Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
3D printed devices in the gastrointestinal tract of rodents – imaging by PET/CT
04. December 2017
Abstract
Fused deposition modelling (FDM) 3D printing (3DP) is a revolutionary technology with the potential to transform drug product design in both the pre-clinical and clinical arena. The objective…
Inkjet printing of oral dosage forms increasing the solubility of BCS Class II drugs
04. December 2017 Abstract Oral drug delivery remains the preferred method of administration but BCS Class II drugs are not ideally suited to this due to their inherent…
Arginine as an Excipient for Protein Freeze-Drying
03. December 2017 Abstract Successful development of marketable freeze-dried protein formulations requires adequate stabilization of the active biopharmaceutical…
Surface engineered excipients: Improved functional properties of fine grade microcrystalline…
03. December 2017
Abstract
Excipients with good flowability, bulk density as well as compaction properties are desired for use in tableting since they play important roles in formulation development and…
Formulation of a microemulsion-based hydrogel containing celecoxib
03. December 2017
The aims of this study are to prepare and characterize a microemulsion-based hydrogel containing celecoxib (CLX) for transdermal delivery. Pseudo-ternary phase diagrams containing 0.74% (w/w) CLX were…
Excipients and their Effects on the Quality of Small Molecules
01. December 2017 Video from the DDF Summit Excipient Session from March 2017 by Dr. Dave Elder. Interest in…
Cyclodextrin solubilization of celecoxib: solid and solution state characterization
01. December 2017 The low aqueous solubility of celecoxib (CCB) hampers its oral bioavailability and permeation from aqueous environment through biological membranes. The…
Ideal Cures wins India Pharma Award with Instacoat 4G
30. November 2017 Instacoat 4G wins in the category Excellence in R&D - Development of new product / techology. “INSTACOAT 4G is a new generation Immediate…
Drug-excipient compatibility assessment of solid formulations containing meloxicam
29. November 2017 Meloxicam (MLX) is a non-steroidal anti-inflammatory cyclooxygenase (COX) inhibitor that is used to relieve inflammation and pain. MLX has a preferential…
Unexpected solubility enhancement of drug bases in presence of a dimethylaminoethyl methacrylate…
29. November 2017 The methacrylate-copolymer Eudragit® EPO (EPO) has previously shown to greatly enhance solubilization of acidic drugs via ionic interactions and by multiple…
Fractal Aspects of Static and Dynamic Flow Properties of Pharmaceutical Excipients
29. November 2017 Purpose Characterisation of powder flow is important for pharmaceutical processing and manufacturing. This work aims at a…
Incorporation of surface-modified dry micronized poorly water-soluble drug powders into polymer…
28. November 2017 Recent work has established polymer strip films as a robust platform for delivery of poorly water-soluble drugs via slurry casting, in particular using stable…
Particle design via spherical agglomeration
28. November 2017 Particle design via spherical agglomeration is a size enlargement technique used in various bulk and fine chemical industries, with recent interest…
Enhancement of solubility and oral bioavailability of poorly soluble drugs – A Review
27. November 2017 Abstract Drug solubility can pose a great challenge for the development of novel formulations and impacts a wide spectrum of drugs with poor…
Development of sustained-release lipophilic calcium stearate pellets via hot melt extrusion
26. November 2017 Abstract The objective of this study was the development of retarded release pellets using vegetable calcium stearate (CaSt) as a thermoplastic…
Relative Densities of Powders, Blends, Dry Granulations, and IR Tablets
26. November 2017 The absolute and relative densities of pharmaceutical solids play an important role in determining their performance (e.g., flow and…
HPMC granules by wet granulation process: Effect of vitamin load
25. November 2017 Abstract Due to its versatile properties, hydroxypropyl methylcellulose (HPMC) is largely used in many applications and deeply studied in the various…
Particle agglomeration of chitosan–magnesium aluminum silicate nanocomposites for direct compression…
25. November 2017 Abstract Exfoliated nanocomposites of chitosan-magnesium aluminum silicate (CS-MAS) particles are characterized by good compressibility but poor…
Alfuzosin Hydrochloride ODTs with Risk Evaluation via Quality by Design
25. November 2017 In this study, within the framework of Quality by Design which is a systematically scientific approach which enables to understand and control the…
Hydroxypropylcellulose as matrix carrier for novel cage-like microparticles prepared by…
24. October 2016 Abstract The objective of this study is to design novel dissolution-enhanced microparticles loaded poorly soluble drug nanocrystals used a low viscosity…
PLGA-based monolithic filaments prepared by hot-melt extrusion
24. November 2017 To avoid frequent drug administration, PLGA-based monolithic filament-shaped implants were prepared. In this study, the effect of different formulation…
Alpha tocopherol loaded chitosan oleate nanoemulsions for wound healing
24. November 2017 An amphiphilic chitosan salt, chitosan oleate (CS-OA), was previously proposed for the physical stabilization of lemongrass antimicrobial nanoemulsions…
Outsourcing Strategies:The Evolving role of CDMOs
24. November 2017
How can CDMOs play a better, more strategic role in the greater pharma supply chain and better serve their customers?
Instead of relying on organic market growth alone to propel revenue and…
Reprecipitation of poorly water-soluble cilostazol crystals using adsorbing carriers
24. November 2017 Abstract The aim of this new work was to improve the dissolution rate of poorly water-soluble cilostazol (CLT) by adsorbing dissolved drug molecules…
Alternative Technologies to Improve Solubility and Stability of Poorly Water-Soluble Drugs
23. November 2017 The solubility behavior of drugs remains one of the most challenging aspects in formulation development. Solid dispersions (SD) and inclusion complexes…
Amorphous solid dispersions of hecogenin acetate using different polymers
23. November 2017 Abstract Hecogenin acetate (HA) is an acetylated sapogenin that has shown potential antihyperalgesic activity, inhibiting descending pain and acting in…
Pellets loaded with nano emulsions for oral drug delivery
23. November 2017 The dissolution rate of the Biopharmaceutical Classification System (BSC) Class II compounds (low water solubility and high permeability) is one of the…
Role of Excipients in formulation development and biocompatibility of lipid nanoparticles – a…
22. November 2017 Lipid nanoparticles are widely explored in many therapeutic, targeting, and imaging areas. Among the various nanoplatforms, lipid-based nanostructures…
Diversity and Functionality of Excipients for Micro/Nanosized Drug Carriers – a book chapter
22. November 2017 Continuous efforts to improve performance of drugs via incorporation in particulate and soft colloidal carriers have introduced new functional categories…
Multiple-Unit Pellet Systems: Production and Applications as Advanced Drug Delivery Systems
22. November 2017 Background and Objective: Single-unit solid oral dosage forms such as tablets and capsules are considered the most common and acceptable form of immediate…
EXCiPACT announces the publication of their 2017 Certification Standards for Pharmaceutical…
22. November 2017 The 2017 Standards reflect the changes in the ISO 9001:2015 and ISO/IEC 17021-1:2015 Standards. The EXCiPACT Certification Scheme…
Excipient exposure in very low birth weight preterm neonates
21. November 2017 Objective: The excipients benzyl alcohol, propylene glycol and ethanol are present in medications used in the neonatal intensive care unit. Exposure to…
Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using PAT
21. November 2017 Process Analytical Technology, or “PAT” is the term given to analytical instruments developed to measure certain attributes of product within the…
Europe in the Lead with Continuous Manufacturing
20. November 2017 Continuous manufacturing is increasing rapidly in Europe’s pharmaceuticals sector after expanding only slowly for several years. In 2016, Europe had—at…