Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
FORMULATION OF SNAIL SLIME (Achatina fulica) ANTI-ACNE EMULGEL USING TWEEN 80-SPAN 80 AS EMULSIFYING…
ABSTRACT
Acne is the condition of abnormal skin which is indicated by inflammation cause by the bacterial infection of Propionibacterium acnes. The natural one which can be used for the medical treatment of acne is the snail mucus…
Impact of capsule type on aerodynamic performance of inhalation products: a case study using a…
The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the…
Roller compaction: Improving the homogeneity of ribbon properties along the roller width
A new roller with a novel surface geometry was designed and used in this study in order to improve the uniformity of the stress distribution along the roller width. This was aimed to produce homogenous properties across ribbon width. The…
Analysis of the powder behavior and the residence time distribution within a production scale rotary…
This study focuses on the behavior of powder particles in a rotary tablet press with special focus on the feed frame system. To obtain a better knowledge of the continuous manufacturing of tablets, the experimental setup was carried out…
Impact of polymers on the aggregation of wet-milled itraconazole particles and their dissolution…
We explore the impact of various polymers and their molecular weight on the stabilization of wet-milled suspensions of itraconazole (ITZ), a poorly soluble drug, and its dissolution from spray-dried suspensions. To this end, ITZ suspensions…
Dropwise Additive Manufacturing of Pharmaceutical Products using Particle Suspensions
The principal method of drug delivery is by oral solid doses, the production of which often necessitates multiple post-crystallization unit operations to ensure content uniformity and/or enhance bioavailability. As an alternative to…
Evaluation of the application of cashew gum as an excipient to produce tablets
Cashew gum is extracted from the exudate of the giant cashew tree (Anacardium occidentale L.). The objective of this work was to study the extraction and purification of cashew gum through experiments to characterize its structures and…
Methodology to estimate the break force of pharmaceutical tablets with curved faces under…
This paper develops a methodology to estimate the break force of curved faced tablets under diametrical compression. Common excipients used in pharmaceutical tablet formulations, including microcrystalline cellulose, calcium phosphate and…
Pollen grains as a novel microcarrier for oral delivery of proteins
Oral delivery of proteins and peptides is a challenge due to their degradation in the stomach. To overcome this challenge, ragweed (Ambrosia elatior) pollen grains were engineered to serve as protective microcapsules. A matrix comprising of…
Pharmacokinetic Properties of Acetyl Tributyl Citrate, a Pharmaceutical Excipient
Acetyl tributyl citrate (ATBC) is an (the Food and Drug Administration) FDA-approved substance for use as a pharmaceutical excipient. It is used in pharmaceutical coating of solid oral dosage forms such as coated tablets or capsules.…
Towards a better understanding of dry binder functionality
It is of great importance to get a deeper understanding of the binding behaviour and functionality of different types of dry binders, since dry binders are crucial to ensure appropriate properties of dry granules and tablets. Based on…
Pharmaceutical applications of spouted beds: A review on solid dosage forms
Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing…
Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate…
Co‐encapsulation of abiraterone acetate (AbrA) and docetaxel (Dtx) in polymeric nanoparticles as novel prototypes for prostate cancer treatment combining hormonal and chemotherapy was designed. Nanoparticles (NPs) composed of…
Use of Mannitol as a Filler in Wet Granulation
A study was conducted to evaluate mannitol as a filler along with microcrystalline cellulose (MCC) in wet granulated tablet formulation, in situations in which lactose cannot be included in the formulation because of chemical…
Simplified end-to-end continuous manufacturing by feeding API suspensions in twin-screw wet…
This study focussed on investigating the coupling of continuous manufacturing of drug substance and continuous manufacture of drug product. An important step in such an integrated end-to-end continuous manufacturing was envisioned by dosing…
Cellulose-Based Composite Hydrogels: Preparation, Structures, and Applications
In this chapter, cellulose-based composite hydrogels were summarized in three categories according to the components. Synthetic polymer/cellulose composite hydrogels combine the advantages of synthetic polymers and cellulose. Soluble…
PharSQ Spheres – Calcium Phospate Starter Pellets
Drug layering on starter pellets is a standard technology to achieve multiparticulate dosage forms. The most widely used are still sugar spheres / non-pareils but also neutral pellets made of microcrystalline cellulose such as Cellets are…
Merck wins CPhI Award with Parteck® MXP for Excellence in Pharmaceutical Excipients
We congratulate Merck for winning the Award with Parteck® MXP excipient for hot melt extrusion. Here some information on the product:
Enhanced API Solubility and Stable, High Drug LoadsPoor solubility of APIs is a critical challenge in drug…
Effect of Binder Attributes on Granule Growth and Densification
The rate and extent of granule growth and densification during high-shear wet granulation (HSWG) depends on a variety of formulation and process variables, including material attributes of critical formulation excipients, such as binders.…
Effect of absorption-modifying excipients, hypotonicity, and enteric neural activity in an in vivo…
The small intestine mucosal barrier is physiologically regulated by the luminal conditions, where intestinal factors, such as diet and luminal tonicity, can affect mucosal permeability. The intestinal barrier may also be affected by…
Orally disintegrating dosage forms
What is an orally disintegrating dosage form?
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way…
Orally disintegrating dosage forms
An orally disintegrating tablet is a novel formulation that dissolves in the saliva within a few seconds and without requiring of drinking additional water. This dosage form is a powerful way to deliver active drugs ingredients because it…
Enhanced supersaturation of chlortetracycline hydrochloride by amorphous solid dispersion
Chlortetracycline hydrochloride (CTC) has been reported as having low aqueous solubility, leading to a limitation in its administration in treatments. This study demonstrated a strategy to enhance the supersaturated solubility of CTC by…
An investigation into the release behavior of solid lipid microparticles in different simulated…
In recent years there has been a growing interest in solid lipid-based systems, particularly in solid lipid microparticles (SLMs); however, only very few studies deeply investigated the dissolution behaviour of orally delivered-SLMs. The…
Fabrication of naftopidil-loaded tablets using a semi-solid extrusion-type 3D printer, and the…
The production of 3D-printed drugs holds promise for future personalized medicine. Here, we prepared tablets containing naftopidil as a model drug using a semi-solid extrusion-type 3D bioprinter applicable for tissue engineering. A hydrogel…
Conformational polymorphic changes in the crystal structure of the chiral antiparasitic drug…
Praziquantel is an antiparasitic drug used for decades. Currently, the praziquantel commercial preparation is a racemic mixture, inwhich only the levo-enantiomer possesses anthelmintic activity. The knowledge of its properties in the solid…
Paliperidone ascending controlled-release pellets with osmotic core and driven by delayed osmotic…
The aim of this work was to develop an ascending controlled-release pellet (ACRP) of paliperidone to improve poor solubility and provide a stable blood drug concentration. The inner core was produced by mixing different ratios of sodium …
The influence of polymer excipients on the dissolution and recrystallization behavior of…
The formulation of amorphous solid dispersions (ASDs) is an effective way to improve the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs). The combination of an amorphous state of the drug and the presence of…
Controlled release of caffeine from tablets of spray-dried casein gels
The controlled release of caffeine from the casein gel tablets has been achieved over release periods lasting from a few minutes to over a few days. A novel casein gel has been acidified at pH of 1.0 as the insoluble controlled-release…
Continuous twin screw wet granulation: The combined effect of process parameters on residence time,…
In this study, a set of 24 experiments was designed to understand the combined effect of different process parameters, i.e. material feed rate, liquid-to-solid (L/S) ratio, screw speed, and screw configuration on the residence time…
Commentary: New perspectives on protein aggregation during Biopharmaceutical development
The occurrence of protein aggregation during bioprocessing steps such as purification, formulation and fill-finish, impacts yield and production costs, and must be controlled throughout themanufacturing process. Understanding aggregation…
Lipid-Based Oral Formulation Strategies for Lipophilic Drugs
Partition coefficient (log P) is a key physicochemical characteristic of lipophilic drugs which plays a significant role in formulation development for oral administration. Lipid-based formulation strategies can increase lymphatic transport…
Influence of Ar plasma treatment on the wetting behavior of pharmaceutical powders
In this study, corn starch and ibuprofen are treated in Argon (Ar) plasma to enhance the wettability of the powders without using any additive or guest particle. The powder and pellets were exposed to the Ar plasma for different time…
Novel Combination Proliposomes Containing Tobramycin and Clarithromycin Effective against…
Tobramycin (TOB) and clarithromycin (CLA) can potentially be used synergistically for the treatment of respiratory infections caused by Pseudomonas aeruginosa (P. aeruginosa) in cystic fibrosis (CF) patients. This study aimed to develop a…