Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Novel Extended-Release Multiple-Unit System of Imidafenacin Prepared by Fluid-Bed Coating Technique
27. June 2018
The objective of this study was to formulate once-a-day extended-release (ER) pellet system of imidafenacin (IDN), a recently approved urinary antispasmodic agent with twice-a-day dosing regimen.…
Challenges in Protein Product Development – Book
27. June 2018
In this volume, the authors discuss the many significant challenges currently faced in biotechnology dosage form development, providing guidance, shared experience and thoughtful reflection on how…
High-speed picking process – Special Topic Pharma Logistics
27. June 2018
Pick-by-Voice is a picking solution that enables the packaging operators to control the picking process by receiving spoken commands and giving acoustic feedback. Correct picking situation this way…
Pellets and Micropellets for multiparticulate dosage forms
26. June 2018
TTC Workshop 16 – 18 OCTOBER 2018 in Binzen Germany
More and more pharmaceutical products are reaching the market as multiparticulate dosage forms, mainly as pellets. The healthcare sector also…
Power consumption during oscillatory mixing of pharmaceutical powders
25. June 2018
The blending of powders is a critical step in pharmaceutical drug product manufacturing as it ensures that each dosage unit will contain the same intended fraction of active pharmaceutical…
Regulatory Aspects of Pharmaceutical Excipients in India and their Qualification to Use in…
Excipients are an inactive substances formulated along with the active pharmaceutical ingredient(s) (APIs) of medication for bulking up of formulations or to give a therapeutic enhancement of API in the final dosage form. Almost…
Co-Processed Excipients for Dispersible Tablets Part 1: Manufacturability
24. June 2018
Co-processed excipients may enhance functionality and reduce drawbacks of traditional excipients for the manufacture of tablets on a commercial scale. The following study aimed to characterise a…
Tricalcium Citrate – A New Brittle Tableting Excipient for Direct Compression and Dry…
21. June 2018
Tricalcium citrate (TCC) was characterized as a tableting excipient for direct compression (DC) and dry granulation (DG).
SIGNIFICANCE:
Brittle materials usually lead to tablets of…
Day 1 Highlights @ CPhI & P-MEC China 2018
21. June 2018
Day 1 Highlights @ CPhI & P-MEC China 2018
A short video on the highlights of the first day @ CPhI & P-MEC China.
Import of Pharmaceutical and Medicinal Product into Europe
21. June 2018
The European Union is a large importer of medicinal and pharmaceutical products. Its main trading partners are the United States and Switzerland but also Brazil, China, Israel, India, South Korea,…
How can Deformulation / Reverse Engineering help your formulation?
21. June 2018
Reverse Engineering or Deformulation is often used to investigate the composition of a competitor’s product, but is also a powerful tool to examine or monitor formulations during development,…
Optimization of taste-masking on ibuprofen microspheres with selected structure features
20. June 2018
The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and…
Application of hydroxypropyl methylcellulose as a protective agent against magnesium stearate…
20. June 2018
Itraconazole is a fungicide drug which has low bioavailability due to its poor water solubility. Amorphous solid dispersion (ASD) is a tool that has the potential to greatly increase the…
Inhalation Insights – DPI Technology Symposium
19. June 2018
2018 | July 5 | Kuala Lumpur | Malaysia
Why attend?
First-hand knowledge related to DPI technology along the complete process chain (from powder characteristics and formulations,…
Top Pharma & Biotech Deals, Investments and M&As in May 2018
18. June 2018
Top Pharma & Biotech Deals, Investments and M&As in May 2018
As April 2018 breezed past with news of Novartis’ US$ 8.7 billion buyout of AveXis, May set the temperatures soaring with one of…
The Gelucire® family – semi-solid excipients by Gattefossé
Gelucire® is Gattefossé’s brand of semi-solid excipients originally designed for hard gelatin capsule molding. The name results from the fusion between « gélule » meaning capsule and « cire » meaning wax. Following the name, there is a set…
Are you facing the challenge to replace titanium dioxide (TiO2) in your coating formulations?
Sponsored content
For decades, TiO2 is used as a white pigment due toits very high opacity and brightness. Therefore, it has a wide range of applications, from colouring ingredient of pharmaceutical film coating, to food…
Multivariate monitoring for the industrialisation of a continuous wet granulation tableting process
16. June 2018
The pharmaceutical industry is undergoing a significant change in product development and manufacturing strategies with the progressive shift from batch to continuous processes. These typically…
Evaluation of the super disintegrant functionalities of alginic acid and calcium alginate for the…
15. June 2018
This study explores the influence of different synthesis methods and drying conditions in the preparation of sodium alginate-derivate xerogels presenting interesting disintegrant…
Semisolid self-microemulsifying drug delivery systems (SMEDDSs): Effects on pharmacokinetics of…
15. June 2018
Semisolid self-microemulsifying drug delivery system (SMEDDS) with optimized drugloading capacity, stability, dispersibility in aqueous media and invitro drug release profile, was evaluated in vivo regarding…
Excipients in Parenteral Formulations: Selection Considerations and Effective Utilization with Small…
12. June 2018 Excipients form a major component of pharmaceutical formulations and are classified as any ingredient other than the active ingredient which is included within…
Protein-excipient interactions evaluated via NMR studies in polysorbate based multi-dose protein…
12. June 2018
Preservatives are excipients essentially needed in pharmaceutical multi-dose formulations to prevent microbial growth. Among available substances, phenol is widely used for parenterals, however, it…
Measure the coating thickness and characteristics of tablets or pellets
10. June 2018
The focus of the OSeeT are enteric coatings (EC) and modified-release (MR) coatings.
The characteristics of the coating layer are revealed via OSeeT:
Mean coating thickness
→ progress…
Development and evaluation of terbutaline sulfate orally disintegrating tablets by direct…
07. June 2018
Asthma is a chronic respiratory condition characterized by attacks of spasm in the bronchi of the lungs, causing difficulty in breathing. Oral and inhalation routes are generally used for the…
3D-Printed Network Structures as Controlled-Release Drug Delivery Systems: Dose Adjustment, API…
07. June 2018
3D printing evolved as a promising technique to improve individualization of drug therapy. In particular, when printing sustained release solid dosage forms, as for instance implants, inserts,…
Poly(2-ethyl-2-oxazoline) as an Alternative to Poly(vinylpyrrolidone) in Solid Dispersions for…
07. June 2018
Poly(2-ethyl-2-oxazoline) (PEOX), a biocompatible polymer considered as a pseudo polypeptide, was introduced as a potential alternative to the commonly used polymer, poly(vinylpyrrolidone) (PVP) for the…
Does the performance of wet granulation and tablet hardness affect the drug dissolution profile of…
07. June 2018
Wet granulation is mostly used process for manufacturing matrix tablets. Compared to the direct compression method, it allows for a better flow and compressibility properties of compression mixtures.…
Continuous end-to-end production of solid drug dosage forms: Coupling flow synthesis and formulation…
07. June 2018
Based on the concept of continuous manufacturing an end-to-end benchtop device was developed unprecedented for the production of solid drug dosage forms by connecting flow synthesis and formulation…
MeltPrep – Rapid and Lossless Screening of Hot-melt Extruded Formulations
06. June 2018
Hot-melt extrusion is well established in the plastics industry and is applied in pharmaceutical application for more than 30 years. In contrast to plastics, pharmaceutical formulation development…
Infacort®, Oral Hydrocortisone Granules with Taste Masking for the Treatment of Neonates and Infants…
05. March 2015
Background: Current treatment for adrenal insufficiency in neonates and infants is unsatisfactory as unlicensed adult formulations are used and the minimum unit dose available is a scored 5mg hydrocortisone…
Expanding the Application and Formulation Space of Amorphous Solid Dispersions with KinetiSol®
05. June 2018
Due to the high number of poorly soluble drugs in the development pipeline, novel processes for delivery of these challenging molecules are increasingly in demand. One such emerging method is KinetiSol, which…
Tablets made from paper
05. June 2018
The possibility to compress ordinary paper into tablets was systematically investigated in this study. Results proved that tablets can be made from paper, independent of the type of paper used. The…
HPMC-Eudragit-Based Gastro-retentive Hydrodynamically Balanced System
04. June 2018
In this study HPMC-eudragit based hydrodynamically balanced capsules of two model drugs; propranolol HCl and ofloxacin were prepared with the aim to have the gastric retention of the systems for…
Excipient Selection Considerations
The selection of the excipients(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be
Dose…