Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
The EU and APIs: Changing the Rules of the Game in Manufacturing
Innovator and generic-drug companies are squaring off on a proposal by the European Commission (EC) for an export manufacturing waiver for supplementary protection certificates (SPCs) in the European Union (EU). What are the implications…
Lipid Nanoparticles and Their Hydrogel Composites for Drug Delivery: A Review
Several drug delivery systems already exist for the encapsulation and subsequent release of lipophilic drugs that are well described in the scientific literature. Among these, lipid nanoparticles (LNP) have specifically come up for dermal,…
Development and stability of an oral suspension of procarbazine in pediatrics
Many drugs used in pediatric oncology are not labeled and adapted for pediatric use, such as caps of procarbazine to treat gliomas in children under 6 years old. Indeed, pediatric patients present difficulties to swallow these caps and it…
Relationship between amorphous solid dispersion In Vivo absorption and In Vitro dissolution
Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to evaluate amorphous formulations in vitro and in vivo.…
Design of antiretroviral drug-polymeric nanoparticles laden buccal films for chronic HIV therapy in…
Anti-HIV drug Lamivudine exhibit shorter half-life (2 h) and poor bioavailability (62% in paediatric patients), multiple dosing is required. To overcome the limitations, nanoparticles loaded buccal film was developed for prolonged drug…
Variability in the α and β anomer content of commercially available lactose
Lactose, a disaccharide is a ubiquitous excipient in many pharmaceutical formulations which exists in two anomeric forms; either as α- or β-lactose. The anomers have different properties which can affect their application. Nevertheless,…
Novel dry particle coating technique to achieve modified release properties using QbD
Quality by Design (QbD), a current trend employed to develop and optimise various critical pharmaceutical processes, is a systematic approach based on the ethos that quality should be designed into the product itself, not just end tested…
Guar gum: Versatile natural polymer for drug delivery applications
Guar gum a non-ionic polysaccharide obtained from the seeds of Cyamopsis tetragonolobus of the Leguminosae family is found abundantly in nature. It finds extensive use in a variety of fields such as food industry, textile industry, paper…
Congratulations to Dave Schonecker for the IPEC lifetime Award!
We also like to thank and congratulate Dave Schoneker, Director of Global Regulatory Affairs at Colorcon, for the Outstanding Lifetime Achievement award at last night’s IPEC awards. He was recognized for Substantial Intellectual…
Role of Excipients in Amorphous Solid Dispersions – Video Explanation by BASF
Dr. Frank Romanski speaks about the the role of excipient selection and key characteristics in amorphous solid dispersions at the BASF Solubilization Symposium in Ludwigshafen, Germany.
Smallest continuous wet granulation line for process development at AAPS
Meet the experts from Glatt at AAPS 2018 in Washington DC at booth 1109 and learn more about the MODCOS XS-line, the smallest continuous wet granulation line for process development.
Granulation techniques and technologies: recent progresses
Granulation, the process of particle enlargement by agglomeration technique, is one of the most significant unit operations in the production of pharmaceutical dosage forms, mostly tablets and capsules. Granulation process transforms fine…
Inhibitory Effects of Commonly Used Excipients on P-Glycoprotein in Vitro
Pharmaceutical excipients are no longer considered inert and have been shown to influence the activity of metabolic enzymes and transporters, resulting in altered pharmacokinetics of substrate drugs. In this study, the effect of 25…
A Novel Complex of Chitosan–Sodium Carbonate and Its Properties
Chitosan has excellent properties, as it is nontoxic, mucoadhesive, biocompatible, and biodegradable. However, the poor water solubility of chitosan is a major disadvantage. Here, a novel chitosan-sodium carbonate complex was formed by…
Efficient Mucosal Immunization by Mucoadhesive and pH-Sensitive Polymeric Vaccine Delivery System
Mucosal surfaces as the largest immune organ of human body cover 400 m2 of the body including the gastrointestinal, urogenital, and respiratory tracts. The local mucosal immunity is an important first line of defense against many pathogens…
A Statistical Determination of the Contribution of Viscoelasticity of Aqueous Carbohydrate Polymer…
In this study the relationship between the viscoelasticity/mechanical properties of metronidazole-containing aqueous polymer networks composed of HEC and PVP and drug release was statistically modelled. The networks were characterised using…
Pharma Excipient Poster Award – Video
This Video explains more about the Pharma Excipients Poster Award - how you can see the Posters and read the Abstracts.
Direct Link to Posters of the Pharma Excipients Poster Award
Pharmaceutical applications of 3D printing technology: current understanding and future perspectives
Three-dimensional printing (3DP) technology allows the fabrication of 3D objects with various geometrics in a layer-by-layer process. Some advantages of 3DP methods over the conventional manufacturing processes include the customization of…
Pharma Excipients Poster Award – Posters are online!
Check out the posters submitted for the Award here. The votings will be opened soon!
Here some examples - click on one to see them all!
Sigachi receives Company of the year – Pharmaceuticals Award
Sigachi announced the receipt of “Company of the year - Pharmaceutical in Zee Business Dare to Dream Award”. The award is under the SME category and is given to companies and entrepreneurs, who excel in their respective…
Novel Excipients and Regulations in China
IPEC-Americas presents 2 Rapid Fire Sessions at AAPS:
Joe Zeleznik and Priscilla Zawislak will talk about Novel Excipients and Regulations in China
More Information
Inside the Phenomenological Aspects of Wet Granulation: Role of Process Parameters
Abstract Granulation is a size-enlargement process by which small particles are bonded, by means of various techniques, in coherent and stable masses (granules), in which the original particles are still identifiable. In wet granulation…
Hot-melt extruded lipidic pellets for pediatric applications: An investigation of the effects and…
The current study investigates the development of extemporaneous preparation of hot melt extruded diclofenac sodium (Df-Na) pellets processed with glyceryl dibehenate (Compritol® 888 ATO) and dibasic calcium phosphate anhydrous (Fujicalin®)…
Biorelevant in vitro assessment of dissolution and compatibility properties of a novel paediatric…
Alkindi® is a novel oral multi-particulate taste-masked formulation of hydrocortisone for use in children with the rare disease adrenal insufficiency. The objective of the present work was to study the biorelevant dissolution…
Relative Sweetness: How Sweet Is Sweet?
Broadly speaking, there are three categories of sweeteners – nutritive, sugar alcohols, and high intensity. Sweetener selection is informed by technical, regulatory and clinical considerations as described in the Introduction to Sweeteners.…
An introduction to pharmaceutical film coatings
A wide variety of pharmaceutical products, including pellets, granules, capsules, powders, and crystals are often film coated. In this present article, we will concentrate on the film-coating of tablets.
The procedure of coating tablets…
Development of high drug loaded pellets by Design of Experiment and population balance model…
Medicines of drug coated inert pellets filled into hard capsules or compressed into tablets are already on the market, until now, their number is limited and there are few systematic investigations of possible coating amounts. Pellets of…
Comparison between Microcrystalline Celluloses of different grades made by four manufacturers using…
The characterization of pharmaceutical powders by means of the SeDeM diagram expert system allows developing a database. This database is a useful tool in pre-formulation steps as initial screening for suitable filler excipients. This study…
A platform direct compression formulation for low dose sustained-release tablets enabled by a dual…
Content uniformity (CU) is a well-recognized challenge for low-dose direct compression (DC) tablet formulations. Using a dual particle engineering approach that involves a) forming a segregation-resistant drug-carrier composite to improve…
Water-soluble and -insoluble polymers as binders for pellet preparation by extrusion/spheronization
The objective of this study was to investigate the effect of binder (water-soluble vs. -insoluble) and granulation fluid (aqueous vs. organic) on the physical properties of pellet prepared by extrusion/spheronization and on drug release.…
In vitro lipolysis test in lipid-based formulation development
The lipolysis test is recommended during lipid-based formulation (LBF) development to evaluate whether the prototype formulations should be able to solubilize and maintain the drug in solution during the ‘in vivo’ digestion process. It is…
Nanoamorphous drug products – Design and development
Most of the recent drug compounds coming out of the drug discovery pipeline are labile (multiple polymorphs), and need to be developed into robust marketed oral drug formulations. There are only 22 oral macroamorphous drug products approved…
Preparation of a solid self-microemulsifying drug delivery system by hot-melt extrusion
Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare…
The wall friction properties of pharmaceutical powders, blends and granulations
Data from wall friction testing and physical property characterization of over one hundred pharmaceutical powders, blends, and granulations has been analyzed. The analyses focused on data for stainless steel surfaces with the most common…