Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
Mannitol
Mannitol is classified as a sugar alcohol and is derived from a sugar (mannose) by reduction. Other widely known polyols are xylitol and sorbitol. Mannitol and sorbitol are isomers, differing only in the orientation of the hydroxyl group on…
Sustainable Application of Biopolymer
The widespread use of materials produced from petrochemical substrates, such as plastics, can exert an adverse impact on the environment, especially on creatures living therein, including fish and turtles in the sea, as well as the birds…
Formulation and evaluation of fluconazole loaded oral strips for local treatment of oral candidiasis
This study aimed to develop fluconazole loaded buccal mucoadhesive oral strip for local treatment of oral candidiasis. Oral strip was prepared by solvent casting method with different polymer combinations and evaluated for weight,…
Benefits of Using High-Functionality Excipients in a Continuous Process
Webcast PharmTech.com
In a continuous process, mono-functional excipients must be added through individual feeders, possibly resulting in multiple sources of variability. Alternatively, a single high-functionality co-processed excipient…
Sucrose
Sucrose is a non-reducing crystalline disaccharide made up of glucose and fructose, found in many plants but extracted as ordinary sugar mainly from sugar cane and sugar beets. Pfanstiehl Brand, High Purity Low Endotoxin Sucrose is used in…
The role of sodium alginate on the supersaturation state of the poorly soluble drug chlorthalidone
Solid dispersions (SDs) of chlorthalidone (CTD) are promising systems to enhance drug dissolution rate, generate and maintain drug supersaturation levels in gastrointestinal fluids. In this work, SDs of CTD were prepared by spray drying…
Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid…
The ‘repurposed drug,’ disulfiram (DSF), is an inexpensive FDA-approved anti-alcoholism drug with multi-target anti-cancer effect. However, the use of DSF in clinical settings remains limited due to its high instability in blood. In the…
The applicability of pharmaceutical polymeric blends for the fused deposition modelling (FDM) 3D…
The three dimensional printing (3DP) in the pharmaceutical domain constitutes an alternative, innovative approach compared to the conventional production methods. Fused deposition modelling (FDM), is a simple, cost-effective 3DP technique,…
Addressing Material Properties in the Design of a Direct Compression Continuous -Webcast 2014
Virtually, all solid dosage forms in the pharmaceutical industry have been manufactured in ‘batch’ despite cost and processing disadvantages associated with manufacturing a product in batch mode. Market forces coupled with a conducive…
Trehalose
Trehalose is a non-reducing disaccharide consisting of two glucose molecules linked by an α, α–1,1 bond. Pfanstiehl Brand, High Purity Low Endotoxin Trehalose is used in the biopharmaceutical industry to stabilize proteins, lipids, and…
Effect of binder and load solubility properties on HPMC granules produced by wet granulation process
Hydroxypropyl methylcellulose (HPMC) is one of the most important hydrophilic ingredients used in hydrogel matrices preparation (tablets or granules). In this work, HPMC was used to produce granules loaded with hydrophilic and hydrophobic…
The renaissance of pellets is promoting innovative Technologies
In recent years, formulations based on pellets have been the trend. New technologies make it possible to circumvent property rights for active ingredients and are therefore very popular with pharmaceutical…
Glatt CPS® Technology: Case study
The Glatt CPS® Technology (Complex Perfect Spheres) is a fluid bed rotor technology for producing spherical matrix pellets with a smooth surface and high density. Typically, microcrystalline cellulose is used as a basic excipient for…
Zebrafish as a Preclinical In Vivo Screening Model for Nanomedicines
The interactions of nanomedicines with biological environments is heavily influenced by their physicochemical properties. Formulation design and optimization are therefore key steps towards successful nanomedicine development.…
Which methods are used for the analysis of taste masking?
This article covers the different possibilities to characterize and quantify the sensory atttributes of APIs and drug products. Although in-vitro techniques such as e-tongues are available, sensory analysis is still the definitive method to…
Understanding the release performance of pellets with hydrophobic inclusions in sustained-release…
The aim of this study was to evaluate how the addition of hydrophobic inclusions to sustained-release pellet film coat can affect drug release. Sustained-release formulations, in particular multiparticulate systems are gaining popularity…
Formulation of Dispersed Gliclazide Powder in Polyethylene Glycol–Polyvinyl Caprolactam– Polyvinyl…
Background: Oral bioavailability of gliclazide, a hypoglycemic drug, is hindered by its low aqueous solubility. Improvement of solubility will enhance dissolution rate and in turn the bioavailability. This research aimed to formulate the…
Effect of processing conditions and excipients on dehydration kinetics of sodium naproxen hydrate in…
The manufacture of oral dosage form may induce changes in the physical form of an active pharmaceutical ingredient. Once such example includes formation of hydrate during granulation followed by the reverse transition to the anhydrous form…
Surface engineered excipients: III. Facilitating direct compaction tableting of binary blends…
irect compaction tableting, a desired manufacturing option, is infeasible for blends containing fine cohesive poorly-compactable APIs at higher drug loadings. In this study, the feasibility of using fine, dry coated excipients is…
Evaluation of bulk compression using a discrete element procedure calibrated with data from triaxial…
Confined compression of bimodal mixtures of nearly monodisperse spherical cellulose acetate (CA) particles (diameters 1.5 and 2.0 mm) was studied numerically with the discrete element method (DEM) and experimentally using a materials tester…
Happy New Year from pharmaexcipients
We thank everybody in our network for your interest and support! Wishing you all a superb 2019 and happy to the ongoing exchange on excipients! Best wishes your pharmexcipients team
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Probing nanoliposomes using single particle analytical techniques: effect of excipients, solvents,…
There has been a steady increase in the interest towards employing nanoliposomes as colloidal drug delivery systems, particularly in the last few years. Their biocompatibility nature along with the possibility of encapsulation of…
The Role of Carriers in DPI Capsules
Choice of carrier can have a significant impact on the capsule filling process as well as the performance of the DPI formulation.
May 02, 2018 by Adeline Siew, PhD Pharmaceutical Technology, Volume 42, Issue 5, pg 30–33
The use of…
Production of dry-state ketoprofen-encapsulated PMMA NPs by coupling micromixer-assisted…
We present a two-step process to produce dry-state Ketoprofen-loaded poly(methyl methacrylate) nanoparticles (NPs) with controllable size and tunable drug release profile. A colloidal suspension of drug-loaded nanoparticles was first…
Managing active pharmaceutical ingredient raw material variability during twin-screw blend feeding
Continuous powder feeding is a critical step in continuous manufacturing of solid dosage forms, as this unit operation should ensure the mass flow consistency at the desired powder feed rate to guarantee the process throughput and final…
Recent trends and future perspective of pharmaceutical wet granulation for better process…
Current trends in pharmaceutical wet granulation have been shifted from traditional approach to systematic and modern approaches, enabling the production of highly engineered product. In this context, quality by design (QbD), modelling, and…
Potentially Harmful Excipients in Neonatal Medications: An Observational and Cross-Regional…
Objectives: We aimed to examine the administration of eight potentially harmful excipients of interest (EOI), including paraben, polysorbate 80, propylene glycol, benzoate, saccharin sodium, sorbitol, ethanol, and benzalkonium chloride, to…
Preparation and Evaluation of Ibuprofen Solid Dispersion Tablets with Improved Dissolution and Less…
The aim of this study was to prepare and evaluate Ibuprofen (IBU) solid dispersion tablets with improved dissolution and less sticking using Porous Calcium Silicate (PCS). Solid dispersion granules were prepared using water-based solid…
Controlled dual drug release by coaxial electrospun fibers – Impact of the core fluid on drug…
Controlled release of hydrophilic drugs from carriers is still faced with problems due to the poor compatibility of such substances with slowly degradable polymers leading to challenges regarding fabrication as well as undesired burst…
Article Choline-Amino Acid Ionic Liquids as Green Functional Excipients to Enhance Drug Solubility
The development of effective forms to incorporate poorly soluble drugs into delivery systems remains a problem. Thus, it is important to find alternatives such as finding excipients that increase drug solubility. Ionic liquids (ILs),…
Combined Approach of Cyclodextrin Complexation and Nanostructured Lipid Carriers for the Development…
The development of specific and age-appropriate pediatric formulations is essential to assure that all children and their care-givers can easily access to safe and effective dosage forms. The need for developing specific pediatric medicinal…
Novel Dissolution Method for Oral Film Preparations with Modified Release Properties
Oromucosal film preparations have gained popularity in pharmaceutical research and development. Therefore, oral films have been integrated into the monograph “oromucosal preparations” of the European Pharmacopeia in 2012. Regulatory…
Micro- and nanotechnology approaches to improve Parkinson’s disease therapy
Current therapies for Parkinson's disease are symptomatic and unable to regenerate the brain tissue. In recent years, the therapeutic potential of a wide variety of neuroprotective and neuroregenerative molecules such as neurotrophic…
Novel, Lean and Environment-friendly Granulation Method: Green Fluidized Bed Granulation (GFBG)
The Green fluidized bed granulation (GFBG) technology is based on the moisture activated dry granulation (MADG) technique and consists only of a mixing and spraying process using a fluidized bed granulator, requiring no heating process.…