Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges
19. July 2018
This is a must read article for anybody involved or interested in 3D printing. It covers all different aspects including the excipients which play quite a role in this technology.
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Soluplus® is approved in generics in Taiwan and Argentina and is now filed in Brazil!
19. July 2018
Did you know that Soluplus® is already approved in generics in Taiwan and Argentina and now filed in Brazil? Check the submentioned Soluplus® one pager with updated regulatory status per country.…
Challenges in Transitioning Cocrystals from Bench to Bedside: Dissociation in Prototype Drug Product…
18. July 2018
Tablets containing a theophylline–glutaric acid (TG) cocrystal dissociated rapidly forming crystalline theophylline (20–30%), following storage at 40 °C/75% RH for 2 weeks. Control tablets of TG cocrystal…
ExcipientFest Americas becomes Excipient World
17. July 2018
In May 2018 IPEC-Americas acquired ExcipientFest Americas and re-branded it "Excipient World". According to the organizers "Excipient World will continue the tradition of producing high quality…
Spectroscopic characterization of tablet properties in a continuous powder blending and tableting…
17. July 2018
By the advent of continuous pharmaceutical manufacturing, fast and accurate characterization of product quality has become of a major interest. Although it also promotes the real-time release…
Dry Particle Coating – A unique Solution for Pharmaceutical Formulation
17. July 2018
Particle surface modification is becoming an important strategy in the pharmaceutical industry for “difficult to formulate” APIs. Most surface modification techniques, however, alter innate…
Call for Educational Session Proposals for Excipient World 2019
17. July 2018
This year's theme: The Evolving Global Role of Excipients
Proposals due: July 27rd, 2018
Submit Topics to: Topic Submission Form
Excipient World - IPEC-Americas premier excipient event -…
Excipients Inside June 2018 – IPEC Europe
16. July 2018
Dear readers,
It’s hard to believe that we’re issuing our June publication already and we find ourselves heading for the summer break. And of course, we’re now preparing for those mid-year reviews to…
Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing
14. June 2018
The pharmaceutical industry has found new applications for the use of continuous processing for the manufacture of new therapies currently in development. The transformation has been encouraged by…
Glatt TwinPro® – the Fusion of two Batch Processes
14. June 2018
The brand new Glatt TwinPro® is absolutely revolutionary. It combines two previously single batch processes into one single process: High Shear Granulation and Fluidized Bed Drying. Critical…
Selecting Excipients for Liquid-Filled Hard Capsules
Thixotropic gels, thermosoftened systems, and self-emulsifying systems have expanded the range of potential excipients.
Liquid-filled hard capsules (LFHCs) are typically composed of a shell of gelatin or hydroxypropyl…
Excipient standards – Ask an Expert
13. July 2018
Q: What standards should my excipient supplier meet for excipient quality?
A: Jim Morris, NSF Health Sciences, a division of NSF International says:
Historically,…
Drug Products: Generate cash flow advantages on the import tax (VAT) by making use of a fiscal…
13. July 2018
Neither a non-EU nor an EU company that have a VAT registration can easily use the VAT transit rule when importing drug products. This means that VAT has to be paid on imports of goods from outside…
Preventing Film Coating Problems by Design
"Common defects in tablet film coating can be minimized by effective design of the tablet core and the coating process." Stuart C. Porter in Pharmaceutical Technology
Film coatings on pharmaceutical tablets provide a broad range of…
ReForm Biologics Announces New Patent on Surfactant Replacement Excipients to Stabilize…
11. July 2018
New surfactant replacement offers a promising alternative to polysorbates for stabilizing proteins
CAMBRIDGE, Mass. – July 11, 2018 – ReForm Biologics, a pharmaceutical technology company…
Ideal Cures Launches Two New Film Coating Products INSTACOAT QD and INSTACOAT T2F at the 2nd FDD…
10. July 2018
In a joint initiative, Ideal Cures - India's foremost film-coating and pharmaceutical excipient company - along with Express Pharma, India's leading pharmaceutical and biotechnology publication, in their…
Biologic Excipients Market is expected to be valued at US$ 1,706.2 million by the end of 2028
10. July 2018
Future Market Insights (FMI) delivers key insights on the global biologic excipients market in its upcoming report titled “Biologic Excipients Market: Global Industry Analysis 2013–2017 and Opportunity…
Deciphering Magnesium Stearate Thermotropic Behavior
08. July 2018
Magnesium stearate (MgSt) is the most commonly used excipient for oral solid dosage forms, yet there is significant commercial physicochemical variability that can lead to variable performance of…
Self-microemulsifying tablets prepared by direct compression for improved resveratrol delivery
08. July 2018
The purpose of this study was to develop self-microemulsifying (SME-) tablets to improve resveratrol solubility whilst delivering resveratrol in a preferred tablet dosage form. Resveratrol was…
A new excipient for direct compression and dry granulation with enormous hardness yield –…
08. July 2018
Tricalcium citrate (TCC) was characterized as a tableting excipient for direct compression (DC) and dry granulation (DG).
Significance: Brittle materials usually lead to tablets of…
Excipients: Kano Analysis and Quality by Design
07. July 2018
“If formulation science is the Cinderella of drug development, then excipients are the Cinderellas of formulation science”.
R. C. Moreton, Finn Brit Consulting
This chapter assumes some…
Unintended effects of drug carriers: Big issues of small particles
07. July 2018
Humoral and cellular host defense mechanisms including diverse phagocytes, leukocytes, and immune cells have evolved over millions of years to protect the body from microbes and other external and…
Microcrystalline cellulose, lactose and lignin blends: Process mapping of dry granulation via roll…
07. July 2018
In this study, a process map was developed in an effort to improve the understanding of dry granulation of pharmaceutical excipients by roll compaction process, and to implement the…
Dosing challenges in respiratory therapies
07. July 2018
The pulmonary route of administration has been commonly used for local lung conditions such as asthma and chronic obstructive pulmonary disease (COPD). Recently, with the advent of new…
The Broken Antibiotics Business Model Part I
05. July 2018 Antimicrobial resistance and its resulting dire consequences have finally become well recognized. Still, the problem continues to proliferate, killing…
The Broken Antibiotics Business Model Part II
05. July 2018
In part I of this series, I wrote about the financial unsustainability of antibiotics development. Revenues and profits of the new therapies launched since 2010 do not match the costs of…
Influence of the solvent system on the stability of doxycycline solutions
04. July 2018
Concentrated solutions of doxycycline are often added to drinking water of animals for oral antibiotic therapy. However, stability concerns of doxycycline in solution involve an accurate selection…
Improved tableting behavior of paracetamol in the presence of polyvinylpyrrolidone additive: Effect…
04. July 2018
Monoclinic paracetamol (PA) is notorious as a poorly compactible model drug. Polyvinylpyrrolidone (PVP) is a polymer that can act as an effective binder to improve the mechanical properties of PA.…
Acceptability of Multiple Uncoated Minitablets in Infants and Toddlers: A Randomized Controlled…
04. July 2018
The objective of this study was to assess the acceptability and swallowability of several minitablets when administered as a unit dose compared with an equivalent dose of syrup in children aged 6…
Excipients: not so inert? When the excipient plays the role of an active substance, as exemplified…
04. July 2018
It is well recognised that the historical timeline required for developing a drug, beginning with target identification and validation, is long and often tedious. It requires a large set of competences in…
Tablet Authentication: Current state and optimized solutions
04. July 2018
Global trade means that extra effort is required to protect one's products from the manufacturing line through distribution to the point of sale. In particular, it is not enough to track and trace packaged…
Optimize the handling of your quality documents of pharmaceutical raw material manufacturers?
04. July 2018
Are you a pharmaceutical raw material producer and would like to optimize the handling of your quality documents?
Then you might find the Solutions by Qualit-E of interest!
…
Nanoparticle debate: Replacement of TiO2 in Filmcoatings?
03. July 2018
The French authorities communicated the plan to ban Titan Dioxide from food products by end to this year.
Who will follow the French example?
What will be the impact for the pharmaceutical…
Co-Processed Excipients for Dispersible Tablets—Part 2: Patient Acceptability
02. July 2018
Palatability and patient acceptability are critical attributes of dispersible tablet formulation. Co-processed excipients could provide improved organoleptic profile due to rational choice of…