Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route
Despite the fact that several rheumatoid arthritis treatments have been utilized, none of them achieved complete joint healing and has been accompanied by several side effects that compromise patient compliance. This study aims to provide an effective safe RA treatment with minimum side effects through the encapsulation of melatonin (MEL) in…
Supercritical fluid technology as a strategy for nifedipine solid dispersions formulation: in vitro…
Abstract
Supercritical fluid technology (SFT) is an insufficiently investigated approach for the production of solid dispersions, it is environmentally acceptable and has a high potential for application in the pharmaceutical industry. The…
Co-processed materials testing as excipients to produce Orally Disintegrating Tablets (ODT) using…
The use of co-processed materials for Orally Disintegrating Tablets (ODT) preparation by direct compression is well consolidated. However, the evaluation of their potential for ODT preparation by 3D printing technology remains almost…
Development of famotidine-loaded lecithin-chitosan nanoparticles for prolonged and efficient…
Lecithin-chitosan nanoparticles (LCNPs) represent an appealing nanocarrier for the oral delivery of hydrophobic drugs. Negatively charged lecithin and positively charged chitosan were permitted to interact to create LCNPs. Their…
Physicochemical reports of gliclazide-carplex solid dispersions and tablets prepared with directly…
Abstract
Objectives
The main goal of this research was to develop better tablet formulations by utilizing solid dispersions (SDs) and coprocessing excipients composite to achieve a better release rate of poor water-soluble gliclazide.…
Phase homogeneity in ternary amorphous solid dispersions and its impact on solubility, dissolution…
Abstract
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution…
Visualizing disintegration of 3D printed tablets in humans using MRI and comparison with in vitro…
Three-dimensional (3D) printing is revolutionising the way that medicines are manufactured today, paving the way towards more personalised medicine. However, there is limited in vivo data on 3D printed dosage forms, and no studies to date…
3D bioprinting of multifunctional alginate dialdehyde (ADA)–gelatin (GEL) (ADA-GEL) hydrogels…
The present work explores the 3D extrusion printing of ferulic acid (FA)-containing alginate dialdehyde (ADA)–gelatin (GEL) scaffolds with a wide spectrum of biophysical and pharmacological properties. The tailored addition of FA (≤0.2 …
PVA as binder in continuous twin-screw granulation
Introduction
Granulation of powder blends is a commonly applied technique for pharmaceutical formulations which have no suitable flowability or compactability or are inhomogeneous with regards to the API content. Mainly wet granulation is…
Pre and post characterization of ODTs with emphasis on compression force and quality of…
Oral dispersible tablets (ODTs) are patient compliant dosage forms which rapidly disintegrate in the mouth following active absorption with rapid onset of action. The current study was designed to resolve compression problems used for ODTs,…
Expanded porous-starch matrix as an alternative to porous starch granule: Present status,…
Abstract
Exposing the hydrated-soft-starch matrix of intact grain or reconstituted flour dough to a high-temperature-short-time (HTST) leads to rapid vapor generation that facilitates high-pressure build-up in its elastic matrix linked to…
Comparison of Two Grafted Copolymers, Soluplus and Kollicoat IR, as Solid Dispersion Carriers of…
Arteether (ART), an antimalarial drug, belongs to BCS class II and has very low oral bioavailability. Clinically, it is given as a solution in oil by the intramuscular route. Solid dispersion in Soluplus or Kollicoat IR, two commonly used…
Sensitivity analysis of the formation of hollow solid lipid micro- and nanoparticles from…
Abstract
The production of hollow solid micro- and nanoparticles using fully hydrogenated soybean oil (FHSO) and supercritical carbon dioxide (SC-CO2) has been studied in the literature. This research aimed to examine the impact of FHSO…
Nanocrystalline solid dispersions: an emerging approach for oral bioavailability enhancement of…
The bioavailability of lapatinib ditosylate, an active anticancer agent against breast neoplasms, is constrained by its poor bioavailability due to poor aqueous solubility. So, the study’s objective was to develop its nanocrystalline solid…
Injectable systems for long-lasting insulin therapy
Abstract
Insulin therapy is the mainstay to treat diabetes characterizedd by hyperglycemia. However, its short half-life of only 4–6 min limits its effectiveness in treating chronic diabetes. Advances in recombinant DNA technology and…
Enhancing Dissolution Efficiency of Ketoprofen, A Rheumatoid Arthritis Pain Management Drug, through…
This article is part of the issue: PROCEEDINGS OF THE INTERNATIONAL CONFERENCE OF THE CHINESE RHEUMATOLOGISTS (ICCR) 25–26 November 2023
Abstract
Background
Ketoprofen (KPN) is commonly prescribed drug to…
Topical delivery of nanoemulsions for skin cancer treatment
Skin cancer chemotherapeutics often lead to the development of severe cytotoxicity, compelling the development of novel delivery systems to not only enhance therapeutic efficacy but also minimize side effects and improve patient compliance.…
A pH-sensitive silica nanoparticles for colon-specific delivery and controlled release of catechin:…
Catechin is a naturally occurring flavonoid of the flavan-3-ol subclass with numerous biological functions; however, these benefits are diminished due to several factors, including low water solubility and degradation in the stomach's harsh…
Revolutionary Advancements in Fast Dissolving Tablets: An In-Depth Exploration
ABSTRACT
A novel drug delivery system plays a pivotal role in enhancing patient adherence to medication regimens. Among these innovative approaches, fast dissolving tablets (FDT’s) stand out as a particularly promising option. FDT’s offer…
InhaLac® 145 – The interview
MEGGLE announced the release of its new lactose product InhaLac® 145 yesterday.
Pharma Excipients had the opportunity to speak with Dr. Constanze Müller, Manager Business Development Inhalation and one of the persons behind the…
Quality by design (QbD) commended exploration of bosutinib loaded lipid nanocarriers for food effect…
Abstract
Bosutinib (BOS), a BCS class IV drug suffers from poor aqueous solubility and bioavailability along with significant food effect. Lipid nanocarriers (LNC) have the potential to circumvent bioavailability related issues associated…
Development of inhalation powders containing lactic acid bacteria with antimicrobial activity…
Abstract
Objectives
The aim of the project was to develop and characterise powders containing a probiotic (Lactiplantibacillus plantarum , Lacticaseibacillus rhamnosus, or Lactobacillus acidophilus) to be administered to the lung for…
Monitoring low dose API blend uniformity with Parteck® M mannitol using near-infrared (NIR)…
Direct compression is often used for tablet manufacturing because it is the shortest, most effective, and least complex method. The physical properties of active pharmaceutical ingredients (APIs) can, however, create a challenge for…
InhaLac® 145 – MEGGLE launches new milled lactose grade
Wasserburg, Germany, December, 2023:
Pharmaceutical lactose specialist MEGGLE will use the Drug Delivery to the Lungs (DDL) Conference in Edinburgh, Scotland, to launch InhaLac® 145 as the latest addition to its wide range of…
The use of polymorphic state modifiers in solid lipid microparticles: The role of structural…
This study investigates the correlation between the structural and release properties of solid lipid microparticles (MPs) of tristearin containing 5 % w/w of four different liquid additives used as crystal modifiers: isopropyl myristate…
Development of a novel squalene/a-tocopherol-based self-emulsified nanoemulsion incorporating…
Abstract
Vaccination has emerged as the most effective strategy to confront infectious diseases, among which is leishmaniasis, that threat public health. Despite laborious efforts there is still no vaccine for humans to confront…
Electroactive Polymers for On-Demand Drug Release
Abstract
Conductive materials have played a significant role in advancing society into the digital era. Such materials are able to harness the power of electricity and are used to control many aspects of daily life. Conductive polymers…
Lipoid launches new product quality for LIPOID PE 18:1
Lipoid is dedicated to continuously optimizing its production processes and product portfolio. For their product LIPOID PE 18:1/18:1 (DOPE), they are now launching a new product quality. The new product quality allows rapid and complete…
Fabrication of dissolving microneedles for transdermal delivery of protein and peptide drugs:…
Proteins and peptides are rapidly developing pharmaceutical products and are expected to continue growing in the future. However, due to their nature, their delivery is often limited to injection, with drawbacks such as pain and needle…
Quantitative imaging of doxorubicin diffusion and cellular uptake in biomimetic gels with human…
Novel tumor-on-a-chip approaches are increasingly used to investigate tumor progression and potential treatment options. To improve the effect of any cancer treatment it is important to have an in depth understanding of drug diffusion,…
Retrospective analysis of the biopharmaceutics characteristics of solid oral Modified-Release drug…
Abstract
Background
Modified Release (MR) orally administered drugs products differ from Immediate-Release (IR) drug products in their drug release site and/or rate to offer therapeutic advantages. It is important to understand the…
Desloratadine-Loaded Flexible Orally Dissolvable Tablets Made of Electrospun Fiber Mats
Patient compliance and personalized dose adjustments are important factors, especially in pediatric care. Orodispersible tablets (ODTs) are gaining importance as they increase patient compliance compared to other solid oral dosage forms.…
Aerogels as Carriers for Oral Administration of Drugs: An Approach towards Colonic Delivery
Polysaccharide aerogels have emerged as a highly promising technology in the field of oral drug delivery. These nanoporous, ultralight materials, derived from natural polysaccharides such as cellulose, starch, or chitin, have significant…
The step-wise dissolution method: An efficient DSC-based protocol for verification of predicted…
Abstract
The development of an amorphous solid dispersion (ASD) is a promising strategy for improving the low bioavailability of many poorly water-soluble active pharmaceutical ingredients (APIs). The construction of a…
Enabling late-stage drug diversification by high-throughput experimentation with geometric deep…
Late-stage functionalization is an economical approach to optimize the properties of drug candidates. However, the chemical complexity of drug molecules often makes late-stage diversification challenging. To address this problem, a…