Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Polyurethanes as New Excipients in Nail Therapeutics
Onychomycosis affects about 15% of the population. This disease causes physical and psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels, colloidal carriers, and nail lacquers) is usually the most…
Elastic recovery of filler-binders to safeguard viability of Lactobacillus rhamnosus GG during…
Tablets are increasingly explored as dosage form for oral probiotics, especially for applications such as pharyngitis and dental health. In such tablets, the dry form increases the stability and the shelf life of the product. In addition,…
Evaluation of calcium magnesium silicate-date palm cellulose as a potential tablet excipient
A new excipient was prepared using natural resources and bio-wastes such as sodium silicate, brine and date palm cellulose. The prepared excipient is water-insoluble silicate salt precipitated in date palm cellulose (WISS-DPC). The aim of…
Gender, Age, Race and Lactose Intolerance: Is There Evidence to Support a Differential Symptom…
Research evaluating the relationship between lactose intolerance (LI) symptoms and age, gender and race is reviewed. An exhaustive search was conducted on the Google Scholar and PubMed databases. The evidence suggests that women, the…
Evaluating superdisintegrants for their performance in orally disintegrating tablets containing…
Orally disintegrating tablets (ODTs) are gaining importance and popularity due to their numerous advantages. Lysozyme, an enzyme with antibacterial properties, is currently only available as a conventional tablet and syrup. The main aims of…
Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development
"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by…
Impact of material properties and process variables on the residence time distribution in twin screw…
Screw feeders are integrated as dispensing units in most continuous manufacturing platforms. Hence, characterizing and modelling the residence time distribution (RTD) of materials in feeders is indispensable to understand the traceability…
Individualized in vitro and in silico methods for predicting in vivo performance of enteric-coated…
The efficacy of narrow therapeutic index (NTI) drugs is closely related to their plasma concentration-time profile. Particularly for these compounds interindividual variability of gastrointestinal (GI) parameters relevant to in vivo drug…
Evaluation of in-line particle measurement with an SFT-probe as monitoring tool for process…
The Process Analytical Technology (PAT) initiative published by the Food and Drug administration (FDA) describes PAT systems as important tools to optimize pharmaceutical processes in order to ensure the final product quality. Real-time…
Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the…
The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including…
Probing the impact of HPMC viscosity grade and proportion on the physical properties of…
This study investigated the impact of hydroxypropyl methylcellulose (HPMC) viscosity grade, HPMC proportion and particle size fraction on the physical properties of the freeze-dried mannitol-HPMC excipients produced, using multivariate…
Chemically identical but physically different: a comparison of spray drying, hot melt extrusion and…
In spite of the large research efforts in the past two decades, it is still difficult, if possible at all, to predict what manufacturing technology will lead to the best amorphous solid dispersions (ASDs) in terms of drug to polymer ratio…
Roquette acquires a majority stake in Crest Cellulose
La Madeleine (France), 12 December 2018 – Roquette, a global leader in plant-based ingredients for Food, Nutrition and Health markets, announced today the completion of the acquisition of a majority stake in Crest Cellulose, from Pravesha…
Enhancement of saquinavir absorption and accumulation through the formation of solid drug…
Nanotechnology is now considered a promising drug delivery method for orally administered hydrophobic drugs to their sites of action. The effect of nanodispersion on cellular transport and accumulation of saquinavir (SQV) was…
Identifying critical process steps to protein stability during spray drying using a vibrating mesh…
The aim of this study was to identify critical steps to protein stability during spray drying using two different nozzle types: a vibrating mesh nozzle and a standard two-fluid nozzle in a Büchi B-90 spray dryer. l-Lactic dehydrogenase was…
Can Drug Release Rate from Implants Be Tailored Using Poly(urethane) Mixtures?
Hydrophobic and hydrophilic thermoplastic poly(urethane) (TPU) mixtures offer the opportunity to tune water swelling capacity and diffusion rate for drugs exhibiting broadly different properties. We sought to (1) assess the range of drug…
Four Dow USA sites receive EXCiPACT GMP certification as pharmaceutical excipient suppliers
EXCiPACT asbl is pleased to announce that four Dow USA sites have each been awarded an EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally-recognised Certification Bodies. The Certificates demonstrate that
Dow Midland…
Thermodynamic and kinetic evaluation of the impact of polymer excipients on storage stability of…
Two pharmaceutical polymers with high glass transition temperatures (Tg>100°C), polyvinylpyrrolidone-vinyl acetate copolymer (PVPVA) and hydroxypropyl methylcellulose acetate succinate (HPMCAS), have been assessed for their impact on the…
Peptide Optimization at the Drug Discovery-Development Interface: Tailoring of Physicochemical…
Physicochemical properties of peptides need to be compatible with the manufacturing process and formulation requirements to ensure developability towards the commercial drug product. This aspect is often disregarded and only evaluated late…
Freeze/thaw of IGG solutions
In this communication, the effect of mannitol and trehalose crystallization on the unfolding of IgG1, a monoclonal antibody, in the frozen state with repeat freeze/thaw under different pH conditions was explored. Formulations were annealed…
Application of 3D printing technology and quality by design approach for development of…
Pediatric population is a sensitive sector of the healthcare and pharmaceutical field with additional needs compared to the adult population. Extemporaneous formulations for children are generally prepared by manipulating adult…
Solidification to Improve the Biopharmaceutical Performance of SEDDS: Opportunities and Challenges
Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the…
Variability of Magnesium Stearate
The objective of this study is to investigate the variability in physiochemical and spectral properties of commercially available vegetable grade Magnesium Stearate (MgSt) samples, and to assess the correlation between physiochemical…
Overcoming Solubility Challenges: Exploring the Lipids Option
Live Multimedia PresentationThursday, December 13, 2018 at 2pm EST • 1pm CST • 11am PST
Event OverviewAs more molecules in development prove to be highly insoluble, formulators are exploring new alternatives that offer the desired…
Whey proteins as stabilizers in amorphous solid dispersions
Whey proteins are extensively used as nutritional supplements but have so far not been investigated as co-formers for amorphous solid dispersions (ASD) to enhance the solubility and dissolution rate of poorly water soluble drugs. In this…
3D printed elastic mould granulation
In the pharmaceutical industry, enhanced process understanding resulting in superior control of product attributes, has the potential to save up to 20% of process engineering and product development costs during drug development. With the…
Accelerated Development – Upgrade your existing Glatt Fluid Bed Processors with PAT tools
Do you want to accelerate, improve and optimize your product development?
Are you looking for improved process understanding?
Innopharma Technology and Glatt have joined forces to offer existing users of the Glatt Lab Scale…
The new USP Microcrystalline Cellullose Monograph – PDF Download available
The revision to the harmonized standard for Microcrystalline Cellullose has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 4 (former Stage 6) of the PDG process,…
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its…
3rd European Conference on Pharmaceutics
Bologna from 25 to 26 March 2019
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Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique
Abstract: Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl…
A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing
A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar,…
Dynamic Properties of Novel Excipient Suggest Mechanism for Improved Performance in Liquid…
To improve liquid formulation stability, formulators employ various excipients designed to stabilize protein drugs, including buffers, salts, sugars, and surfactants. One of the roles of surfactants is to protect the protein drug from…
Microcrystalline Cellullose – Notice of Adoption of Harmonized Standard
The revision to the harmonized standard for Microcrystalline Cellullose has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 4 (former Stage 6) of the PDG process,…