Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
Solid Oral Dose Process Validation
Currently there are no process validation (PV) textbooks addressing the lifecycle concepts (Stage 1, 2, 3). Recent regulatory guidance's such as US FDA, EMEA, WHO, PIC/S have adopted the ICH lifecycle approach. The concepts are now…
The Taste of 101 API’s summarized
It is widely recognized that many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. But bitterness is not the only challenge in creating palatable, patient-accepted drug products. If not bitter, what are other common…
Excipients for Direct Compression
Direct compression is not only a topic in continuous manufacturing but in pharmaceutical production in general. In direct compression the physical characteristics of the excipients have a major impact on the processes ability of the…
Annex to the European Commission guideline on ‘Excipients in the labelling and package leaflet…
This document is the Annex to the European Commission guideline on Excipients in the labelling and package leaflet of medicinal products for human use. It contains the information which should appear in the package leaflet for the…
Pediatric Oral Formulations: An Updated Review of Commercially Available Pediatric Oral Formulations…
Oral pediatric formulations are either ready-to-use or require manipulation, and multi-use or single-use. Strong encouragement for preservative-free pediatric formulations has resulted in fewer multi-use solutions or suspensions in favor of…
Direct compression tablet containing 99% active ingredient – a tale of spherical crystallization
Direct compression (DC) is the easiest and most cost-effective process for tablet manufacturing, since it only involves blending and compression. However, active pharmaceutical ingredients (API) generally exhibit poor mechanical and…
Pharmaceutical preformulation studies and paediatric oral formulations of sodium dichloroacetate
The purpose of this study was to develop liquid and solid paediatric formulations of sodium dichloroacetate (DCA) for the treatment of congenital lactic acidosis (CLA). In this work preformulation studies on the active molecule were…
Conversion of PLGA nanoparticle suspensions into solid dosage forms via fluid bed granulation and…
Incorporating poorly soluble drugs into polymeric nanoparticles is a widely investigated approach to improve their biopharmaceutical performance. Poly(DL-lactide-co-glycolide) (PLGA) nanoparticle formulations have previously been tested and…
3D and 4D Printing in Biomedical Applications: Process Engineering and Additive Manufacturing
A professional guide to 3D and 4D printing technology in the biomedical and pharmaceutical fields
3D and 4D Printing in Biomedical Applications offers an authoritative guide to 3D and 4D printing technology in the biomedical and…
Application of Flash Nanoprecipitation to Fabricate Poorly Water-soluble Drug Nanoparticles
Nanoparticles are considered to be a powerful approach for the delivery of poorly water-soluble drugs. One of the main challenges is developing an appropriate method for preparation of drug nanoparticles. As a simple, rapid and scalable…
Spray drying of pharmaceuticals and biopharmaceuticals: Critical parameters and experimental process…
Spray drying is increasingly becoming recognized as an efficient drying and formulation technique for pharmaceutical and biopharmaceutical processing. It offers significant economic and processing advantages compared to…
Excipients for Modified Release by Gattefossé
Modified- or sustained-release matrices are designed to release a drug slowly over an extended period of time. Formulations must be robust to ensure drug release over time and avoid dose-dumping. Lipid-based matrices are water-insoluble and…
Development of a Solid Supersaturated Self-Nanoemulsifying preconcentrate (S-superSNEP) of…
Recrystallization of drug and incomplete drug release from liquisolid formulation are two major hurdles in the development of a supersaturated self-nanoemulsifying drug delivery system. The aim of this research work was to develop a solid…
Rethinking carbamazepine oral delivery using polymer-lipid hybrid nanoparticles
Epilepsy is the most common chronic brain disorder and affects millions of people worldwide. Carbamazepine (CBZ) is one of the first-line pharmacological therapy instituted to patients due to its wide spectrum of action. Although marketed…
On-demand manufacturing of immediate release levetiracetam tablets using pressure-assisted…
Fast and accurate manufacturing of individually tailored solid dosage forms is one of the main challenges for personalized medicine. The use of 3D printers has recently been studied to determine their suitability for personalized drug…
Drug supersaturation during formulation digestion, including real-time analytical approaches
Self-emulsifying and other lipid-based drug delivery systems have drawn considerable interest from pharmaceutical scientists for managing oral delivery of poorly water-soluble compounds. Following administration, self-emulsifying systems…
Formulation of amlodipine nano lipid carriers
The present work was designed to formulate and statistically optimize transdermal amlodipine nanostructured lipid carriers (AMNLCs) using lipid blends. The formulation was optimized by using the independent variables Peceol (liquid lipid as…
Vote for the best Poster of the Pharmaexcipients Award!
The first online Poster Award is ready for voting! Check all the posters and give your votes to choose the winners!
Access all posters here
Which is the best of these posters with respect to attention attraction, coherent structure,…
API Taste Masking Challenges
It is widely recognized that many Active Pharmaceutical Ingredients (APIs) are bitter, some extremely so. But bitterness is not the only challenge in creating palatable, patient-accepted drug products. If not bitter, what are other common…
Influence of Poloxamer 188 on Design and Development of Second Generation PLGA Nanocrystals of…
The poly(D,L-lactide-co-glycolide) (PLGA) based second-generation nanocrystals prepared by modified nanoprecipitation method, is the method of choice for encapsulation of both lipophilic and hydrophilic drugs. In this study,…
Experimental and Modeling Study of Drug Release from HPMC-Based Erodible Oral Thin Films
In this work hydroxypropyl methylcellulose (HPMC) fast-dissolving thin films for oral administration are investigated. Furosemide (Class IV of the Biopharmaceutical Classification System) has been used as a model drug for in vitro release…
An Overview of 3D Printing Technologies for Soft Materials and Potential Opportunities for…
Three-dimensional printing (3DP) is a rapidly growing additive manufacturing process and it is predicted that the technology will transform the production of goods across numerous fields. In the pharmaceutical sector, 3DP has been used to…
Toxicological study of doxorubicin-loaded PLGA nanoparticles for the treatment of glioblastoma
Doxorubicin loaded in poloxamer 188-coated PLGA nanoparticles (Dox-NP + P188) was shown to produce a high antitumor effect against the experimental orthotopic 101.8 glioblastoma in rats upon intravenous administration. The objective of the…
Application of natural polymers as pharmaceutical excipients
The use of natural polymer as excipients in pharmaceutical sector is expanding day by day. Low cost, safety degradable are the main causes that make them differ from other sources. Natural sources have wide range…
Effects of Different Polymers on Thermal Inkjet Printing of Oral Thin Films: A Novel Approach
The aim of this research was to use inkjet printing technology in formulation of personalized medicine. Thus in this research, an attempt was made to print OTF by TIJ printing. A placebo solution comprising of different polymers and polymer…
Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based…
The absolute bioavailability of many small molecule kinase inhibitors (smKIs) is low. The reasons for low bioavailability are multifaceted and include constraints due to first pass metabolism and poor absorption. For smKIs where absorption…
Selection of the suitable polymer for supercritical fluid assisted preparation of carvedilol solid…
Solid dispersions production is one of the substantial approaches for improvement of poor drug solubility. Additionally, supercritical fluid assisted method for preparation of solid dispersions can offer many advantages in comparison to the…
Understanding the problems in pharmaceutical procurement with special reference to active…
Procurement of raw materials, key intermediates and excipients for the preparation of finished pharmaceutical preparation is considered to be complex process which involve multiple channels and require skilled personnel and proper…
Prolonged release from orodispersible films by incorporation of diclofenac-loaded micropellets
Prolonged drug release provided by multiple-unit dosage forms is highly beneficial to enhance the compliance and safety of the pharmacotherapy even for patients with swallowing deficiencies. To facilitate the intake for these patients,…
Successful development of oral SEDDS: Screening of excipients from the industrial point of view
Oral administration is the most accepted and favored route as various side effects such as fear, pain and risk of infections can be avoided resulting in a comparatively high patient compliance. However, from the industrial point of view the…
Quality Documents of Raw Material Manufacturers – A New Efficient & Controlled Way of…
As a pharmaceutical raw material producer, sending several high-level quality statements and certificates daily is an essential part of the sales process. What if there were a simpler way? What if a secure, digital platform could enable you…
Fully customizable Lactose by Armor Pharma
“How would you like your lactose?” is the first question Armor Pharma will ask you.
Armor Pharma's commitment is to listen to customer’s needs, to strive to achieve the same goals and to provide suitable solutions.
An especially…
Enzyme Immobilisation on Mesoporous Silica, Inspired by Chaperonins
In nature, chaperonins stabilise enzymes and protect them from high temperature and unfavourable solution conditions. We are inspired by some of chaperonins’ fundamental properties when investigating materials for enzyme immobilisation. In…