Experimental Investigation on Efficacy of Eudragit RS 100 Polymer in Prolonging Glibenclamide Release by Intragastric Floating Microsphere Formulation and Physicochemical Evaluation
Abstract
Background: The amalgamation of targeted transportation and enhancement of the release profile of the active pharmaceutical ingredient is a contemporary trend in the evolution of oral medicinal products. A renowned method to actualize this concept is to develop floating gastroretentive delivery systems that ensure an extended stay of the…
Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route
Abstract
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid-induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of…
Drying liquids – Selecting the best technology for nutraceuticals
The desired end product properties can make a difference when choosing between spray drying or spray granulation
Both spray drying and fluid bed spray granulation can be used to convert liquid products into bulk materials. The most…
Virtually Possible: Enhancing Quality Control of 3D-Printed Medicines with Machine Vision Trained on…
Abstract
Three-dimensional (3D) printing is an advanced pharmaceutical manufacturing technology, and concerted efforts are underway to establish its applicability to various industries. However, for any technology to achieve widespread…
The Development of Oral Solid Dosage Forms Using the Direct-Compression Tableting of Spray-Dried…
Abstract
This study addresses the challenge of developing a cheap, patient-friendly alternative to antibiotics using bacteriophages for gastrointestinal applications. It explores the feasibility of manufacturing an enteric solid dosage…
Exploring the Potential of pH-Sensitive Polymers in Targeted Drug Delivery
The pH-sensitive polymers have attained significant attention in the arena of targeted drug delivery (TDD) because of their exceptional capability to respond to alteration in pH in various physiological environments. This attribute aids…
Optimisation of the Manufacturing Process of Organic-Solvent-Free Omeprazole Enteric Pellets for the…
Abstract
Liquid formulations are mostly used in the paediatric population. However, with certain active pharmaceutical ingredients (APIs), it is very difficult to guarantee quality and stability; this is the case, for example, with…
Determination of Gastric Water Emptying in Fasted and Fed State Conditions Using a…
Abstract
Because of the importance of gastric emptying for pharmacokinetics, numerous methods have been developed for its determination. One of the methods is the salivary tracer technique, which utilizes an ice capsule containing caffeine…
Suitability of Wurster-Fluid Bed technique for functional Eudragit L-100 coating on tablet cores
Introduction
Film coating of solid dosage forms in pharmaceutical manufacturing is carried out using range of equipment, process parameters and coating formulations to achieve the quality target profile of the dosage form. Besides for…
Exploring Applications of Plant-Derived Polymers in Fused Deposition Modeling of Oral Pharmaceutical…
Introduction
Additive manufacturing or 3D printing technology refers to the fabrication of three-dimensional objects from computer-aided designs (CAD) by adding layers of material on top of each other successively. In oral pharmacotherapy,…
Low drug load, high retention mometasone furoate cream with Polyglyceryl – 3 oleate as a…
In the present study, an oil-in-water (O/W) cream containing 0.05% mometasone furoate (MF) was prepared for the treatment of atopic dermatitis (AD) using Polyglyceryl-3 oleate (POCC) as a chemical enhancer. The cream formulation was…
Application on the Direct Encapsulation Method in the Technology of Medicine with Dry Rauwolphia…
Abstract
The aim: Development of the composition and technology of a medicinal drug in the form of capsules with a dry
extract of Rauwolfia for the treatment of hypertension.
Materials and methods: Experimental samples of masses for…
Comparison of Berberine Bioavailability between Oral and Rectal Administrations in Rats
Abstract
The oral bioavailability of berberine is quite low due to extensive first-pass metabolism. To increase the bioavailability of berberine (BBR), the efficacy of rectal administration that can avoid intestinal and hepatic first-pass…
Microemulsions: An Encapsulation Strategy to Increase the Thermal Stability of D-limonene
D-limonene, derived from citrus essential oils, holds significant therapeutic potential but faces challenges due to its high volatility, especially in pharmaceutical formulations. This study investigates microemulsions as a promising…
In Vivo Evaluation of a Gastro-Resistant Enprotect® Capsule under Postprandial Conditions
Ready-to-fill enteric hard capsule shells are an evolving field of oral drug and nutraceutical products. Lonza Capsugel® Enprotect® capsules were recently proven to provide reliable release in the small intestine after fasted intake, but…
Functionalized calcium carbonate (FCC) as a novel carrier to solidify supersaturated…
Abstract
Functionalized calcium carbonate (FCC), a novel pharmaceutical excipient, has shown promising properties in the field of oral drug delivery. The current study aimed at evaluating the feasibility of FCC as a carrier for the…
Exploring new ways to produce cosmetic pigments – Interview with Merck and Glatt about the…
Using completely new technology, pigment specialists at Merck and Glatt Ingenieurtechnik’s technology and production experts have worked closely together to produce an innovative range of cosmetic pigments. The Darmstadt-based Merck Group…
Smart pills and drug delivery devices enabling next generation oral dosage forms
Oral dosage forms are the preferred solution for systemic treatment and prevention of disease conditions. However, traditional dosage forms face challenges regarding treatment adherence and delivery of biologics. Oral therapies that require…
Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with…
This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the…
Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting…
Abstract
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control. Compared…
Roquette Introduced New Chapter in Moisture Protection at CPhI 2023
Press Release
La Madeleine (France), 25th October 2023 – Roquette, a global leader in plant-based ingredients and leading provider of pharmaceutical and nutraceutical excipients, is pleased to announce the addition of three new excipient…
Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and…
Abstract
We use dynamic micro-computed tomography (micro-CT) with a high temporal resolution to visualize water penetration through the porous network of immediate-release pharmaceutical solid tablets and characterize dynamic swelling and…
Optimizing environmental sustainability in pharmaceutical 3D printing through machine learning
Abstract
3D Printing (3DP) of pharmaceuticals could drastically transform the manufacturing of medicines and facilitate the widespread availability of personalised healthcare. However, with increasing awareness of the environmental damage…
MeltSerts Technology (Brinzolamide ocular inserts via hot-melt extrusion): QbD-steered development,…
The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. A 32 rotatable central…
Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs
Abstract
The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple…
Combining the potential of 3D printed buccal films and nanostructured lipid carriers for…
Abstract
Cannabidiol (CBD) has been recognized for its numerous therapeutic benefits, such as neuroprotection, anti-inflammatory effects, and cardioprotection. However, CBD has some limitations, including unpredictable pharmacokinetics and…
Self-emulsifying micelles as a drug nanocarrier system for itraconazole oral bioavailability…
Abstract
Itraconazole (ITZ) is a renowned antifungal medication, however its therapeutic efficacy is limited by low solubility and oral bioavailability. The current research work attempted to augment the oral bioavailability of ITZ by…
A toolbox for mimicking gastrointestinal conditions in children: Design and evaluation of…
Abstract
The goal of the present work was to develop an in vitro toolbox to evaluate the oral administration of dosage forms to children of different age groups and under different administration conditions (fasted/fed). Based on current…
Phospholipids for Advanced OTC Formulations
Phospholipids are amphiphilic, endogenous molecules with excellent biocompatibility and tolerability. Therefore, they are an ideal choice for various “over-the-counter” (OTC) products, including formulations for sensitive tissue such as the…
Application of Response Surface Methodology to Improve the Tableting Properties of Poorly…
Designing a robust direct compression (DC) formulation for an active pharmaceutical ingredient (API) with poor flow and compaction properties at a high API load is challenging. This study tackled two challenges: the unfavorable flow…
The Impact of Polymer Mixture Composition on the Properties of Electrospun Membranes for Drug…
Orally dispersible films (ODFs) prepared by an electrospinning are a novel type of pharmaceutical formulation. This dosage form has the potential to be beneficial for small children and the elderly, who can have problems with administration…
Bioactive chemlali olive derivatives and compounds useful for pharmaceutical purposes: A review
Several articles in the literature deal with and analyze components extracted from the olive tree, but these researches are mainly focused on the quality of olive oil and more precisely its volatile components, often related to their…
Design, Development, Evaluation, and In Vivo Performance of Buccal Films Embedded with…
Abstract
The therapeutic effectiveness of paliperidone in the treatment of schizophrenia has been limited by its poor oral bioavailability; hence, an alternative route could be appropriate. This study investigates the feasibility of…
Scale-up in Twin-screw wet granulation: Impact of formulation properties
The focus of this study was to investigate the sensitivity of different drug formulations to differences in process parameters based on previously developed scale-up strategies. Three different formulations were used for scale-up…
Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori…
Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in…