Recent advances in polymer-based nanoformulations for enhancing oral drug delivery in diabetes
Diabetes is a long-term metabolic disorder caused by issues with insulin production or response in the body. This leads to high levels of glucose in the blood, which can cause other health problems. People with diabetes are advised to eat healthily and stay active to manage their blood sugar levels. However, if these lifestyle changes aren't…
Pharma 4.0 & Smart Patient Reported Outcomes
08. March 2018
Pharma 4.0 & Smart Patient Reported Outcomes
connecting biology, physics and digital for the benefit of human wellbeing.
If you look over your shoulder you can connect the dots. If you look at…
Stability of 5 mg/mL Pediatric Prednisone Oral Suspension in Syrspend® SF PH4
08. March 2018 Background Prednisone is a corticosteroid used in several inflammatory diseases and cancers. In France, no available prednisone drinkable formulation…
Starch-Chitosan Polyplexes: A Versatile Carrier System for Anti-Infectives and Gene Delivery
08. March 2018 Despite the enormous potential of nanomedicine, the search for materials from renewable resources that balance bio-medical requirements and engineering…
Sodium stearate for moisture protection of hygroscopic spray-dried powders
06. March 2018 Abstract Amorphous powders are thermodynamically unstable, significantly impacting the processing, storage and performance of a product. Therefore,…
Continuous direct compression as manufacturing platform for sustained release tablets
05. March 2018 Abstract This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging…
Brain targeting of resveratrol by nasal administration of chitosan-coated lipid microparticles
05. March 2018 Abstract Lipid microparticles (LMs) uncoated or coated with chitosan and containing the neuroprotective polyphenol, resveratrol were developed for its…
Zero-order release of poorly water-soluble drug from polymeric films made via aqueous slurry casting
05. March 2018 Abstract In spite of significant recent interest in polymeric films containing poorly water-soluble drugs, dissolution mechanism of thicker films has not…
Continuous Manufacturing “Extra Small” with MODCOS XS
05. March 2018 Are you ready to start your continuous process in the smallest lab scale? Is API availability a topic? Our new MODCOS XS allows…
The relationship among tensile strength, Young’s modulus, and indentation hardness of…
05. March 2018 Abstract Mechanical properties of pharmaceutical materials, e.g., Young's modulus (E), indentation hardness (H), and tensile strength (σ), play an…
Fluid bed rotor granulator: Formulate a poorly water-soluble drug in SR hollow granules with a…
05. March 2018 Abstract Water-soluble polymers with high viscosity are frequently used in the design of sustained-release formulations of poorly water-soluble drugs to…
Pellets: Multiparticulate drug formulations are on the rise
04. March 2018 Owing to the many benefits they offer both manufacturers and patients, the use of pellets in drug formulation has gained popularity in recent years. …
Pharma Deals, Investments and M&As in January 2018
03. March 2018 Pharma Deals, Investments and M&As in January 2018 Big bang M&As: Sanofi acquires Bioverativ, Ablynx; Celgene acquires Juno Therapeutics The year…
Lyophilization model of mannitol water solution in a laboratory scale lyophilizer
03. March 2018 Abstract The paper reports on the development of a numerical model for the simulation of a lyophilization process in a vial. Experimental analysis is…
Polymer adhesion predictions for oral dosage forms to enhance drug administration safety
02. March 2018 Abstract The oral cavity is frequently used to administer pharmaceutical drug products. This route of administration is seen as the most accessible for the…
Mechanism-based modeling of biological processes involved in oral absorption
02. March 2018 Abstract For orally administered drugs, the rate and extent of absorption are governed by the physiology of the gastrointestinal tract, the characteristics…
Patient focused design and development of an age-appropriate paediatric formulation
02. March 2018 Introduction: The selection and design of dosage form for the paediatric population is a real challenge. Part of that challenge is to deal with the diversity…
Monitoring of Multiple Solvent Induced Form Changes during High Shear Wet Granulation and Drying…
01. March 2018 Abstract Form changes during drug product processing can be a risk to the final product quality in terms of chemical stability and bioavailability. In this…
Ideal Cures: Proud Platinum Sponsors of the 16th International Symposium organised by Controlled…
01. March 2018 February 23-24 2018, Mumbai Team Ideal Cures presented three posters at the 16th International Symposium organised by Controlled Release Society…
Polyfunctional Siloxane Water-Soluble Nanoparticles for Biomedical Applications
01. March 2018 Most of antibacterial and antiviral agents and drugs for the treatment of central nervous system and cancer are water-insoluble, which reduces their…
Adhesives: Applications and Recent Advances
27. February 2018 Abstract Adhesives can be defined as social substances capable to join permanently to surfaces, by an adhesive process. This process involves two…
Medicated Straws Based on Electrospun Solid Dispersions
27. February 2018 Novel medicated straws were developed based on drug-loaded electrospun fibers prepared by direct current electrospinning (DCES) and high-speed…
Permeability and the Performance of Carrier-Based Dry Powder Inhalation Mixtures
26. February 2018 The permeability of a powder bed reflects its particle size distribution, shape, packing, porosity, cohesivity, and tensile strength in a manner relevant…
Systematic evaluation of common lubricants for optimal use in tablet formulation
26. February 2018 As an essential formulation component for large-scale tablet manufacturing, the lubricant preserves tooling by reducing die-wall friction. Unfortunately,…
Cyclodextrins for parenteral use
26. February 2018 A comparison of Hydroxypropyl and Sulfobutyl Betadex As a result of thorough development work, CycloLab Ltd (Budapest, Hungary) has established and…
Influence of excipients – the unique deleterious effects of magnesium stearate
26. February 2018 Original Title: "Formulating Weakly Basic Hal Salts: Relative Ability of Common Excipients to Induce Disproportionation and the Unique…
Flexible and precise dosing of enalapril maleate for all paediatric age groups utilizing…
24. February 2018 Enalapril is an off-patent angiotensin-converting enzyme inhibitor for which no paediatric age-appropriate formulation is commercially available in Europe, and…
Solid-State NMR Investigation of Drug-Excipient Interactions and Phase Behavior in…
24. February 2018 To investigate the nature of drug-excipient interactions between indomethacin (IMC) and methacrylate copolymer Eudragit® E (EE) in the…
Incomplete copolymer degradation of in situ chemotherapy
23. February 2018 In situ carmustine wafers containing 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) are commonly used for the treatment of recurrent glioblastoma to overcome…
The development of zirconia/silica hybrids for the adsorption and controlled release of APIs
23. February 2018 The study concerns the synthesis and application of a novel type of ZrO2-SiO2 binary oxide system. The material was prepared via a sol-gel route, using…
Special Application Systems with Phospholipids
23. February 2018 SOLUTHIN® MD H: A fast-dispersible hydrogenated phospholipid formulation increasing the dissolution of poorly soluble actives in water …
Nano gels for applications in 3D Printing Technologies
23. February 2018 Nanogels are hydrogels formed by connecting nanoscopic micelles dispersed in an aqueous medium, which give an opportunity for incorporating hydrophilic…
Excipient online samples – the easy way
23. February 2018
A short video about online excipient samples by pharmaexcipients.com. We offer direct sample ordering of listed excipients or support the search for a excipient supplier.…
Solid state characterisation and taste masking efficiency evaluation of polymer based extrudates of…
22. February 2018 Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to investigate…
Food effects in paediatric medicines development for products Co-administered with food
22. February 2018 A small amount of food is commonly used to aid administration of medicines to children to improve palatability and/or swallowability. However the impact of…