Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Capsules Using Pelletization Technique
Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit…
Tablet ejection force and its sensitivity to lubrication for pharmaceutical powders
09. April 2018 Pharmaceutical powders can exhibit markedly different tablet ejection forces. The purpose of this study is to understand the factors leading to the…
Robust State Estimation of Feeding-Blending Systems in Continuous Pharmaceutical Manufacturing
09. April 2018 State estimation is a fundamental part of monitoring, control, and real-time optimization in continuous pharmaceutical manufacturing. For nonlinear dynamic…
PBP Worldmeeting in Granada – A summary video
09. April 2018 Some impressions of the 2018 PBP Worldmeeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology in…
Highlights of DDF Summit Berlin 2018
09. April 2018 Video with some great insights into the last edition of DDF Summit, March 12-14, 2018 in Berlin. Good mix of innovation of drug delivery and hot topics in the…
Improved properties of fine active pharmaceutical ingredient powder blends and tablets at high drug…
07. April 2018 It has been shown that dry coating cohesive active pharmaceutical ingredients (APIs) with nano-silica can improve packing and flow of their blends,…
Removing the Bitter Taste from Drug Development
06. April 2018 The development of effectively formulated oral drug products is key to ensuring patient compliance and desired clinical outcomes. Given the increasing…
1st Pharmaexcipients Poster Award
With this poster award we would like to increase the visibility of all the work put into preparation of posters for the different congresses, share this knowledge and award the 3 best posters. The winners will not chosen by a jury but by…
Drying of Biopharmaceuticals: Recent Developments, New Technologies and Future Direction
05. April 2018 The dehydration of biopharmaceutical products through drying provides numerous benefits, including ease of handling and storage, reduction in transportation…
Pharmaceutical 3D Printing: Design and Qualification of a Single Step Print and Fill Capsule
05. April 2018 Fused deposition modeling 3D printing (3DP) has a potential to change how we envision manufacturing in the pharmaceutical industry. A more common utilization…
Oral bioavailability enhancement of agomelatine by loading into nanostructured lipid carriers
04. April 2018 Agomelatine (AGM) is a new antidepressant drug with a novel mechanism of action and fewer side effects compared with older antidepressants. AGM is a melatonin…
Osmolality predictive models of different Polymers as tools in parenteral and ophthalmic formulation…
04. April 2018 During the development of parenteral dosage forms, different physicochemical studies are required to ensure stable, effective and safe formulations. The…
3D printing of wood-derived biopolymers: A review focused on biomedical applications
04. April 2018 Wood-derived biopolymers have attracted great attention over the past few decades due to their abundant and versatile properties. The well-separated three…
Granulation & Compression Workshop
04. April 2018 Granulation & Compression Workshop A full day of lectures on the Basics of Granulation, Wurster Coating, Tablet Compression, Tooling and Troubleshooting…
Drug patent expirations of 2018
04. April 2018
Drug patent expirations of 2018 - The Top 15
Article from Fierce Pharma by Eric Sagonowsky - April 3, 2018
Each year, dozens of branded pharmaceutical products lose their patent protections in a…
Streamlined Manufacture of Modified Release Matrix Tablets via Direct Compression
03. April 2018 Overview Webinar Title: Streamlined Manufacture of Modified Release Matrix Tablets via Direct Compression Date: Tuesday, April 10, 2018…
Protective effect of sodium stearate on the moisture-induced deterioration of hygroscopic…
01. April 2018 Amorphous powders are thermodynamically unstable, significantly impacting the processing, storage and performance of a product. Therefore, stabilization of…
Role of self-emulsifying drug delivery systems in optimizing the oral delivery of hydrophilic…
01. April 2018 Self-emulsifying drug delivery systems (SEDDS) have been widely employed to improve the oral bioavailability of poorly soluble drugs. In the past few years,…
Flow, compaction and tabletting properties of co-processed excipients using pregelatinized Ofada…
31. March 2018 The growing popularity of direct-compression process necessitates an ideal filler–binder that can substitute two or more excipients. Pregelatinization of…
Can Early Development Strategies avoid later Disasters?
31. March 2018 By Rita C. Peters - Pharmaceutical Technology - Volume 42, Issue 3, pg 18–21 While some drug innovations are the result of surprises…
Control Strategy Considerations for Continuous Manufacturing Using Hot Melt Extrusion
31. March 2018 Just found this chapter of the 2nd Edition of "Pharmaceutical Extrusion Technology" which can be of interest in the field of continuous manufacturing.…
Top drugs by sales in 2017 – what happens this year?
30. March 2018 The year 2017 was a landmark year for pharmaceutical industries in the US and Europe, with a sharp increase in the number of new molecular entities (NMEs)…
In situ self-assembly nanoparticles for Oral Docetaxel
29. March 2018
Docetaxel (DTX) is a chemotherapy drug that can be used for different type of cancers. Due to polysorbate 80, the excipient in the formulation, acute hypertensivity reaction is observed after intravenous…
Consideration of the solid state for resveratrol nanocrystal production
28. March 2018 Production of nanosuspension for drug bioavailability improvement has been accepted and frequently used in pharmaceutical industry. Normally, the preparation…
Analysis of a Mini-tablet Fluidized Bed Coating Process
28. March 2018 Mini-tablets with diameters of 2.0, 2.5, and 3.0 mm are coated in two different lab-scale fluidized bed coaters equipped with a Wurster draft tube. The main…
Twin screw granulation: An evaluation of using micronized lactose as a solid binder
28. March 2018 In twin screw wet granulation process, the binding excipients could be added in two ways: premixed with powder materials…
Dry Particle Coating – An interesting approach
27. March 2018 Particle surface modification is becoming a vital strategy in the pharmaceutical industry for “difficult to formulate” APIs. Most surface modification…
Comparison of melibiose and trehalose as stabilising excipients for spray-dried β-galactosidase…
26. March 2018
Spray-dried protein formulations commonly require stabilising excipients to prevent protein degradation during processing and storage, and trehalose has been commonly used. The purpose of this workwas to…
Synergistic effect of PLGA nanoparticles and submicron triglyceride droplets in enhancing the…
26. March 2018 A novel hybrid microparticulate system composed of poly(lactic-co-glycolic) acid (PLGA) nanoparticles and submicron medium-chaintriglyceride (MCT) droplets was…
Variability in Excipients: Tylose in Microcrystalline Cellulose
26. March 2018 Compatibility of excipients in drug products is demonstrated in accelerated and real-time stability programs, but too often batch-to-batch variability of…
Top 25 global pharma companies by market cap
26. March 2018 The completed analysis, performed by GlobalData, a data and analytics company, reveals a number of interesting insights. The pharma sector’s 2017 v 2016…
Hydrogels as intelligent materials: A brief review of synthesis, properties and applications
25. March 2018 Hydrogels are a unique class of three dimensional cross-linked polymeric networks that can hold a large fraction of aqueous solvents and biological fluids within…
Modeling the Effects of Material Properties on Tablet Compaction
25. March 2018 Modeling the Effects of Material Properties on Tablet Compaction: A building block for controlling both batch and continuous pharmaceutical manufacturing proces As…
Tablet fragmentation without a disintegrant: A novel design approach
25. March 2018 Fused deposition modelling (FDM) 3D printing has shown the most immediate potential for on-demand dose personalisation to suit particular patient's needs.…
IPEC and PDA team on excipient risk assessment guidance
23. March 2018
IPEC Federation and PDA will publish a technical report in 2019 to provide drugmakers guidelines on how to implement risk assessment challenges of excipient supply.
See our…