Mucosal Penetrative Polymeric Micelle Formulations for Insulin Delivery to the Respiratory Tract
Abstract
Purpose: Effective mucosal delivery of drugs continues to pose a significant challenge owing to the formidable barrier presented by the respiratory tract mucus, which efficiently traps and clears foreign particulates. The surface characteristics of micelles dictate their ability to penetrate the respiratory tract mucus. In this study,…
HPMC-Eudragit-Based Gastro-retentive Hydrodynamically Balanced System
04. June 2018
In this study HPMC-eudragit based hydrodynamically balanced capsules of two model drugs; propranolol HCl and ofloxacin were prepared with the aim to have the gastric retention of the systems for…
Excipient Selection Considerations
The selection of the excipients(s) for a tablet formulation should take into account the API properties, process, target formulation and potential impact on the formulation. Some of those API properties can be
Dose…
New solution for secure sharing of quality documents for excipients and API’s
04. June 2018
Are you a pharmaceutical raw material producer and would like to optimize the handling of your quality documents?
Be ahead of the curve
As a pharmaceutical raw material producer, sending…
Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive…
04. June 2018
Complex hydrogels formed with chitosan (CS) and ring-opened polyvinyl pyrrolidone (roPVP) as a swellable mucoadhesive gastroretentive drug dosage form (smGRDDF) were prepared and characterized.…
Glyceryl ester surfactants: Promising excipients to enhance the cell permeating properties of SEDDS
02. June 2018 The aim of the study is the evaluation of the impact of glyceryl ester surfactants on cell permeating properties of SEDDS (self-emulsifying drug delivery…
Moisture sorption and diffusion determination of Chinese Herbal Granules: moisture-resistant effects…
02. June 2018 The objective of this article is to investigate the effects of fluidized bed granulation with dextrin on moisture sorption and diffusion of Zexie Decoction…
A review on pH and temperature responsive gels and other less explored drug delivery systems
02. June 2018
Any imbalance in body's pH or temperature may alter immune response and lead to conditions such as autoimmune disorders, infectious diseases, cancer and diabetes. Dual pH and thermo-responsive…
A donepezil/cyclodextrin complexation orodispersible film: effect of cyclodextrin on taste-masking
30. May 2018 The aim of this study was to develop a palatable donepezil (DP) orodispersible film (ODF) to facilitate the swallowing process and investigate the effect of…
Self-assembled liposome from multi-layered fibrous mucoadhesive membrane for buccal delivery of…
30. May 2018 A novel delivery system based on self-assembled liposome from multi-layered fibrous mucoadhesive membrane has been developed to improve the bioavailability of…
Research Progress in In-situ Gelling Ophthalmic Drug Delivery System
30. May 2018 Blindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden.…
Reshaping drug development using 3D printing
30. May 2018 The pharmaceutical industry stands on the brink of a revolution, calling for the recognition and embracement of novel techniques. 3D printing (3DP) is forecast to…
APV / IPEC Europe Excipient Conference
30. May 2018
18-19 September 2018 in Cologne - Germany
OBJECTIVES
Implementation of GMP in an excipient manufacturing site
Qualification and auditing of suppliers
Analytical data and certificates of…
Comparative evaluation of powder flow parameters with reference to particle size and shape
29. May 2018 Powder flow is critical to the success of various pharmaceutical processes such as tableting and capsule filling. Despite a plethora of flow characterisation…
Characterization of mannitol granules and powder: A comparative study using two flowability testers
In the manufacture of tablets, especially in direct tableting processes, the flowability of excipient powders and formulated powders is one of the most important characteristics. In the past two decades, orally disintegrating tablets (ODTs)…
Development of probiotic-loaded microcapsules for local delivery
29. May 2018 The delivery of probiotics to different sites of action within the human body might help to prevent and treat several diseases. Here, we describe a…
Prolonged drug release properties for orodispersible films by combining hot-melt extrusion and…
28. May 2018
Orodispersible films (ODFs) are an advantageous dosage form to accomplish patient convenience and compliance in oral drug delivery. They provide a number of special application features, such as the…
Degradation caused by incompatibility between sodium stearyl fumarate (PRUV) and AZD7986 in the drug…
28. May 2018 During compatibility study of the AZD7986 project, a peak of 3 area% at the tail (RRT 1.03) of the active pharmaceutical ingredient (API) was discovered…
Interaction of Mannitol and Sucrose with Gellan Gum in Freeze-Dried Gel Systems
28. May 2018 The effect of sucrose and mannitol addition to low-acyl (LA) gellan gum gels at both the molecular and macroscopic levels prior to, and after freeze-drying has…
In Vitro Evaluation of 2D-Printed Edible Films for the Buccal Delivery of Diclofenac Sodium
28. May 2018 Printing technologies have recently emerged in the development of novel drug delivery systems toward personalized medicine, to improve the performance of…
Early assessment of bulk powder processability as a part of solid form screening
27. May 2018 A systematic assessment of key material attributes of active pharmaceutical ingredients (APIs) using minimal material approach is illustrated at the…
Hot-melt coating with Precirol ATO 5 in a fluidized-bed apparatus: Application of experimental…
26. May 2018 Hot-melt coating is a novel and cost-effective solvent-free coating technique. Commonly used excipients for hot-melt coating are lipid substances. In…
pH-independent controlled release tablets containing nanonizing valsartan solid dispersions for less…
26. May 2018
The aims of this work were to design pH-independent controlled release (CR) tablet containing nanonizing solid dispersion (SD) adsorbed on hydrophilic silica (Aeroperl® 300/30). Valsartan (VAL) was chosen to…
Novel excipients – Regulatory challenges and perspectives – The EU insight
26. May 2018 Novel excipients are indispensable in development of modern, advanced drug delivery systems and biotechnology-derived drugs. Although numerous novel excipients are…
Polymer-lipid hybrid nanoparticles as enhanced indomethacin delivery systems
24. May 2018 Non-steroidal anti-inflammatory drugs (NSAIDs), i.e. indomethacin used for rheumatoid arthritis and non-rheumatoid inflammatory diseases, are known for their…
Improving maraviroc oral bioavailability by formation of solid drug nanoparticles
24. May 2018 Oral drug administration remains the preferred approach for treatment of HIV in most patients. Maraviroc (MVC) is the first in class co-receptor antagonist,…
Formulation Techniques for High Dose Dry Powders
23. May 2018 Delivery of drugs to the lungs via dry powder inhaler (DPI) is a promising approach for the treatment of both local pulmonary conditions and systemic diseases.…
How are Flavors created? Second Article of “Excipient Basics” Series
23. May 2018 Flavors are blends of aroma chemicals that are developed for specific end-use applications. The exact composition of flavors is proprietary – it’s the…
France to ban controversial food additive Titan Dioxide (E171) still this year
22. May 2018 France is to suspend a widely used food additive found in sweets, pastries and even bread by the end of the year, after studies suggested it may cause…
The next generation pharma skills you will need in view of continuous manufacturing
22. May 2018
Exclusive 3-day training by leading academic, industry and regulatory experts
11 - 13 September 2018 in Binzen, Germany
This exclusive pharma training event brings together leading academic,…
Effect of excipient properties, water activity and water content on the disproportionation of a…
21. May 2018 Excipients are crucial components of most pharmaceutical formulations. In the case of a solid oral dosage formulation containing the salt form of a weakly ionizable…
A comparative Study of the Influence of Alpha-Lactose Monohydrate Particle Morphology on Granule and…
20. May 2018 The influence of particle morphology and size of alpha-lactose monohydrate on dry granules and tablets was studied. Four different morphologies were investigated:…
Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights
20. May 2018 The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to…
The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption…
17. May 2018 Pharmaceutical excipients that may affect gastrointestinal (GI) drug absorption are called critical pharmaceutical excipients (CPEs), or absorption-modifying…
A Quantitative Disintegration Method for Polymeric Films
17. May 2018 Current in vitro disintegration methods for polymeric films are qualitative and introduce significant user bias. The goal of these studies is to…