Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
TiO2-free and natural Film Coating
16. May 2018 Do you need a tablet film coating with natural colors and TiO2-free? Pharmaexcipients.com offers the access to the film coating experts. They put…
Zein as a Pharmaceutical Excipient in Oral Solid Dosage Forms: State of the Art and Future
15. May 2018 Zein is the main storage protein of corn and it has several industrial applications. Mainly in the last 10–15 years, zein has emerged as a potential…
A quantitative analysis of drug migration during granule drying
15. May 2018 This study investigates the extent of drug (active) migration in granules made via high shear wet granulation subject to factors such as the viscosity of the…
Surface engineered excipients:II. Simultaneous milling and dry coating for preparation of fine-grade…
15. May 2018 Asolventless process for simultaneously milling and dry coating microcrystalline cellulose (MCC) was investigated for producing fine excipients in five…
Polysaccharides-based multiparticulated interpolyelectrolyte complexes for controlled benznidazole…
14. May 2018 Polysaccharides-based delivery systems and interpolyelectrolyte complexes (IPECs) are interesting alternatives to control the release of drugs, thereby…
Dodecyl Sulfate and Soluplus and the Crystallization Inhibition and Dissolution of Felodipine…
14. May 2018 The objectives of this study were to explore sodium dodecyl sulfate (SDS) and Soluplus on the crystallization inhibition and dissolution of felodipine (FLDP)…
Self-stabilized chitosan and its complexes with carboxymethyl starch as excipients in drug delivery
13. May 2018
This study focuses on the behavior of chitosan (CHI) and its polyelectrolyte complexes with carboxymethyl starch (CMS) used as monolithic matrices with acetaminophen as drug tracer. Two different chitosan…
Formulation strategies for solid oral dosage form using 3D printing technology: A mini-review
13. May 2018 3D printing: a layer-by-layer process to produce drug products has gained a lot of attention in recent years especially after its first FDA approval due to…
Evaluation of Non-Crystalline Cellulose as a Novel Excipient in Solid Dose Products
12. May 2018 The objective of this study was to evaluate non-crystalline cellulose (NCC) as a novel tablet excipient in solid oral dosage forms in comparison with…
Salt formation improved the properties of a candidate drug during early formulation development
11. May 2018 The purpose of this study was to investigate if AZD5329, a dual neurokinin NK1/2 receptor antagonist, is a suitable candidate for further development as an oral…
Modulating Sticking Propensity of Pharmaceuticals through Excipient Selection in a Direct…
10. May 2018 Purpose To investigate how excipient matrix affects punch sticking propensity of active pharmaceutical ingredients (API), with the focus on the effect of…
Evaluation of the lubricating effect of magnesium stearate and glyceryl behenate solid lipid…
09. May 2018 The aim of this study was to develop solid lipid nanoparticles (SLN) and introduce them into a direct compression process to evaluate their lubricant properties.…
Formulation design of hydroxypropyl cellulose films for use as orally disintegrating dosage forms
08. May 2018 Hydroxypropyl cellulose (HPC) is a water-soluble polymer used as a binder during pharmaceutical tableting and granulation. HPC is also known as a base material…
Supercritical antisolvent coprecipitation mechanisms
07. May 2018 Supercritical antisolvent precipitation (SAS) has been successfully used to produce microparticles and nanoparticles of controlled size and distribution either…
Design and Evaluation of Hydrophilic Matrix System for pH-Independent Sustained Release of Weakly…
07. May 2018 The aim of this research was to design and evaluate a hydrophilic matrix system for sustained release of glipizide, a weakly acidic poor soluble…
Exploiting polymer blending approach for fabrication of buccal chitosan-based composite sponges with…
06. May 2018 In the course of application and modernization of buccal dosage forms, lyophilized sponges for transmucosal drug delivery symbolize one of the most attractive…
Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo…
06. May 2018 The objective of this study was to systematically investigate the effects of surface active ophthalmic excipients on the corneal…
Different types, applications and limits of enabling excipients of pharmaceutical dosage forms
05. May 2018 Very interesting article in ScienceDirect with overview tables on different API and excipient combinations. The article includes also a list of products…
Biotech Outsourcing Strategies 2018
04. May 2018 June 19 & 20 in Basel / Switzerland Welcome to Biotech Outsourcing Strategies 2018, a new amalgamated partnering event for both stakeholders of CMC…
How close is the dose? Manipulation of 10 mg hydrocortisone tablets to provide appropriate doses to…
04. May 2018 This study explores the methodology advised by healthcare professionals and the methods used by parents/carers to identify whether there is a best practice…
Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights
The U.S. Pharmacopeia defines excipients as substances other than the active pharmaceutic ingredient (API) that are added in a drug delivery system in order to aid in the manufacturing process and enhance stability, bioavailability,…
SNEDDS and SMEDDS as lipid nanocarriers for improving dissolution rate and bioavailability of poorly…
02. May 2018 An increase in the proportion of poorly aqueous soluble drugs that exhibit problems in oral bioavailability is one of the major problems in formulation…
The Preservation of Lyophilized Human Growth Hormone Activity: how Do Buffers and Sugars Interact?
02. May 2018
One of the most common classes of excipients used in protein formulations are buffers. The aim of this work is to investigate the effect of buffers on protein stabilization given by sugars during freeze drying.…
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano-polyplexes
02. May 2018
Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide-polymer nano-polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously-described…
Comparative analyses of flow and compaction properties of diverse mannitol and lactose grades
02. May 2018 Appropriate selection of excipient grade during tablet formulation development depends on thorough knowledge in their compaction and flow properties. Each…
Top Pharma Deals in March 2018
02. May 2018 If the first two months of 2018 saw pharma and biotech firms receive more money than what all biotech companies raised throughout 2013, March witnessed the…
Downstream processing of a ternary amorphous solid dispersion
01. May 2018 Downstream processing aspects of a stable form of amorphous itraconazole exhibiting enhanced dissolution properties were studied. Preparation of this ternary…
A novel approach to support formulation design on twin screw wet granulation technology:…
The overall objective of this work is to understand how excipient characteristics influence the drug product quality attributes and process performance of a continuous twin screw wet granulation process. The knowledge gained in this study…
Roll Compaction and Tableting of High Loaded Metformin Formulations Using Efficient Binders
30. April 2018
Metformin has a poor tabletability and flowability. Therefore, metformin is typically wet granulated with a binder before tableting. To save production costs, it would be desirable to implement a roll…
CLEAN LABEL LUBRICANT: Replace magnesium stearate with a tailored tableting compound
30. April 2018 Sponsored Content There is a demand in the market to exchange Magnesium Stearate with a Clean Label Lubricant for use in tableting and…
Regulatory pitfalls and opportunities when repurposing for inhalation therapy
27. April 2018 This article reviews regulatory considerations for companies wishing to develop drugs for delivery via the respiratory tract (e.g., by oral inhalation or…
Thiolated Polymers: Pharmaceutical Tool in Nasal Drug Delivery of Proteins and Peptides
27. April 2018 Although bioavailability of peptides administered through nasal route is still under 1% because of low membrane permeability, a short local residence time and a…
Obtaining Generic Drug Approval in the United States
27. April 2018 "This article is copyright by DrugPatentWatch and was originally published…
An animal’s sex influences the effects of the excipient PEG 400 on the intestinal P-gp protein…
27. April 2018 There is a growing body of evidence which suggests that formerly regarded “inert” pharmaceutical excipients have the potential to influence oral drug…