Dynamic phase behavior of amorphous solid dispersions revealed with in situ stimulated Raman scattering microscopy
This study reports the application of in situ stimulated Raman scattering (SRS) microscopy for real-time chemically-specific imaging of dynamic phase phenomena in amorphous solid dispersions (ASD). Using binary ritonavir and poly(vinylpyrrolidone-vinyl acetate) films with different drug loadings (0-100% w/w) as model systems, we employed SRS…
Engineering of pharmaceutical cocrystals in an excipient matrix: spray drying versus hot melt…
The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals within a carrier…
1st pharmaexcipients Poster Award – Final Deadline!
The final deadline is October 15, 2018!
Submit your posters now - see instructions here
Only abstracts / posters from 2017 onwards will be accepted. They can already have been presented at an event. Please ensure that you are allowed…
The Utilization of Propylene Glycol as a Pharmaceutical Excipient in the Pediatric Field
As a widely used excipient in pediatric formulations, propylene glycol functions as a solvent, emulsifier, humectant, and hygroscopic agent. It is a clear, colorless liquid whose properties enable it to have pharmacodynamic applications.…
Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery
The growing interest on polymeric delivery systems for pulmonary administration of drugs anticipates a more direct and efficient treatment of diseases such as tuberculosis (TB) that uses the pulmonary route as the natural route of…
Crystal anisotropy explains structure-mechanics impact on tableting performance of flufenamic acid…
Anisotropic features with other crystallographic properties like d-spacing,and attachment energy (Eatt) can predict material performance during the secondary pharmaceutical processing. A newly developed state-of-the-art compression cell…
Top Pharma & Biotech Deals, Investments, M&As in August 2018
16. September 2018
In August, the biotech boom of 2018 continued unabated and the Wall Street Journal reported that investment banks have lured top biotech analysts with guaranteed pay packages of USD 3 million or more.
At this time of…
Polyvinylpyrrolidone affects thermal stability of drugs in solid dispersions
15. September 2018
The present study explores the hypothesis that a polymer can affect the thermal stability of a drug in solid polymer-drug dispersions. The hypothesis is tested in a systematic fashion by combining isoconversional…
Challenges and innovations of drug delivery in older age
15. September 2018
Both drug delivery performance and various age-related physical, mental and physiological changes can affect their effectiveness and safety in elderly patients. The many drug delivery systems developed over the years…
Personalized orodispersible films by hot melt ram extrusion 3D printing
13. September 2018
This work demonstrates the feasibility of the extemporaneous preparation of maltodextrins orodispersible films (ODF) by hot-melt ram-extrusion 3D printing. This method consists of three simple technological operations…
Comparative study on disintegration methods for oral film preparations
13. September 2018
Orodispersible films (ODFs) provide high application comfort due to rapid disintegration in the oral cavity. They increasingly found the approval of pharmaceutical research and development and were added to the…
Effect of excipients on encapsulation and release of insulin from spray-dried solid lipid…
13. September 2018
The study aimed at investigating the potential of spray drying method for encapsulation of protein drugs into solid lipid microparticles (MP) and evaluating effects of excipients on encapsulation and release of protein…
Novel Co-processing Methodology to Enable Direct Compression of a Poorly Compressible Highly…
13. September 2018
Herein we introduce an innovative process for preparation of directly compressible API and excipient agglomerates for extended release formulation of a highly water soluble drug, demonstrated with metformin HCl.…
Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based…
12. September 2018
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-soluble drugs, however, development of solid dosage forms with ASD is challenging due to the high propensity of amorphous drug to…
A novel test system for the evaluation of oral mucoadhesion of fast disintegrating tablets
11. September 2018
Oromucosal drug delivery is necessary when a local effect in the oral cavity is required. Bioadhesive formulations should be advantageous because a larger fraction of the active principal is retained at the site of…
Main functionalities of lipid excipients for rectal/vaginal drug delivery
A very informative overview by Gattefossé on its excipients and uses thereof.
Lipid excipients for suppository and pessary formulation include hard fat and hard fat with additives. These bases provide excellent physico-chemical stability…
Particle engineering of needle shaped crystals by wet milling and temperature cycling: Optimisation…
16. August 2018
The purpose of this work is to demonstrate a process for the alteration of the shape of needle shaped crystals of an active pharmaceutical ingredient (API) using a combination of wet milling and temperature cycling. The…
Polymer Gels in Vaginal Drug Delivery Systems
16. August 2018
Vaginal drug delivery is a promising route for the treatment and prevention of local and systemic diseases such as genital herpes or AIDS. Suitable excipients must be selected to optimize the…
The influence of different acquisition settings and the focus adjustment on Raman spectral maps of…
15. August 2018
Pharmaceutical tablets contain a variety of active substances and excipients which could be monitored by Raman spectroscopy/microscopy. Raman microscopic spectra are affected not only by the sample…
Electrospun fixed dose formulations of amlodipine besylate and valsartan
15. August 2018
Increasing numbers of elderly people require multi-drug therapies. One route to improve adherence rates is to prepare fixed dose combinations (FDCs), in which multiple active ingredients are loadedinto a single…
Excipients in Neonatal Medicinal Products: Never Prescribed, Commonly Administered
15. August 2018 To attain effective and safe pharmacotherapy, formulations in (pre)term neonates should enable extensive dose flexibility. During product development and…
Aerosolized Surfactants: Formulation Development and Evaluation of Aerosol Drug Delivery to the…
15. August 2018
The overall aim of this research project was to develop surfactant dry powder formulations and devices for efficient delivery of aerosol formulations to infants using the excipient enhanced…
Setting Specifications for Excipients – Stimuli Article & Survey
14. August 2018
Setting Specifications for Excipients - Stimuli Article & Survey
A USP Stimuli article to the revision process, titled, “The Complexity of Setting Specifications for Excipient Composition and…
Single-chain polymer nanoparticles in controlled drug delivery and targeted imaging
14. August 2018
As a relatively new class of materials, single-chain polymer nanoparticles (SCNPs) just entered the field of (biomedical) applications, with recent advances in polymer science enabling the…
Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as…
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Abstract Study on the in situ aggregation of liposomes with negatively charged phospholipids for use as injectable depot formulation
Liquid Fill of Hard Gel Capsules – Investigating the Effect of Matrix-Excipients on the Release…
Full Abstract as PDF:
Poster_Liquid Fill of Hard Gel Capsules - Investigating the Effect of Matrix Excipients on the Release Characteristics_PosterAward
Unravelling liver ischaemia/reperfusion injury by using nanosystems to visualize and treat lesions
Full abstract as PDF:
Unravelling liver ischaemia reperfusion injury by using nanosystems to visualize and treat lesions
Miscibility of Glycerol Diether Bolalipids with Phospholipids for the Application as Oral Drug…
Abstract as PDF:
Abstract_S.Müller_Miscibility of Glycerol Diether Bolalipids with Phospholipids for the Application as Oral Drug Delivery Systems
Mapping the literature to better understand how excipients may affect biopharmaceutics aspects of…
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Mapping the literature to better understand how excipients may affect biopharmaceutics aspects of paediatric drug products permeability as a case example pe
SOLUTHIN® MD H: A FAST-DISPERSIBLE HYDROGENATED PHOSPHOLIPID FORMULATION INCREASING THE DISSOLUTION…
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Abstract_LIPOID_SOLUTHIN_MD_H_Solubilization
Using different coating technologies to apply a Kollicoat® Smartseal 30 based functional coat onto…
Full PDF Abstract
PDF_Abstract Poster_Pellet coating different equipment_PosterAward
Crystallization kinetics in amorphous solid dispersions can be quantified by water sorption…
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Crystallization kinetics in amorphous solid dispersions
Spray Dried Multiparticles of Chitosan Isolated from Marine Bio-species P. sanguinolentus for Food…
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Abstract Spray Dried Multiparticles of Chitosan Isolated from Marine Bio-species
Antagonist G-Labeled Long Circulating Liposomes Actively Targeted to Lung Tumor Cells
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Abstract Antagonist G-Labeled Long Circulating Liposomes Actively Targeted to Lung Tumor Cells