmaceutical dosage forms may be developed in which drug release characteristics with respect to…
Experimental design approach for Development of Carboplatin Loaded Chitosan Modified Liposomal…
One of the most prevalent cancers affecting women globally is cervical cancer. Cervical cancer is thought to cause 570.000 new cases annually, and standard treatments can have serious side effects. In this work main aim is to design,…
Solusomes (novel Soluplus® enriched nano-vesicular carriers) for improving the oral bioavailability…
Candesartan cilexetil (CAN) is administered for treating hypertension and heart failure. CAN suffers poor oral bioavailability, owing to limited aqueous solubility, and first-pass metabolism. Solusomes (novel Soluplus® enriched…
Supercritical fluid technology as a strategy for nifedipine solid dispersions formulation: in vitro…
Abstract
Supercritical fluid technology (SFT) is an insufficiently investigated approach for the production of solid dispersions, it is environmentally acceptable and has a high potential for application in the pharmaceutical industry. The…