Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
Improving Solubility of the Telmisartan that is Poorly Water Soluble by Wet Granulation and…
08. August 2018
Telmisartan (TS) have developed for the treatment of hypertension as the angiotensin II receptor blocker. TS belongs to class II drug in BCS classification and it has good permeability. But, it…
Technologies to Improve the Solubility, Dissolution and Bioavailability of Poorly Soluble Drugs
08. August 2018
Combinatorial chemistry, computational molecular modeling and high throughput screening in drug discovery have significantly increased the number of poorly soluble drugs. About 40% of drugs developed in the…
Effects of pharmaceutical processes on the quality of ethylcellulose coated pellets: Quality by…
The main purpose of this study was to investigate the influence of ethylcellulose (EC) coating and curing conditions on the quality attributes of pharmaceutical pellets prepared using a quality bydesign (QbD) approach. The drug release rate…
3D printed drug products: Non-destructive dose verification using a rapid point-and-shoot approach
08. August 2018
Three-dimensional printing (3DP) has the potential to cause a paradigm shift in the manufacture of pharmaceuticals, enabling personalised medicines to be produced on-demand. To facilitate…
Polymeric Gels: Vehicles for Enhanced Drug Delivery Across Skin
08. August 2018
Polymeric gels have emerged as promising vehicles for drug delivery across the skin. Stratum corneum, the topmost layer of the skin, does not allow hydrophilic and high molecular weight drugs…
Inkjet Printing of T3 and T4 Oral Drug Combinations as a Novel Strategy for Hypothyroidism
06. August 2018
Hypothyroidism is a chronic and debilitating disease that is estimated to affect 3% of the general population. Clinical experience has highlighted the synergistic value of combining…
DEM simulation of the mixing behavior in a spheronization process
06. August 2018
Spherical pellets for pharmaceutical applications are widely produced by an extrusion-spheronization process. To achieve an equal, spherical pellet shape with a spheronization process, it is…
Cold chain logistics – Special field of competence in Glatt’s Pharma Logistic Center
06. August 2018
The Glatt pharma logistic center has now established a cold chain logistics organization and infrastructure which is state-of-the-art and which exactly addresses the costumer’s needs.
…
Excipients Used in Oral Nanocarrier-Based Formulations
06. August 2018
Chapter 10 "Excipients Used in Oral Nanocarrier-Based Formulations" by Rajan Jog and Diane Burgess mentioned in the title is part of the Book:
Fundamentals of Nanoparticles - 1st…
Strategies to overcome the polycation dilemma in drug delivery
04. August 2018
Because of polycationic auxiliary agents such as chitosan, polyethyleneimine and cell-penetrating peptides as well as cationic lipids assembling to polycationic systems, drug carriers can tightly…
Enhancement of the solubility, stability and bioaccessibility of quercetin using protein-based…
04. August 2018 Emulsion-based excipient foods were developed to improve the bioaccessibility of an important hydrophobic nutraceutical: quercetin. Protein-stabilized…
Aspartame as a co-former in co-amorphous systems
04. August 2018 Co-amorphous drug delivery systems are a promising approach to improve the dissolution rate and therefore potentially the oral bioavailability of poorly-water…
In situ crystallization kinetics and behavior of mannitol during droplet drying
04. August 2018 In this paper, we explain the crystallization process of mannitol during convective droplet drying based on the crystallization kinetics calculated from two…
Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific…
01. August 2018
Advancements in in silico techniques of lead molecule selection have resulted in the failure of around 70% of new chemical entities (NCEs). Some of these molecules are getting rejected at final…
The solubility–permeability interplay and oral drug formulation design: Two heads are better than…
31. July 2018
Poor aqueous solubility is a major challenge in today's biopharmaceutics. While solubility-enabling formulations can significantly increase the apparent solubility of the drug, the concomitant effect…
Are Injection Site Reactions in Monoclonal Antibody Therapies caused by Polysorbate Excipient…
30. July 2018
Injection site reactions (ISRs) and other adverse side-effects are commonly observed during therapy with biologics. These hypersensitivity related side-effects can vary from simple rash…
Influence and effect of osmolytes in biopharmaceutical formulations
30. July 2018
Osmolytes are small organic molecules accumulated by cells in response to environmental stresses. They are represented by amino acids, sugars, polyols, tertiary sulphonium and quaternary…
Dosing considerations for inhaled biologics
30. July 2018 The number of biologics in the therapeutic development pipeline is increasing including those delivered though inhalation (Morales, 2017; Fathe, 2016). Biologics…
3D printing of tablets containing amorphous aripiprazole by filaments co-extrusion
30. July 2018
Three-dimensional printing is one of the fastest developing technology within the pharmaceutical field. With many advantages this method can be found as a new dosage form manufacturing technique, however low…
Bioavailability Enhancement of Poorly Water-Soluble Drugs via Nanocomposites: Formulation–Processing…
30. July 2018
Drug nanoparticles embedded in a dispersant matrix as a secondary phase, i.e., drug-loaden nanocomposites, offer a versatile delivery platform for enhancing the dissolution rate and bioavailability…
Oral Delivery of Macromolecular Drugs
30. July 2018
Small-molecule drugs in oral solid-dosage forms are considered the first line of defense in treating diseases of the gastrointestinal (GI) tract, which affect millions of patients around the world…
Solubilization of drugs using sodium lauryl sulfate: Experimental data and modeling
30. July 2018
Micellar solubilization is a great method for increasing drugs solubility in aqueous environments. At concentrations above the critical micelle concentration (CMC), micelles are formed and they…
Organic acids as co-formers for co-amorphous systems – Influence of variation in molar ratio on the…
27. July 2018
Co-amorphous drug delivery systems are attracting increasing attention in the pharmaceutical field, due to their promising potential to improve the solubility and bioavailability of poorly…
Storage stability and solubilization ability of HPMC in curcumin amorphous solid dispersions…
27. July 2018
The present study elucidated the advantages of using hydroxypropyl methylcellulose E5 (HPMC) as auxiliary excipient in maintaining storage stability and solubilization ability for curcumin…
Factors influencing the design of a multiparticulate dosing device
26. July 2018
Paediatric specific medicines have become increasingly researched since the introduction of paediatric investigation plan requirements in 2007. Various dosage forms continue to be investigated for…
Microstructural distinction of electrospun nanofibrous drug delivery systems formulated with…
25. July 2018
The electrospun nanofiber-based orally dissolving webs are promising candidates for rapid drug release, which is due to the high surface area to volume ratio of the fibers and the high…
Novel salts of dipicolinic acid as viscosity modifiers for high concentration antibody solutions
25. July 2018
Concentrated monoclonal antibody (mAb) solutions can lead to high viscosity as a result of protein-protein interactions and pose challenges for manufacture. Dipicolinic acid (DPA,…
Novel dry powder inhaler formulation containing antibiotic using combined technology to improve…
25. July 2018 Dry Powder Inhaler (DPI) could offer a propellant-free, easy-to-use powder form ensuring better stability than liquid dosae…
What are Sweeteners? An introduction to pharmaceutical sweetener excipients
There are a multitude of sweeteners available to the pharmaceutical scientist. Sweeteners may be broadly grouped into two categories – nutritive and non-nutritive. Nutritive sweeteners deliver calories and as their name suggests,…
Development of TCM-based composite particles for direct compaction by particle design
21. July 2018
The Andrographis herba extract (AHE), a traditional Chinese medicine (TCM), was developed to directly compactible powders by fluid bed coating with 6% to 12% hydroxypropyl methylcellulose (HPMC).…
Analysis of the Literature and Patents on Solid Dispersions from 1980 to 2015
20. July 2018
Solid dispersions are an effective formulation technique to improve the solubility, dissolution rate, and bioavailability of water-insoluble drugs for oral delivery. In the last 15 years, increased…
3D printed medicines: A new branch of digital healthcare
Three-dimensional printing (3DP) is a highly disruptive technology with the potential to change the way pharmaceuticals are designed, prescribed and produced. Owing to its low cost, diversity, portability and simplicity, fused deposition…
Get Regulatory Updates and Information on Soluplus®
20. July 2018
Soluplus® has been approved in generics in Taiwan and Argentina and now filed in Brazil. Would like to be kept updated on Soluplus® regulatory status or need further Information? Sign up here!…
Non-Invasive Nasal Hydromorphone with High Bioavailability for Rapid Onset and Non-Dissociative…
19. July 2018
Achieving pain control in acute pain situations such as battlefield injury, EMS first responders, emergency department cases and breakthrough cancer pain has quite often proved challenging . Although opioid…