Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
The impact of digestion is essential to the understanding of milk as a drug delivery system for…
Milk has previously been considered as a potential lipid-based drug delivery system for poorly water soluble drugs but it has never gained significant attention. This is in part because relying on solubility in lipid-based formulations (in…
Design of a new disintegration test system for the evaluation of orally disintegrating films
In the design of the orally disintegrating films (ODFs), it is important to determine the disintegration time (DT) precisely and properly. These films’ DTs are usually assessed by a disintegration test defined in the pharmacopoeias, but…
High shear blending with glyceryl distearate provides individually coated drug particles for…
Lipid coating in a high shear blender without heating and complex spray mechanism was investigated as a simplified approach to hot melt coating in a fluid bed device. Potassium chloride was coated with 20% glyceryl distearate using both…
Study on Swallowability of EUDRAGIT® Coated Tablets
A swallowing disorder, known as dysphagia, is a phenomenon of increasing prevalence. It may occur because of various medical conditions involving the oral cavity, the pharynx, the esophagus, and the gastro-esophageal junction. The US FDA…
Interested why Kollidon® 12 PF / Kollidon® 17 PF are particularly suitable for parenteral…
Did you know that Kollidon® 12 PF and Kollidon® 17 PF are highly suitable for injectable formulations?
Kollidon® 12 PF/ Kollidon® 17 PF low molecular weight make them particularly suitable for parenteral
applications. Additionally, they are…
Top Pharma & Biotech Deals, Investments, M&As in September 2018
As compared to the previous months, September was a slower month for dealmaking. The Wall Street Journal recently attributed the drought in big biotech deals to the riskiness of the business. In a note to clients, a Jefferies health care…
Designing pH-Responsive Biodegradable Polymer Coatings for Controlled Drug Release via Vapor-Based…
We present the design of a novel pH-responsive drug release system that is achieved by solventless encapsulation of drugs within a microporous membrane using a thin capping layer of biodegradable polymethacrylic anhydride (PMAH) coating.…
Novel population balance model for granule aggregation and breakage in fluidized bed granulation and…
A novel population balance model for the fluidized bed granulation and drying process was developed taking into consideration moisture content for determining the coalescence and breakage probabilities. Experimental data of pharmaceutical…
Pharmacodynamical Effects of Orally Administered Exenatide Nanoparticles Embedded in…
One of the major disadvantages associated with macromolecules therapy is that most of them can only be administered parenterally. Exenatide, an efficient anti-diabetic drug, incretin mimetic, is currently administered subcutaneously (SC)…
Gas adsorption on commercial magnesium stearate: The origin of atypical isotherms and BET transform…
The causes of atypical nitrogen adsorption isotherm features of commercial magnesium stearate grades have been investigated through a combination of alternative adsorbates and variation of analytical conditions. Atypical features have…
Creating Value with Tailored ODT Solutions
Increasing patient adherence to medication regimens remains a top priority in the pharmaceutical industry. Simultaneously, consumers/patients are looking for dosage forms that are easy to take and that will not disrupt their everyday “on…
mceODT all-in-one directly compressible excipient – video
mceODT is highly effective semi-natural multicomponent, multifunctional co-processed excipient, designed for orally disintegrating tablets and chewable produced by method of direct compression. It is a homogenous mixture composed of filler…
Optical coherence tomography as a novel tool for in-line monitoring of a pharmaceutical film-coating…
Optical coherence tomography (OCT) is a contact-free non-destructive high-resolution imaging technique based on low-coherence interferometry. This study investigates the application of spectral-domain OCT as an in-line quality control tool…
Introduction to pharmaceutical excipients – a video
In this video Chris Moreton gives an interesting insight on pharmaceutical excipients.
Considering 3D Printing for Solid Dosage Forms
Three-dimensional printing (3DP) is also known as additive manufacturing because these technologies create a part by adding material layer by layer, guided by a 3D computer model. Various types of 3DP are being used in manufacturing in…
2019 IPEC Europe Annual Excipients Forum
Thursday 31 January 2019
The Westin Dragonara, St Julian's, Malta
The theme of the 2019 Forum is "Excipient Integrity". The programme will cover many ‘hot’ topics including best practices and insights that can help your company adapt…
Just a spoonful of… makes the medicine go down.
galenIQ™ is a soluble filler-binder characterized by its ease of use and applicability to a wide range of solid and liquid medicine such as tablets, sachets, lozenges and syrups. The main reason it works is its delicate sweetness. Read more…
Rheology of Cellulose Ether Excipients Designed for Hot Melt Extrusion
new family of cellulosic ether polymeric excipients has been recently engineered for fabrication of amorphous solid dispersions (ASDs) of active pharmaceutical ingredients (API) via hot-melt extrusion (HME). These hydroxypropyl methyl…
22nd Microencapsulation Industrial Convention
The Bioencapsulation Research Group organizes the 22nd Microencapsulation Industrial Convention
June 3-6, 2019 in Zurich, Switzerland
13 Presentations from experts
Lectures from leading experts will cover a large scope of the…
Dissolution improvement of an active pharmaceutical ingredient in a polymer melt by hot melt…
Dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in polymeric melts plays an important role in the manufacturing of solid dispersions and solid solutions. The understanding of the dissolution is essential for…
FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with…
A compatibility study of drug substance with excipients is a crucial step in the drug development process in order to generate potent final drug formulations for efficient and safe therapy for various diseases. Thus, the development of new…
The Importance of Excipient Composition and Complexity
Tuesday, November 13, 2018 - 11:00am
This webinar presented by Chris Moreton and Brian Carlin will provide an overview of excipient composition and complexity. In this Quality by Design age and the need for enhanced understanding,…
Oxygen sensitive nanoparticles used for 3D printing of complex tissue-like structures
Researchers have implemented oxygen sensitive nanoparticles into a gel material that can be used for 3D printing of complex, biofilm and tissue-like structures…
An international team of researchers have implemented oxygen sensitive…
SeDeM expert system for directly compressed tablet formulation: A review and new perspectives
The pharmaceutical tablet formulation design is a risky and challenging process since it largely depends on experience. The fundamental reasons lie in the lack of understanding of powder properties and the interactions between the active…
Quality Deviation Handling on the Polymeric Coating of Pharmaceutical Tablets
This work aimed to map and discuss tablet-coating choice, quality deviations of this process, and corrective actions taken by Research and Development (R&D) teams from pharmaceutical industries.
Methods
A cross-sectional study of…
A study of the impact of excipient shielding on initial drug release using UV imaging
Knowledge on the dissolution behaviour of a drug is critical for efficient and effective product development. As the drug has almost always to be formulated with excipients in the design of a dosage form, it is important to examine the…
Calibration-free in-line monitoring of pellet coating processes via optical coherence tomography
The paper presents a new in-line measurement technique for determining the coating thickness and uniformity of pharmaceutical pellets during film-coating in a fluid-bed apparatus. Non-destructive and contact-free process monitoring was…
Lecithin–chitosan–TPGS nanoparticles as nanocarriers of (−)-epicatechin enhanced its anticancer…
Natural compounds such as (−)-epicatechin show a variety of biological properties including anticancer activity. Nonetheless, (−)-epicatechin's therapeutic application is limited due to its low water solubility and sensitivity to oxygen and…
EXCIPIENT AND PROCESS SELECTION FOR EXTRUSION TECHNOLOGIES
Webinar October 25, 2018 by by The Southern California Pharmaceutical Discussion Group (SCPDG) of AAPS
Registration: Please register by Monday, October 22, 2018 using link below:
SCPDG - Rational Excipient Selection and Incorporation of…
The rise of independent excipients
The pressure to innovate faster than their competitors has drug formulators exploring new ways to optimise manufacturing processes
Article in manufacturingchemist.com
Continuous manufacturing, for example, has evolved at a relatively fast…
Soluplus solutions as thermothickening materials for topical drug delivery.
Soluplus is a pharmaceutical excipient used primarily in the manufacture of solid dispersions. The polymer also exhibits interesting rheology in aqueous solution, increasing in viscosity as the solution is warmed. This material could have…
Review Oral Modied Release Multiple-Unit Particulate Systems: Compressed Pellets, Microparticles and…
Oral modied-release multiparticulate dosage forms, which are also referred to as oral multiple-unit particulate systems, are becoming increasingly popular for oral drug delivery applications. The compaction of polymer-coated…
Chitosan-Based In Situ Gels for Ocular Delivery of Therapeutics: A State-of-the-Art Review
Ocular in situ gels are a promising alternative to overcome drawbacks of conventional eye drops because they associate the advantages of solutions such as accuracy and reproducibility of dosing, or ease of administration with prolonged…
Physical and rheological properties of xanthan gum agglomerated in fluidized bed: Effect of HPMC as…
Physical and rheological properties of agglomerated xanthan gum (XG), commonly used as a food thickener for the management of the patients with dysphagia (swallowing difficulty), were investigated at different concentrations (0, 2, 4, and…