Deciphering the Role of Plasticizers and Solvent Systems in Hydrophobic polymer coating on Hydrophilic core
Abstract
The type of plasticizer and the choice of solvent or co-solvents used for coating of a hydrophilic core can greatly impact the permeability, porosity, and mechanical strength of the polymer film. Although, Ethylcellulose (EC) is an old polymer, it is a polymer of choice for modifying the drug release due to its inherent properties. The…
A Study on the Applicability of Multiple Process Analysers in the Production of Coated Pellets
Process analytical technology (PAT) has become an important factor in design, analysis and control of complex technological processes. In the present study, pellet coating process was monitored using four different PAT approaches, i.e.…
Gliding performance of solid oral dosage form film coatings using an artificial mucous layer
Oral drug delivery technology is mainly provided in the form of solid oral dosage forms (SODF) that have to be swallowed intact and move throughout the oro-esophageal system to release the drug content in the stomach or intestine. As there…
A single-layer film coating for colon-targeted oral delivery
Most pH-sensitive polymer coating studies for potential colonic delivery systems apply multiple layers to protect the active agent from degradation and early release in the stomach and small intestine. This study designed a single-coat…
Discover galenIQ™, BENEO’s highly functional filler and binder
galenIQTM is a highly functional filler and binder - Learn more about galenIQTM in this Video
galenIQTM is a highly functional filler and binder, characterized by its ease of use and applicability to a wide range of solid and liquid…
Effects of Drug-Polymer Interactions on Tablet Properties During the Development of Abuse-Deterrent…
The objective of the present study is to understand the effects of drug-PEO interactions during the thermal treatment of polyethylene oxide (PEO)-based, directly compressed, abuse-deterrent formulations (ADFs). The drugs studied were…
Congruent release of drug and polymer: A “sweet spot” in the dissolution of amorphous solid…
Liquid-liquid phase separation (LLPS) occurs following amorphous solid dispersion (ASD) dissolution when the drug concentration exceeds the “amorphous solubility”, and is emerging as an important characteristic of formulations that may…
Porous and highly dispersible voriconazole dry powders
Systemic administration of antifungal agents for the treatment of pulmonary aspergillosis is limited by the poor lung deposition and severe adverse effects. In contrast, pulmonary delivery allows a higher amount of drug to be delivered…
Excipient Topics at Making Pharmaceuticals – Day 1
Making Pharmaceuticals takes places April 30 - May 1 2019 and as every year covers a wide range of topics around excipients such as:
How to Implement Appropriate GMPs In An Excipients Manufacturing Site
How EXCiPACT Certification Adds…
Oral delivery of insulin via mesoporous carbon nanoparticles
In this article, a new type of mesoporous carbon nanoparticles (MCN) was fabricated as a potential oral delivery system of insulin to reduce the adverse reactions by hypodermic injection. The mesoporous carbon nanoparticles-carried insulin…
Bioavailability enhancement of poorly soluble drugs: The holy grail in pharma industry
Bioavailability, one of the prime pharmacokinetic properties of a drug, is defined as the fraction of an administered dose of unchanged drug that reaches the systemic circulation and is used to describe the systemic availability of a drug.…
Overcoming Poor Tabletability of Bulky Absorption Enhancers by Spray Drying Technology
Absorption enhancers are often a major component of solid oral peptide formulations as compared to the active pharmaceutical ingredient and excipients. This commonly results in poor tabletability that is hard to mitigate in direct…
Determination of Impurities in Pharmaceuticals: Why and How?
The presence of impurities, particularly the API-related impurities, i.e., degradation-related impurities (DRIs) and interaction-related impurities (IRIs), may affect the quality, safety, and efficacy of drug products. Since the regulatory…
Use of roller compaction and fines recycling process in the preparation of erlotinib hydrochloride…
This study focuses on improving the manufacturing process for a generic immediate-release tablet containing erlotinib hydrochloride by adding a fines recycling process during roller compaction. Due to the large fraction of small-sized API…
Novel Excipients – USP Wants Your Input!
USP is seeking stakeholder input on the topic of Novel Excipients. This survey seeks to identify the views of stakeholders on the current state of innovation in excipients and if there is a link to current and future challenges in…
Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable…
To improve the dissolution and oral bioavailability of valsartan (VST), we previously formulated a supersaturable self-microemulsifying drug delivery system (SuSMED) composed of Capmul® MCM (oil), Tween® 80 (surfactant), Transcutol® P…
Development of oral foams for topical treatment of inflammatory bowel disease
The advantages of local therapy for the treatment of inflammatory bowel disease (IBD) are generally accepted. However, the effectiveness of such treatment is often limited due to insufficient targeting of the inflammatory lesions using…
Electrospinning – Article series by pharmaexcipients.com
Electrospinning can be an interesting downstreaming continuous manufacturing technology. Pharmaexcipients.com lately published a series of articles from MDPI adressing this topic.
You can access the article series on electrospinning here …
Titanium dioxide free coatings – Biogrund information
For decades, titanium dioxide (TiO2) has been used as a white pigment due to its very high opacity and brightness. Therefore, it has a wide range of applications, from being a colouring ingredient of pharmaceutical film coating, to food…
Storage stability of inhalable phage powders containing lactose at ambient conditions
The aim of this study was to evaluate the storage stability of inhalable phage powders containing lactose and leucine as excipient. As an FDA-approved excipient for inhalation, lactose is preferred over other sugars. PEV phages active…
Lipid Excipients for Cannabinoid Drug Products
The introduction of the cannabis plant into Western medicine dates to the 19th century when the plant was first used as an additive to patented medicines. The development of cannabis based therapies in the modern sense however came to a…
Enter the Making Pharmaceuticals Awards!
Making Pharmaceuticals will host over 2,000 visiting pharma professionals over two days, and 200+ exhibitors from across Europe who gather at the event to meet, network, generate business and take advantage of more than 90 free to attend…
New EXCiPACT Certifications for JRS PHARMA sites in Germany and India
JRS PHARMA announces new EXCiPACT Certifications for the Microcrystalline Cellulose (MCC) Manufacturing Site in Weißenborn, Germany, along with MCC and Superdisintegrant Manufacturing Sites in India. Full press release
Effect of melt extrudability and melt binding efficiency of Soluplus® on release pattern of…
The present study explores the effect of melt binding of Soluplus® on in vitro release profiles of two hydrophilic drugs, metformin hydrochloride, and paracetamol. The melt viscosities of bulk polymer and physical mixtures with different…
Roller compaction: Ribbon splitting and sticking
Roller compaction is the main technique employed in dry granulation. Ribbon sticking and splitting are among the major factors that can hinder the use of this process for some formulations. Ribbon splitting can occur either transversally…
CPhI China – VIP registration
As one of the most comprehensive pharmaceutical exhibition in Asia, CPhI & P-MEC China has, since its launch in 2001, been fostering international pharmaceutical business exchanges and leading market trends and technical innovations in…
Model-based Approach to the Design of Pharmaceutical Roller-Compaction Processes
This work presents a new model based approach to process design and scale-up within the same equipment of a roller compaction process. The prediction of the operating space is not performed fully in-silico, but uses low-throughput…
Mucoadhesive approach for buccal application: Preactivated chitosan
Buccal adhesive drug delivery has gained pharmaceutical interest in the past decades. This study aimed to establish an efficient mucoadhesive dosage form based on chitosan for the potential use in buccal application. Mercaptonicotinic acid…
Cyclodextrins as multifunctional excipients
A novel approach for drug design based on the oral carbapenem analog tebipenem pivoxil (TP) has been proposed. The formation of the tebipenem pivoxil-β-cyclodextrin (TP-β-CD) complex resulted in changes concerning physicochemical properties…
Novel Inhalable Ciprofloxacin Dry Powders for Bronchiectasis Therapy
Non-cystic fibrosis bronchiectasis (NCFB) is a chronic respiratory disease associated with the high morbidity and mortality. Long-term intermittent therapy by inhalable antibiotics has recently emerged as an effective approach for NCFB…
Pharma & Biotech Deals 2018 – more to come in 2019
In 2018, each month PharmaCompass published PharmaFlow — a compilation of all the major deals in the industry that took place in the preceding month. We begin 2019 with our annual compilation of the deals of 2018, packed with some exciting…
Influence of Immediate Release Tablet Formulation on Dissolution Profile of Paracetamol
Introduction: Paracetamol is analgesic and antipyretic, which is usually in the form of an immediate release tablet formulations. Therapeutic effects in terms of the speed and intensity of the analgesic effect is dependent on speed of…
A new melatonin oral delivery platform based on orodispersible films
An innovative delivery system for melatonin, based on the incorporation of solid lipid microparticles in orodispersible films (ODFs) made of maltodextrin, was designed and developed. Lipid microparticles at two different melatonin…
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
The electrospinning process has gained popularity due to its ease of use, simplicity and
diverse applications. The properties of electrospun fibers can be controlled by modifying either
process variables (e.g., applied voltage, solution…
Efficacy of a novel LyP-1-containing self-microemulsifying drug delivery system (SMEDDS) for active…
An ideal cancer therapy targets the tumor cells selectively without damaging healthy tissues. Even though the tumor-specific markers are limited, these molecules can be used for the delivery of anti-cancer drugs as an active targeting…