Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Caffeine–Oxalic Cocrystal Dissociation in Formulations: Role of Excipients
16. October 2017 Caffeine–oxalic acid cocrystal, widely reported to be stable under high humidity, dissociated in the presence of numerous pharmaceutical excipients. In…
Thermal properties of compacted pharmaceutical excipients
16. October 2017 Thermal properties of powders are critical material attributes that control temperature rise during tableting and roll compaction. In this study, various…
Questions and answers on sodium used as an excipient in medicinal products for human use
16. October 2017
Questions and answers on sodium used as an excipient in medicinal products for human use - EMA Guideline
1. What is sodium and why is it used as an excipient?
2. Which medicinal products…
Improving the pulmonary delivery of biopharmaceuticals by PEGylation
16. October 2017
More and more therapeutic proteins are developed for an administration by inhalation to treat respiratory diseases. PEGylation is an interesting approach for sustaining the residence time of these…
Using low-content active ingredients as an indicator of overall blend and tablet uniformities
16. October 2017 Blending uniformity studies are becoming more important during product development within the dietary supplement industry . A multivitamin and…
The Complexity of Excipient Composition
15. October 2017 Since the United States Pharmacopeia (USP) and National Formulary (NF) General Notices combined, it could be interpreted that API requirements apply to…
Process endpoint determination of colour coated tablets
15. October 2017 Endpoints of coating processes for colored tablets were determined using in-line Raman spectroscopy. Coatings were performed with six commercially available…
PAT process analysers in monitoring of film coating processes
14. October 2017
Over the last two decades, regulatory agencies have demanded better understanding of pharmaceutical products and processes by implementing new technological approaches, such as processanalytical technology…
pH-sensitive and colon-targeting hydrogel microspheres for ulcerative colitis therapy
14. October 2017 Hydrocortisone sodium succinate (HSS) is an anti-inflammatory drug, but its application on ulcerative colitis (UC) treatment is limited by its associated…
Thermostability of the coating, antigen and immunostimulator in an adjuvanted oral capsule vaccine…
14. October 2017 Oral vaccines present an attractive alternative to injectable vaccines for enteric diseases due to ease of delivery and the induction of intestinal immunity at…
Excipients labelling – EMA information
13. October 2017
The European Medicines Agency (EMA) publishes information on excipients for inclusion in the labelling and package leaflet of human medicines.
EMA excipient definition:
"An excipient is a…
Controlled shear system and resonant acoustic mixing
13. October 2017 Purpose Lubrication is critical in pharmaceutical manufacturing of solid dosage forms. The purpose of this paper is to systematically compare and…
Lamotrigine extended release tablet based on a controlled-porosity osmotic pump system
13. October 2017 Osmotic pump delivery systems have made significant advances inthe past decades for controlled drug release over a long period of time. Usually, osmotic pump…
Unlocking Bioavailability
13. October 2017 The majority of New Chemical Entitities (NCEs) beingconsidered for therapeutic applications are BCS Class II, Class III, or Class IV, indicating that these…
Carrier free paracetamol nanosuspension prepared using different stabilizers
12. October 2017 Poor aqueous solubility leading to poor oral bioavailability is a bottle neck in the development of many new drug candidates; particularly the BCS class…
Process Control Design & Risk Analysis in Continuous Solid-Dosage Manufacturing
12. October 2017 Process Control Design & Risk Analysis in Continuous Solid-Dosage Manufacturing The paradigm shift in the pharmaceutical industry to continuous…
3D printed Anti-tuberculosis drug combination for controlled oral delivery
12. October 2017 The design and production of an oral dual-compartmental dosage unit (dcDU) was examined in vitro and in vivo with the purpose of physically isolating and…
9th Global Drug Delivery & Formulation Summit
12. October 2017 9th Global Drug Delivery & Formulation Summit 12 – 14 March 2018 | Berlin www.ddfevent.com
Biogrund Newsletter Autumn 2017
12. October 2017 Latest BIOGRUND @ CPhI worldwide, Frankfurt, 24-26 October 2017 Seminar Coating & Tabletting Workshop @ BIOGRUND On the 12 -…
Ranitidine floating tablets using different polymer combinations
12. October 2017 The current study was designed for preparation of gastro-retentive floating tablet of ranitidine HCl by using polymers ethyl cellulose (EC) and…
Modeling of Cellulosic Polymers for Drug Delivery in Solid Dispersions
12. October 2017 Solid dispersion formulation is a promising method to maintain in vivo drug solubility and to improve drug efficacy. However, the exact drug stabilization…
Optimization of Chitosan Microspheres Spray Drying
12. October 2017
Background: Generally, the preparation of spray-dried microspheres is strongly affected by the process parameters. Particle size and production yield are mainly in fluenced by the spraying solution…
A look into the world of cannabinoid formulation
12. October 2017 For ages, cultures all over the world have recognized the medicinal value of cannabinoids and they were widely used that way in the USA until…
Mouthfeel of ODT with Functionalized Calcium Carbonate
11. October 2017 Orally disintegrating tablets (ODT) are comfortable and safe drug delivery methods beneficial for all age groups of patients. ODTs are characterized by fast…
Sustained release venlafaxine hcl pellets
11. October 2017 The objective of this study was to formulate, optimize and evaluate sustained release pellets of venlafaxine hydrochloride. Venlafaxine hydrochloride…
Brand Protection for Pharmaceutical + Nutraceutical
11. October 2017 TruTag Technologies guides pharmaceutical and nutraceuticalcompanies in navigating the complexities of the supply chain by mitigating risks due to unauthorized…
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10. October 2017 Exceptional drug solubilization in diluted surfactant solutions Solubility screening in different surfactant solutions is an important part of pharmaceutical…
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10. October 2017 Captisol will be at booth #1913 at AAPS in San Diego - Get a sample! Captisol® is uniquely modified cyclodextrin, whose chemical structure was rationally…
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10. October 2017
Patient Centricity I: Patient Input to Improve Patient Outcomes
Looking at affordability and patient-recorded outcomes, the panel will address the future of immuno-X therapies, therapy experiences and…
Ophthalmic Biomaterials
09. October 2017 Either through collaboration or the pursuit of my own ideas, numerous ophthalmic biomaterials were created and tested. PNIPAAm based thermosensitive…
Optimization of Tenofovir release from mucoadhesive vaginal tablets
09. October 2017 The use of sustained-release mucoadhesive vaginal tablets of antiretroviral drugs as microbicidal formulations can be an effective strategy for reducing the…
Amorphous stabilization of poorly soluble drugs – Upsalite
09. October 2017 It is a well-known fact that the dissolution rate is higher for the amorphous form of a poorly soluble drug than from its various crystal forms. However,…
Enhancing the viability of Lactobacillus rhamnosus GG after spray drying and during storage
08. October 2017
Increasing knowledge about the human microbiome has led to a growing awareness of the potential of applying probiotics to improve our health. The pharmaceutical industry shows an emerging interest in…
Dissolution Behavior HPMC/Eudragit®/Magnesium Aluminometasilicate Oral Matrices
07. October 2017 Burst drug release is often considered a negative phenomenon resulting in unexpected toxicity or tissue irritation. Optimal release of a highly soluble active…