Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Nano-sized solid dispersions based on hydrophobic-hydrophilic conjugates
29. September 2017 The aim of this study was to investigate hydrophilic-hydrophobic conjugates as new carriers for nano-sized solid dispersions (SDs). The amphiphilic…
Recent advances in nanocarrier-loaded gels
29. September 2017 The combination of pharmaceutical technologies can be a wise choice for developing innovative therapeutic strategies. The association of nanocarriers and…
Microencapsulated lipid nanoparticles for pulmonary delivery of biopharmaceutical agents
29. September 2017 A key point in the administration of biopharmaceuticals is the recognition of appropriate, effective, safe and biocompatible nanocarriers allowing…
INSTACOAT 4G – an innovative tablet coating formulation @ CPhI
29. September 2017
INSTACOAT 4G - an innovative tablet coating formulation @ CPhI
An innovative tablet coating formulation capable of reducing coating process time, energy and cost while maximizing the potential of…
Updates to the Permissible Ingredients Determination for listed medicines
29. September 2017
Therapeutic Goods (Permissible Ingredients) Determination No. 4 of 2017
27 September 2017
An updated version of the Therapeutic Goods (Permissible Ingredients) Determination was registered…
Ibuprofen in infants younger than 6 months: efficacy & safety?
29. September 2017 Ibuprofen in infants younger than 6 months: efficacy & safety? Background Ibuprofen is a non-steroidal anti-inflammatory drug frequently administered…
Co-Amorphization of Acyclovir with Oxalic Acid as an Excipient
29. September 2017 The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an excipient. Designated as ACV-oxalic acid,…
Cellulose Nanofibers as Excipient for the Delivery of Poorly Soluble Drugs
28. September 2017 Poor aqueous solubility of drugs is becoming an increasingly pronounced challenge in the formulation and development of drug delivery systems. To overcome…
New comprehensive mathematical model for HPMC-MCC based matrices to design oral controlled release…
28. September 2017 Acomprehensive model with all effective phenomena in drug release such as diffusion, swelling and erosion was considered. In this work, a mathematical model…
Diblock Terpolymers Are Tunable and pH Responsive Vehicles To Increase Hydrophobic Drug Solubility…
28. September 2017
Synthetic polymers offer tunable platforms to create new oral drug delivery vehicles (excipients) to increase solubility, supersaturation maintenance, and bioavailability of poorly aqueous soluble…
Four Challenges for Pulmonary Drug Delivery
28. September 2017 Respiratory diseases such as asthma, chronic obstructive pulmonarydisease (COPD), and idiopathic pulmonary fibrosis are among the most serious and widespread…
Improving the wetting and dissolution of ibuprofen using solventless co-milling
28. September 2017 The wetting and dissolution of a BCS class II drug (Ibuprofen) is enhanced by solventless solid dispersion technique using co-milling. The co-milling is…
Lyophilisation and concentration of chitosan/siRNA polyplexes
28. September 2017 Chitosan (CS)/siRNA polyplexes have great therapeutic potential for treating multiple diseases by gene silencing. However, clinical application of this…
Pharmacological Properties of Faster-Acting Insulin Aspart
28. September 2017 Purpose of Review Faster aspart is a new formulation of insulin aspart (IAsp) produced by adding the excipients niacinamide and…
Excipients Stakeholder Forum
28. September 2017 Rockville, Maryland, USAWednesday, November 29, 2017, from 1:00 p.m. - 4:00 p.m. More information & Registration
When variability in excipient quality is and isn’t acceptable
27. September 2017
Regardless of whether it’s prescription or over-the-counter, the ingredients on a drug product label typically include one, maybe two, active pharmaceutical ingredients (APIs). The rest of the list is…
Melt Extrusion of High-Dose Co-Amorphous Drug-Drug Combinations
27. September 2017 Purpose Many future drug products will be based on innovative manufacturing solutions, which will increase the need for a thorough understanding of the…
Intravenous paracetamol in neonates: safety, ethanol-drug interactions and efficacy
27. September 2017 Introduction A chart-review of 200 neonates randomly selected from the Neonatal Intensive Care Unit (NICU) of the university hospital in Copenhagen…
Safe excipient exposure in neonates and small children
27. September 2017 Background Several medicines frequently used in neonates and infants contain potentially harmful excip-ients like ethanol, propylene glycol (PG),…
Excipient (Type IV) DMF – 2nd Quarter 2017
26. September 2017 Updated list of Excipient US Drug Master Files extracted from the FDA list. New files from 2nd quarter 2017 and full list of active excipient DMFs (Type…
Biodegradable Nanoparticles for Delivering Drugs
26. September 2017
ABSTRACT- Dialysis is the only mode of available palliative therapeutic modality to patient with end stage of renal disease. Diabetes is one of the foremost common causes of chronic renal…
Mixing by Controlled shear system and resonant acoustic: Effects on lubrication and flow properties
26. September 2017 Purpose Lubrication is critical in pharmaceutical manufacturing of solid dosage forms. The purpose of this paper is to systematically compare and…
A novel approach to investigate the wettability of pharmaceutical powder blends
26. September 2017 The ability of Broadband Acoustic Resonance Dissolution Spectroscopy (BARDS) to assess the wettability of powder blends is investigated. BARDS is a novel…
ICH Quality Guidelines: An Implementation Guide
26. September 2017 Examining the implications and practical implementation of multi-disciplinary International Conference on Harmonization (ICH) topics, this book gives an…
Speeding Up Formulation Development
26. September 2017 QbD principles and strategic thinking can reduce the time required to optimize formulation. Predictive model development In the…
Annual Swiss Symposium in Pharmaceutical Medicine
26. September 2017
Drug Development in Special Populations
29 November 2017, Metropol Zurich
Continuous manufacturing Oral Solid Dosage Forms & PAT
26. September 2017 Continuous manufacturing Oral Solid Dosage Forms & PAT The next GSIA-Educational Course will take place on the 9th November 2017 at the Novartis Campus…
Regulatory Notes on Impact of Excipients on Drug Products and the Maillard Reaction
26. September 2017 In general, it is an important criterion that excipients remain inert throughout the shelf life of the formulated pharmaceutical product. However,…
Adult sensory panel to study palatability of a pediatric drug
26. September 2017 Purpose The recommended first-line treatment for young children infected with HIV includes the liquid formulation of the co-formulated protease…
Photostability in Pharmaceutical Dosage Forms
25. September 2017 Abstract Photodegradation is one of the major pathways of the degradation of drugs. Some therapeutic agents and excipients are highly sensitive to…
Erythromycin encapsulation in nanoemulsion-based delivery systems
25. September 2017 Abstract Poorly water-soluble and unstable compounds are difficult to develop as drug products using conventional formulation techniques. The aim of…
Evaluation of Mesoporous Silica Nanoparticles for Oral Drug Delivery
25. September 2017 Abstract The oral pathway is considered as the most common method for drug administration, although many drugs, especially the highly pH-…
Polyester-Based Nanoparticles for the Encapsulation of Monoclonal Antibodies
25. September 2017
Abstract
Aliphatic polyesters have been widely explored for biomedical applications (e.g., drug delivery systems, biomedical devices, and tissue engineering). Recently, polyesters have been…
Exogenous Cannabinoid Efficacy
25. September 2017 Abstract Endocannabinoid pharmacology is now relatively well understood with a number of endocannabinoids and endogenous cannabinoid neurotransmitters…