Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Enhanced excipients, additives and APIs
26. April 2018
Are you a manufacturer of raw materials for the food, nutraceutical or pharmaceutical industry and interested to increase your product performance or functionality? Are topics like
Dust free…
An Elemental Impurities Excipient Database: A Viable Tool for ICH Q3D Drug Product Risk Assessment
25. April 2018 To support the practical implementation of the ICH Q3D guideline, which describes a risk-based approach to the control of elemental impurities in drug products, a…
Nanocrystals for improved dermal drug delivery
25. April 2018 Nanocrystals are composed of 100% active and possess an increased aqueous solubility and dissolution velocity when compared to larger sized materials.…
Solubility and bioavailability improvement of pazopanib hydrochloride
25. April 2018 Theanti-cancer drug pazopanib hydrochloride (PZH) has a very low aqueous solubility and a variable oral bioavailability. A new pharmaceutical formulation with an…
Lipid-coated mannitol core microparticles for sustained release of protein
25. April 2018 Parenteral sustained release systems for proteins which provide therapeutic levels over a longer period avoiding frequent administration, which preserve protein…
Impact of super-disintegrants and film thickness on disintegration time of strip films loaded with…
24. April 2018 Although strip films are a promising platform for delivery of poorly water-soluble drug particles via slurry casting, the effect of critical materials…
Multi-Purposable Filaments of HPMC for 3D Printing of Medications with Tailored Drug Release and…
24. April 2018 Three-dimensional printing (3DP), though developed for nonmedical applications and once regarded as futuristic only, has recently been deployed for the…
Influence of excipients on physical and aerosolization stability of spray dried high-dose powder…
23. April 2018 The aim of this study is to investigate the influence of excipients on physical and aerosolization stability of spray dried Ciprofloxacin dry powder inhaler…
Undesired co-amorphisation of indomethacin and arginine during combined storage at high humidity…
23. April 2018 The use of co-amorphous systems for solubility enhancement of poorly water-soluble drugs has recently gained interest in the field of pharmaceutical…
Gelucire: A versatile polymer for modified release drug delivery system
Poly ethylene glycol (PEG) ester surfactants are synthesized by reacting polyethylene glycol with fatty acid. The polyethylene glycol comprises the hydrophilic part of the surfactant and the fatty acid is the lipophilic part. By…
Silica-based nanoparticles as drug delivery systems: Chances and challenges
20. April 2018 Silica-based nanoparticles are used as excipients in pharmaceutical technology. Recently, mesoporous silica nanoparticles have emerged as drug delivery…
Tailored Film Coating
20. April 2018
Are you looking for a tailored film coating for your product?
pharmaexcipients offers the access to film coating experts to put together a tailored coating based on your application…
FILM COATING: Natural colored coating and TiO2-free!
Do you need a tablet film coating with natural colors and TiO2-free?
Pharmaexcipients.com offers the access to the film coating experts from BIOGRUND US, Sterling. VA. They put together a tailored ready to use coating based on your…
Top 10 Pharmaceutical Companies 2018
The Complete List and Analysis of the 10 Best Pharmaceutical Companies in 2018. 7 criteria have been considered including revenue, growth, R&D investments, and others.
The global pharmaceutical market was…
Magnesium stearate is an incompatible excipient for aspirin in wet granulation producing non-linear…
19. April 2018 Excipients are materials added along with therapeutic agents; and incompatibility between excipients and therapeutic agents affect the final outcome of the…
Drug permeability profiling using cell-free permeation tools: Overview and applications
19. April 2018 Cell-free permeation systems are gaining interest in drug discovery and development as tools to obtain a reliable prediction of passive intestinal absorption…
Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations
18. April 2018 Ball-milling is usually used to prepare co-amorphous drug–amino acid (AA) mixtures. In this study, co-amorphous drug–AA mixtures were produced using…
Dosage form modification and oral drug delivery in older people
18. April 2018 Many people cannot swallow whole tablets and capsules. The cause ranges from difficulties overriding the natural instinct to chew solids/foodstuff before…
3D printed, controlled release, tritherapeutic tablet matrix for advanced anti-HIV-1 drug delivery
18. April 2018 A 3D-Bioplotter® was employed to 3D print (3DP) a humic acid-polyquaternium 10 (HA-PQ10) controlled release fixed dose combination (FDC) tablet comprising of…
Certificates of Analysis: Don’t Trust, Verify
18. April 2018 Just found this article on pharmtech.com with the introduction "Taking vendor product data at face value puts pharmaceutical manufacturers and…
Preparation Method and Amorphous Systems
18. April 2018 A video explanation by Dr. Thomas Rades featured by Pharmatech and BASF. The preparation method is crucial in solid amorphous systems. “It really…
Taste masking made simple with Precirol® ATO 5 and a high shear mixer
17. April 2018
To circumvent the bad taste of drugs, many technologies are available, such as pro-drugs synthesis, formulating with flavors and sweeteners or coating drug particles with a lipid film. The versatility of the…
Surfactants as Stabilizers for Biopharmaceuticals
16. April 2018 Surfactants are common stabilizers, often added to biopharmaceuticals formulations, but the mechanisms at the basis of their activity are unclear. The aim of…
Tailoring supersaturation from amorphous solid dispersions
15. April 2018
The maximum achievable concentration of a drug in solution is dictated by the chemical potential of the solid form. Because an amorphous solid has a higher chemical potential than the…
Limitations of high dose carrier based formulations
15. April 2018 This study was performed to investigate how increasing the active pharmaceutical ingredient (API) content within a formulation affects the dispersion of…
Repurposing excipients as active inhalation agents: The mannitol story
14. April 2018 The story of how we came to use inhaled mannitol to diagnose asthma and to treat cystic fibrosis began when we were looking for a surrogate for exercise as a…
Consecutive Spray Drying to Produce Coated Dry Powder Vaccines Suitable for Oral Administration
13. April 2018 Current global vaccination programs are challenged by costs associated with vaccine cold chain storage and administration. A solid, thermally stable oral…
Polymeric materials for targeted delivery of bioactive agents and drugs – Chapter of…
13. April 2018 In recent years, the application of polymeric materials for a targeted drug-delivery system has been greatly advanced. Since polymeric materials played a…
Cross-sectional analysis of impregnated excipient particles by energy dispersive X-ray spectroscopy
13. April 2018 Impregnation of active pharmaceutical ingredients (APIs) onto porous excipients has numerous benefits for solid dosage formulations. Previous work has…
Amorphous-Amorphous Phase Separation in API/Polymer Formulations
12. April 2018 The long-term stability of pharmaceutical formulations of poorly-soluble drugs in polymers determines their bioavailability and therapeutic applicability.…
Influence of Low-Molecular-Weight Excipients on the Phase Behavior of PVPVA64 Amorphous Solid…
12. April 2018 PURPOSE: The oral bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved by the preparation of amorphous solid…
Nanocrystal cellulose as drug excipient in transdermal patch for wound healing: an overview
11. April 2018 Wound must be carefully treated to avoid serious infection that needs costly treatment. Method to enhance the recovery of the wound is crucial to have…
Microparticle preparation by a propylene carbonate emulsification-extraction method
11. April 2018 The use of various harmful organic solvents for microparticle formulations is still widespread. Here, an alternative low toxicity solvent (propylene…
Differences in properties of HPMC co-processed fillers prepared by fluid-bed coating and spray…
11. April 2018 This study aimed to develop novel co-processed tablet fillers based on the principle of particle engineering for direct compaction and to compare the…