Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems
Site-specific colon drug delivery is a practical approach for the treatment of local diseases of the colon with several advantages such as rapid onset of action and reduction of the dosage of the drug as well as minimization of harmful side…
Formulation development of a continuously manufactured orodispersible film
Continuously manufactured orodispersible films (ODFs) offer a promising approach for individualized therapy with an easy to administer solid dosage form. The aim of this study was to develop a long ODF containing warfarin sodium to enable…
Development of A New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis…
Psoriasis is a chronic autoimmune systemic disease with an approximate incidence of 2%
worldwide; it is commonly characterized by squamous lesions on the skin that present the typical
pain, stinging, and bleeding associated with an…
Current Developments in Excipient Science – Implication of Quantitative Selection of Each…
Implication of Quantitative Selection of Each Excipient in Product Development
Excipients’ role in designing different dosage forms does not require any introduction. These are the additives that are added to the formulation along with…
Solid nanoparticles for oral antimicrobial drug delivery
Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health…
In vitro drug release from acetylated high amylose starch-zein films for oral colon-specific drug…
This study describes the preparation of free films of zein with and without acetylated high amylose maize starch (HAS) and their corresponding coated tablets as a novel approach to colonic drug delivery. We hypothesise that the embedding of…
Fast Dissolving of Ferulic Acid via Electrospun Ternary Amorphous Composites Produced by a Coaxial…
Enhancing the dissolution of insoluble active ingredients comprises one of the most
important issues in the pharmaceutical and biomaterial fields. Here, a third generation solid
dispersion (3rd SD) of ferulic acid was designed and…
Loading of Porous Functionalized Calcium Carbonate Microparticles
Accurate analysis of intraparticle distribution of substances within porous drug carriers is important to optimize loading and subsequent processing. Mercury intrusion porosimetry, a common technique used for characterization of porous…
Solid nanoparticles for oral antimicrobial drug delivery: a review
Most microbial infectious diseases can be treated successfully with the remarkable array of antimicrobials current available; however, antimicrobial resistance, adverse effects, and the high cost of antimicrobials are crucial health…
HiCel™ Silicified Microcrystalline Cellulose
HiCel™ is a versatile co-processed excipient with added-value to standard microcrystalline cellulose types. See this short video to get an overview of why you should consider HiCel™ in your formulation work:
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The Effect of Molecular Properties on Active Ingredient Release from Electrospun Eudragit Fibers
The formation of nanoscale fibers from pH-sensitive polymers is a route which has been widely explored for targeted drug delivery. In particular, the Eudragit L100 and S100 families of polymers have received significant attention for this…
Abuse Deterrent Immediate Release Egg-Shaped Tablet (Egglets) Using 3D Printing Technology
Opioid abuse is a growing problem and has become a national health crisis over the past decade in the USA. Oral ingestion, snorting, and injection are the most commonly employed routes of abuse for an immediate release product. To…
Application of Texture Analysis Technique in Formulation Development of Lyophilized Orally…
Orally disintegrating tablets (ODTs) attract a great attention as this easy swallowing dosage form often improves patient compliance. In the current work, orally disintegrating tablets comprising mannitol, polyvinylpyrrolidone (PVP) and an…
Homogenization of Amorphous Solid Dispersions Prepared by Electrospinning in Low-Dose Tablet…
Low-dose tablet formulations were produced with excellent homogeneity based on drug-loaded electrospun fibers prepared by single-needle as well as scaled-up electrospinning (SNES and HSES). Carvedilol (CAR), a BCS II class compound, served…
The use of Real-Time At-Line Particle Size Measurement on a Pelletization Process for Accurate…
The direct pelletization process is a fast and flexible operation with the potential to produce high quality particles appropriate for sophisticated oral solid dose formulations where a narrow Particle Size Distribution (PSD) is required.…
Design, formulation and manufacture of film-coated drug products
Film coating is a common step in tablet manufacture that can be used to improve product appearance, organoleptic properties, or to facilitate swallowing. Functional film coats can also be used as a part of the product’s stabilisation…
Pediatric Formulations: Knowledge Gaps Limiting the Expedited Preclinical to Clinical Translation in…
Traditionally, drug discovery and development research have been primarily focused on the mitigation of disease treatment for the general adult population, often overlooking the medical needs of pediatric patients. While remarkable progress…
Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited…
Taste Evaluation by Electronic Tongue and Bioavailability Enhancement of Efavirenz
Self-nanoemulsifying drug delivery systems (SNEDDS) are isotropic and thermodynamically stable mixtures of oil, surfactant, co-surfactant, and drug which emulsify spontaneously on contact with aqueous phase under mild agitation. Efavirenz…
Interpolymer complexes of Carbopol® 971 and poly(2-ethyl-2-oxazoline): physicochemical studies of…
Carbopol® 971 and poly(2-ethyl-2-oxazoline) form hydrogen-bonded interpolymer complexes in aqueous solutions and their complexation is strongly dependent on solution pH. This work investigated the complexation between these polymers in…
What are pharmaceutical film coatings? Part 1 -Tablets
There a many reasons for coating of different pharmaceutical products such as pellets, granules, capsules, powders and crystals. In this article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets is a…
Non-traditional application of drug and excipient
During formulation development, there are cases when, serendipitously, drug or excipients play a different role than intended one or a dual role. One of the examples of a non-traditional role is of a drug acting as a plasticizer.…
3D-Printed Isoniazid Tablets for the Treatment and Prevention of Tuberculosis—Personalized Dosing…
The aim of the present work was to produce 3D-printed oral dosage forms with a sufficient drug dose displaying various release profiles. Hot-melt extrusion was utilized to produce drug-loaded feedstock material that was subsequently…
The influence of ethanol on superdisintegrants and on tablets disintegration
Disintegration of immediate release tablets originates from the volume expansion of disintegrants within the formulation. Here, we study the impact of ethanol on the disintegrant expansion and on tablets disintegration. The three most…
Edible solid foams as porous substrates for inkjet-printable pharmaceuticals
The aim of this study was to investigate new porous flexible substrates, i.e., solid foams that would serve as a carrier with a high ink absorption potential for inkjet printable pharmaceuticals. Propranolol hydrochloride was used as a…
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its…
Chitosan-Based Mucoadhesive Vaginal Tablets for Controlled Release of the Anti-HIV Drug Tenofovir
Vaginal microbicides have the potential to give women at high risk of contracting HIV the option of self-protection by preventing the sexual transmission of the virus. In this paper, mucoadhesive vaginal tablets based on chitosan, alone and…
Lipids and polymers in pharmaceutical technology: lifelong companions
In pharmaceutical technology, lipids and polymers are considered pillar excipients for the fabrication of most dosage forms, irrespective of the administration route. They play various roles ranging from support vehicles to release rate…
Mannitol
Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction. Other widely known polyols are xylitol and sorbitol. Mannitol and sorbitol are isomers, differing only in the orientation of the hydroxyl group on…
Sustainable Application of Biopolymer
The widespread use of materials produced from petrochemical substrates, such as plastics, can exert an adverse impact on the environment, especially on creatures living therein, including fish and turtles in the sea, as well as the birds…
Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis
This study aimed to develop fluconazole loaded buccal mucoadhesive oral strip for local treatment of oral candidiasis. Oral strip was prepared by solvent casting method with different polymer combinations and evaluated for weight,…
Benefits of Using High-Functionality Excipients in a Continuous Process
Webcast PharmTech.com
In a continuous process, mono-functional excipients must be added through individual feeders, possibly resulting in multiple sources of variability. Alternatively, a single high-functionality co-processed excipient…
Sucrose
Sucrose is a non-reducing crystalline disaccharide made up of glucose and fructose, found in many plants but extracted as ordinary sugar mainly from sugar cane and sugar beets. Pfanstiehl Brand, High Purity Low Endotoxin Sucrose is used in…
The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone
Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying…