Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
Evolution of the Microstructure of Sustained-release Matrix Tablets during Dissolution and Storage
Glyceryl behenate based-matrix tablets allowed obtaining a sustained release of theophylline for up to 12 hours. The diluent selected as pore-forming agent (lactose or dibasic calcium phosphate anhydrous) affected the drug release and its…
3rd European Conference on Pharmaceutics
Bologna from 25 to 26 March 2019
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Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique
Abstract: Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl…
A Feasibility Study on HPMC-Improved Sulphoaluminate Cement for 3D Printing
A novel 3D printing material based on hydroxypropyl methylcellulose (HPMC)—improved sulphoaluminate cement (SAC) for rapid 3D construction printing application is reported. The hydration heat, setting time, fluidity of paste and mortar,…
Dynamic Properties of Novel Excipient Suggest Mechanism for Improved Performance in Liquid…
To improve liquid formulation stability, formulators employ various excipients designed to stabilize protein drugs, including buffers, salts, sugars, and surfactants. One of the roles of surfactants is to protect the protein drug from…
Microcrystalline Cellullose – Notice of Adoption of Harmonized Standard
The revision to the harmonized standard for Microcrystalline Cellullose has been approved by the Pharmacopeial Discussion Group (PDG) as described in its PDG sign-off cover sheet. Having reached Stage 4 (former Stage 6) of the PDG process,…
Formulation and Manufacturing of Solid Dosage Forms
As solid dosage forms remains the primary option when developing a drug product, it was felt by the guest editors that the need to have a special issue on formulation and manufacturing of solid products could not be overstated. We have seen…
Excipients in children’s medicines
This leaflet offers advice about the common ingredients used to make up children’s medicines. These ingredients are called ‘excipients'
All forms of medicine contain ingredients as well as the drug – these are called excipients.…
To use Talc or not to use Talc: Should this even be a Question?
Magnesium silicate (MgSiO3) when hydrated is most commonly known as “Talc”. In the pharmaceutical industry, talc is used primarily as a glidant to improve powder flow in tablet compression. Of course, talc is also used by the personal care…
The Coming of Age of Amorphous Solid Dispersions
Although the majority of new drug candidates suffer from poor solubility and bioavailability, oral solid dosage forms remain the preferred route of administration due to their ease of use and convenience for patients and caregivers. In…
Liquisolid Systems: Understanding the impact of drug state (solution or dispersion), nonvolatile…
The drug in a solid dosage form must undergo dissolution before it is available for absorption from the gastrointestinal tract. Liquisolid system (LS) is a technology used for increasing aqueous solubility of the drugs, which has an…
Application of design of experiment approach for investigating the effect of partially…
The objective of the current work was to enhance the critical attributes of rapid orally disintegrating tablets (RODTs) manufactured by direct compression technique to have sufficient mechanical strength and fast disintegration time using…
Lipid nanocapsules decorated and loaded with cannabidiol as targeted prolonged release carriers for…
The therapeutic potential of cannabinoids has been truly constrained heretofore due to their strong psychoactive effects and their high lipophilicity. In this context, precisely due to the lack of psychoactive properties, cannabidiol (CBD),…
Gellan gum and polyvinylpyrrolidone (PVP) as binding agents in extrusion/spheronization pellet…
The aim of this work was to evaluate gellan gum as binder in pellet formulations, with theophylline as the model drug, in comparison with polyvinylpyrrolidone (PVP). A full 32 factorial design was realized, with binder and dilu- ent factors…
A combination of the advantages of film coating and sugar coating?
Sugar Coating – from conventional to continuously automated When it comes to aesthetics, shine and good insulation, traditional sugar-coated tablets are still a very popular dosage form. Among the numerous coating layers, the bad-tasting…
Hybrid modeling of roll compaction processes with the Styl’One Evolution
Roll compaction/dry granulation is a widely used and cost effective dry granulation method. To save time and material in formulation development, some approaches have been made to predict the most important parameters in roll compaction…
A Big Data Approach to Pharmaceutical Flow Properties
Flowability is a key consideration during the formulation and process development of oral solid dosage forms as it can have a critical impact on product quality. With a limited number of examples available in the literature, there is a need…
Printfills: 3D printed systems combining Fused Deposition Modeling and Injection Volume Filling.…
Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling (FDM)…
Pharmaceutical excipients, news from China
Chinese authorities pointed out a new roadmap on the quality of pharmaceutical excipients. The representatives of the Chinese Pharmacopoeia have talk about that last September 18th, during a workshop organised by Edqm.
In the last…
A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the…
Novel cellulose-gelatin composite films made from self-dispersed microgels: Structure and properties
A series of epichlorohydrin-couple-linked cellulose-gelatin composite films (ECGF) was fabricated in NaOH/urea aqueous solution using a process involving homogenous blending, coupling, dialysis, self-dispersion, microgel solution casting,…
Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating…
The oral cavity is of great importance to the performance of orally retained formulations, including: orally disintegrating tablets, taste-masked formulations, and buccal/sublingual delivery systems. With regards to in vitro dissolution…
Amorphous multi-system of celecoxib improves its anti-inflammatory activity in vitro and oral…
In the present study, a multi-system for solid dispersion (SD) of celecoxib (CXB) was designed to improve its solubility and anti-inflammatory effects in vitro as well as oral absorption in rats. The SD formulations were prepared by a…
Become part of pharmaexcipients – write in Excipient Basics!
Pharmaceutical excipients are an important part of any formulation and still we do not know enough about them. We therefore aim to improve the general knowledge on pharmaceutical excipients and have launched "Excipient Basics" on…
A comparison of drum granulation of biochars
Drum granulation can be used to form biochar granules that could reduce dust hazards during biochar application to soils. An investigation of the effect of operational parameters using three biochar feedstock was conducted to identify the…
FDA’s Woodcock: ‘The clinical trial system is broken
A BioPharma Dive article
The Food and Drug Administration's top drug regulator sharply criticized the current clinical trial regime, calling for industry to embrace more collaborative studies.
"I believe the clinical trial system is…
Testosterone- and vitamin-grafted cellulose ethers for sustained release of camptothecin
Camptothecin (CPT), a potent anticancer drug with known antiviral activity, is halted of clinical use. Few drug delivery systems of CPT are approved for therapy. Hereby, we propose the encapsulation of hydrophobic CPT in the inner core of…
Development of porous particles using dextran as an excipient for enhanced deep lung delivery of…
This study aimed to develop a dry powder inhaler (DPI) formulation for enhanced deep lung delivery of rifampicin using dextrans of different molecular weights. Porous particles were formed by a spray-drying method, which was designed based…
The Application of Machine Learning Algorithms in Understanding the Effect of Core/Shell Technique…
This study systemically investigated the application of core/shell technique to improve powder compactability. A 28-run Design-of-Experiment (DoE) was conducted to evaluate the effects of the type of core and shell materials and their…
Rapid and Fast-Release Acetaminophen Gelcaps Dissolve Slower Than Acetaminophen Tablets
The dissolution properties of oral medicinal drugs are affected by formulation and used to market over-the-counter medications. Acetaminophen is one of the most commonly used over-the-counter pain and fever-reducing medications with an…
Excellence in Lactose
In this video you learn more about Armor Pharma's Lactose production and solutions offered.
More on Armor Pharma
3D printing for chemical, pharmaceutical and biological applications
3D printing is becoming increasingly prevalent in modern chemistry laboratories. This technology provides chemists with the ability to design, prototype and print functional devices that integrate catalytic and/or analytical functionalities…
Nanocellulose: Insight into Health and Medical Applications
Discovering biomaterials of renewable and sustainable has become primary goal among researchers as a way to mitigate environmental impact. One of those abundantly present is cellulosic materials. Agricultural waste such as banana rachis,…
Powder bed 3D-printing of highly loaded drug delivery devices with hydroxypropyl cellulose as solid…
3D-printing is a promising tool to pave the way to the widespread adaption of individualized medicine. Several printing techniques have been investigated and introduced to pharmaceutical research. Until now, only one 3D-printed medicine is…