Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Insights on thermoreversible properties of Pluronic® tri-block copolymers
03. January 2018 Abstract This investigation presents a study on the effect of various polymers on gelling properties of tri-block (Pluronic®) copolymers and increasing…
Aqueous solubility-enhancing excipient technologies – Latest Developments
03. January 2018 At least some degree of solubility in water is necessary for active ingredients in pharmaceutical products to be effective in vivo. However, as efforts to…
Learn more about natural gums and mucilage used as excipients
02. January 2018 Abstract Natural mucilage’s are included in novel drug delivered (NDDS) to multitask functions and in any cases directly or indirectly control the…
A Happy New Year from pharmaexcipients.com !
01. January 2018 We wish you and your dear ones a healthy, happy and successful 2018! Of course we also look forward to share and exchange with you…
Modified release formulations give new life to drugs
31. December 2017
Both pharmacological and economic factors drive the decision to use these technologies.
This article by Peggy Wright published in Pharmaceutical Commerce in 2014 describes the potential of…
HPMCAS as an effective precipitation inhibitor in amorphous solid dispersions of the poorly soluble…
30. December 2017 Abstract Among the strategies to improve the biopharmaceutic properties of poorly soluble drugs, Supersaturating Drug Delivery Systems like…
Lubricant based determination of design space for continuously manufactured high dose paracetamol…
30. December 2017 Abstract The objective of this study was to devise robust and stable continuous manufacturing process settings, by exploring the design space after an…
Novel adhesive hyaluronic acid based solid dosage form for pediatric application
27. December 2017 Abstract The aim of this study was to develop a solid dosage form for pediatric application. For this purpose, hyaluronic acid was covalently linked…
THE EXCIPIENTEERS and their Super Powers!
27. December 2017 A Fun IMCD US Pharma Holiday Card 2017 - Featuring THE EXCIPIENTEERS and their Super Powers! …
Drug Discovery, Development and Deployment Maps
The Drug Discovery, Development and Deployment Maps (4DM) provide dynamic representations of the modern therapeutic development process to more easily identify inefficiencies and integrate efforts to expedite new therapies for…
Lactose oleate as new biocompatible surfactant for pharmaceutical applications
26. December 2017 Abstract Sugar fatty acid esters are an interesting class of non-ionic, biocompatible and biodegradable sugar-based surfactants, recently emerged as a…
Polymer-amino-functionalized silica composites for the sustained-release multiparticulate system
26. December 2017 Abstract This study presents an interesting and promising strategy for producing an oral multiparticulate formulation of the sustained-release of…
Eudragit S100 Coated Microsponges for Colon Targeting of Prednisolone
26. December 2017 Context: Microsponge is a novel approach for targeting the drug to the colon for the management of colon ailments such as inflammatory bowel disease.…
Novel enzyme formulations for improved pharmacokinetic properties and anti-inflammatory efficacies
25. December 2017 Abstract Anti-inflammatory enzymes promote the dissolution and excretion of sticky phlegm, clean the wound surface and accelerate drug diffusion to the…
Drug nanocrystals – Versatile option for formulation of poorly soluble materials
25. December 2017 Abstract Poor solubility of drug compounds is a great issue in drug industry today and decreasing particle size is one efficient and simple way to…
Physical Stability of API/Polymer-Blend Amorphous Solid Dispersions
24. December 2017 The preparation of amorphous solid dispersions (ASDs) is a well-established strategy for formulating active pharmaceutical ingredients by embedding them in…
Milling induced amorphisation and recrystallization of α-lactose monohydrate
24. December 2017 Preprocessing of pharmaceutical powders is a common procedure to condition the materials for a better manufacturing performance. However, such operations…
Novel spray-dried lactose-leucine tailored to enhance the aerosolization performance in DPI…
24. December 2017 Abstract Spray-drying allows to modify the physicochemical/mechanical properties of particles along with their morphology. In the present study,…
Oral Biopharmaceutics Tools: What is New and What is Coming?
24. December 2017 APV/FIP Joint-Workshop in Nuremberg Greifswald, Germany Dissolution testing is an important tool from early development to life cycle management of a…
Size and Taste Matters: Recent Progress in the Development of Age-Appropriate Medicines for Children
24. December 2017 Drug therapy for children is one of the cornerstone developments that have sharply reduced childhood mortality. Despite this, many challenges remain in…
Getting more out of Silica – a Video explanation by Grace
22. December 2017
Grace’s SILSOL® technology offers solutions for poorly soluble active ingredients. Based on compendial silica and fully scalable, it gives pharmaceutical developers new…
Analysis of a continuous twin-screw melt granulation process using polymeric binders
21. December 2017 The concept of twin-screw melt granulation (TSMG) has steadily (re)-gained interest in pharmaceutical formulation development as an intermediate step…
Top Pharmadeals in November – Mergers & Acquisitions
21. December 2017 Top Pharmadeals in November - Mergers & Acquisitions The deals last month revolved around breakthrough cancer research and drug discovery, and new…
Mechanism of Magnesium Stearate to Modify Aerosol Performance in DPI Formulations
20. December 2017 Abstract The potential of the force control agent (FCA) magnesium stearate (MgSt) to enhance the aerosol performance of lactose-based dry powder inhaled…
Transdermal Delivery of Ibuprofen Utilizing a Novel Solvent-Free Technology
20. December 2017 Purpose The main objective of this present study was the investigation of potential novel transdermal patch technology (TEPI®) delivering ibuprofen as…
Anaphylaxis and the inclusion of polysorbates in biotherapeutics
20. December 2017
The formulation and manufacturing of parenteral biotherapeutic products occur at the interface of science and regulatory concerns. Science dictates the formulation composition, often including the addition…
Production of Cocrystals in an Excipient Matrix by Spray Drying
18. December 2017 Abstract Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of…
Correlation of dissolution and disintegration results for an IR tablet
18. December 2017 Abstract The drug release rate of a rapidly dissolving immediate-release tablet formulation with a highly soluble drug is proposed to be controlled by…
Polymeric gels for intravaginal drug delivery
15. December 2017 Abstract Intravaginal drug delivery can elicit a local effect, or deliver drugs systemically without hepatic first pass metabolism. There are a number…
Evaluation of predictive computational modelling in biologic formulation development
15. December 2017 Abstract Computational modelling has completely redefined the experimentation process in many industries, allowing large sets of design…
Pharma Deals, Investments and M&As in October 2017
15. December 2017 Pharma Deals, Investments and M&As in October 2017 Generic drug makers continue to drive deal making While debt-laden Teva led the deals in September…
Excipient Selection for Foams
15. December 2017 With air as another phase, foams have their unique set of challenges – but also offer opportunities. Learn why looking at the end-formulation and…
Sensory Quality and Excipients Choice
15. December 2017 Formulators usually face three kinds of challenges while addressing sensory quality. Firstly, when existing products are changed, the sensory properties…
The four pillars of Skin Delivery
15. December 2017 The four pillars of Skin Delivery are a result of continuous conversation with the marketplace and our customers: Dermal drug delivery, Mildness, Sensory…