Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
The value of pharmaceutical excipients – an IPEC Europe Information
27. October 2017
IPEC Europe has published an informative overview on the value of excipients in the pharmaceutical industry, in medicines and finally for the patients.
The Value of Pharmaceutical…
Properties of Water Bound in Hydrogels
27. October 2017 Abstract: In this review, the importance of water in hydrogel (HG) properties and structure is analyzed. A variety of methods such as 1H NMR (nuclear…
Evaluation of Chitosan and Cellulosic Polymers as Binding Adsorbent Materials for Mycotoxins
26. October 2017 Mycotoxins are secondary toxic metabolites that are produced by fungi representing threats to human and animal health. The objective of this study was to…
Complex Interplay Between Solubilization, Digestion, Supersaturation and Absorption of Poorly…
26. October 2017 Lipid-based formulations (LBFs) can be effective oral drug delivery systems for poorly water-soluble chemical entities, provided they are designed with careful…
Carbopol coated maize starch: A novel multifunctional excipient
25. October 2017 The aim of this study was to enhance the classical adjuvant functionality of maize starch (Mst) by co-processing with small quantities of carbopol 974P…
Coating of finely dispersed particles (<50 micron)
25. October 2017 Particle coatings are used extensively to generate dispersed solids with well-defined properties, e.g., to protect active ingredients, with most coating…
improvement of fine powders through nano-coating
25. October 2017
Majority of the pharmaceutical dosage forms are manufactured from powders as a starting material. The handling and processing problems in pharmaceutical manufacturing still revolves around unpredictable…
A non-destructive method for the pellet distribution analysis within a MUPS tablets
25. October 2017 Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different…
CPhI Worldwide starts today – have a great show!
24. October 2017 Today CPhI worldwide is opening the doors to about 40.000 visitors from the pharmaceutical industry. It is the event for pharmaceutical excipient…
Mechanical properties of compacted paraffin powders. Effect of formulation
24. October 2017 The mechanical characteristics of a paraffin–vegetable oil material and the compressive behavior of the powder stemming from this material were used to…
Development of a Starch-Based Co-processed Excipient for Direct Compression applying DoE
23. October 2017 The development of novel excipients with enhanced functionality has been explored using particle engineering by co-processing. The aim of this study was to…
An in vitro experiment to simulate swallowability of tablets
23. October 2017 The compliance of patients to solid oral dosage forms is heavily conditioned by the perceived ease of swallowing, especially in geriatric and pediatric…
Effect of Alcoholic Beverages on Drug Absorption
23. October 2017 Abstract Consumption of alcohol concomitantly with a drug may increase absorption of the active ingredients, leading to dose dumping. In this study,…
Enablement of the direct analysis of excipients in monoclonal antibody formulations
22. October 2017 Establishing and maintaining the correct formulation composition is essential for ensuring the stability of biopharmaceutical drug products. A barrier to…
Fast disintegrating tablet of Valsartan for the treatment of pediatric hypertension
21. October 2017 Fast disintegrating tablets (FDTs) dissolve or disintegrate in the mouth without the need of additional water. The aim of the present study was to formulate…
Poly(amidoamine) (PAMAM) dendrimers as a pharmaceutical excipient?
20. October 2017 Drug solubility could affect the therapeutic use of a drug because the biological activity of a drug is only possible if some fraction of a dissolved drug…
Are Lipid-Based Drug Delivery Systems in Your Formulation Toolbox?
20. October 2017
This article reviews the causes of poor bioavailability for drugs. It provides an introduction to lipid-based drug delivery systems, and how the formulation approach can be used to overcome…
Neue Vorgaben für problematische Hilfsstoffe
19. October 2017
Die Europäische Arzneimittelagentur (EMA) und die Europäische Kommission haben die Liste von Hilfsstoffen überarbeitet, die vorgibt, welche Stoffe die Pharmaunternehmen unter welchen Bedingungen auf der…
Age-appropriate formulations including pharmaceutical excipients in neonatal medicines.
19. October 2017 BACKGROUND: The development of appropriate pharmaceutical formulations for routine neonatal practice is challenging because of the developmental…
Porous silica to provide on-dose product identification and to improve patient compliance
19. October 2017 Silica is well known in the pharmaceutical industry as an excipient. While pure silica, SiO2, is common, there are silicates of calcium,…
Role of Excipients – comment of CPhI expert Brian Carlin
19. October 2017 Pharma companies are responsible for excipient quality, but they face challenges, including quality and a regulatory environment that discourages…
Dow highlights solutions for the toughest formulations and applications @CPhI
19. October 2017
MIDLAND, Mich - October 18, 2017 - With decades of technical and industry expertise, Dow Pharma Solutions – a business unit of the DowDuPont Specialty Products Division – addresses the toughest challenges…
Effects of solid vs. liquid dosage forms on adherence and acceptability in children
18. October 2017 Abstract This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effects of solid versus liquid dosage…
3D printed multi-compartment capsular devices for two-pulse oral drug delivery
18. October 2017 In the drug delivery area, versatile therapeutic systems intended to yield customized combinations of drugs, drug doses and release kinetics have drawn…
Grace licenses Formac’s bioavailability enhancement tech
18. October 2017
WR Grace & Co has licensed rights to a bioavailability enhancement technology from Formac Pharmaceuticals NV.
Excipients and Drug Delivery
Syloid® silica excipients are the…
Predicting solubility/miscibility in amorphous dispersions
18. October 2017 The evolving challenges associated with the development of poorly soluble drug molecules have been met with major advances in drug solubilization.…
Self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor®…
18. October 2017
The development of self-nanoemulsifying drug delivery systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs, is usually based on traditional one-factor-at-a-time approaches. These…
Outsourcing Strategies: The Evolving Role of CDMOs
18. October 2017
How can CDMOs play a better, more strategic role in the greater pharma supply chain and better serve their customers?
Instead of relying on organic market growth alone to propel revenue and profitability,…
S-protected chitosan: A promising mucoadhesive excipient for metronidazole vaginal tablets
17. October 2017 Aim Synthesis and evaluation of an entirely S-protected chitosan as mucoadhesive excipient for vaginal drug delivery. Methods N-acetyl-cysteine was…
Comparative disintegrant action study using Kohonen’s self-organizing maps
17. October 2017 To gain a better understanding of disintegration actions, 11 different disintegrants were tested. Model tablets were prepared with various preparation…
Excipients Insight October 2017 – IPEC Europe
17. October 2017
Our October edition of Excipients Insight is rather a bumper one! There’s a lot happening not least in the European regulatory environment, with seemingly many new revisions of legislation and guidance…
A NEW lactose grade available from ARMOR PHARMA !
17. October 2017
ARMOR PHARMA - the french manufacturer of pharmaceutical grade lactose - today announced the launching of a new lactose grade.
ARMOR PHARMA lactose monohydrate 350M :
ARMOR…
Dry powder inhaler for pulmonary drug delivery
17. October 2017
Pulmonary drug delivery is the promising delivery route to treat not only respiratory diseases but also systemic diseases and has proven as a potential delivery route for complex drugs that…
Fexofenadine hydrochloride orally disintegrating tablets for pediatric use
17. October 2017
Allergic rhinitis is a common disease in children which has considerable negative effects on the quality of life. Fexofenadine hydrochloride (FFH) is a second-generation oral antihistamine which has been…