A novel oral film of carbomer/Poly(vinyl alcohol)/hydroxypropyl cellulose triple polymer loaded with Periplaneta Americana extract for enhancing the oral ulcer treatment
The liquid formulation of Periplaneta Americana extract (PAE) demonstrates significant efficacy in the treatment of oral ulcers. However, its limited ability to adhere to the oral cavity leads to a diminished therapeutic effect. This study aims to address this limitation by developing a Periplaneta Americana extract oral film (PAEOF) designed to…
Bilayered buccal films as child-appropriate dosage form for systemic administration of propranolol
07. September 2017 Abstract Buccal mucosa has emerged as an attractive site for systemic administration of drug in paediatric patients. This route is simple and…
Robust and smart hydrogels based on natural polymers
06. September 2017 Abstract This review summarizes recent progress of the robust and smart hydrogels prepared from natural polymers including polysaccharides,…
Development and Optimization of Orally and Topically Applied Liquid Crystal Drug Formulations
06. September 2017 Abstract: Liquid crystal (LC)-forming lipids represent an important class of biocompatible amphiphiles and their…
Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film…
06. September 2017 Abstract External lubrication is a useful method which reduces the adhesion of powder to punches and…
Development and Evaluation of Topical Gabapentin Formulations
06. September 2017 Abstract: Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions whilst avoiding systemic side effects.…
Effect of the External Lubrication Method for a Rotary Tablet Press on the Adhesion of the Film…
05. September 2017 Abstract External lubrication is a useful method which reduces the adhesion of powder to punches and dies by spraying lubricants during the…
Supersaturating drug delivery systems: the potential of co-amorphous drug formulations
05. September 2017 Abstract Amorphous solid dispersions (ASDs) are probably the most common and important supersaturating drug delivery systems for the formulation of…
Downstream drug product processing of itraconazole nanosuspension
05. September 2017 Downstream drug product processing of itraconazole nanosuspension: Factors influencing tablet material properties and dissolution of compacted nanosuspension-la…
Excipient risk assessment: possible approaches to assessing the risk associated with excipient…
04. September 2017 Abstract Excipients are an integral part of practically all medicines. Historically, excipients have been regarded as pharmacologically and chemically…
Development of vildagliptin loaded Eudragit® microspheres by screening design
04. September 2017 Abstract The aim of this study was to develop and characterize sustained release vildagliptin (VLG) loaded Eudragit® RS-100 microspheres. The…
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Folic acid
04. September 2017 This work presents a review of literature and experimental data relevant to the possibility of waiving pharmacokinetic bioequivalence studies in human…
NSAIDS: Design and Development of Innovative Oral Delivery Systems
04. September 2017 Abstract Recently, different technologies have been used to transform active pharmaceutical ingredients (APIs) into new dosage forms.…
Expedited development of a high dose orally disintegrating metformin tablet
03. September 2017 Abstract Salt formation has been intensively used to improve drug properties, including solubility, stability and mechanical properties. A sweet…
Evaluation of tablet punch configuration on mitigating capping by a quality by design approach
02. September 2017 Abstract Capping is a common problem in the manufacture of some types of tablets and unless resolved, the tableting process cannot proceed. Hence, all…
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting…
02. September 2017 Abstract Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) comprise a category of versatile drug delivery systems that have…
Effect of surfactants and drug load on physico-mechanical and dissolution properties of…
01. September 2017 Abstract The aim of the present work was to prepare tadalafil (TDF) nanocrystals-loaded oral polymeric films (OFs) and investigate the effect of…
Spray drying ternary amorphous solid dispersions of ibuprofen
31. August 2017
Abstract
A design of experiment (DoE) approach was used to investigate the critical formulation and processing parameters in spray drying ternary amorphous solid dispersions (ASDs) of…
Hot melt extrudates formulated using design space: improved palatability and dissolution
31. August 2017
This work aimed to obtain an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according toa…
Lactose targeting mesoporous silica nanoparticles to deliver platinum(IV) prodrug for liver cancer…
30. August 2017 Abstract Chemotherapy is the most common therapeutic strategy for the treatment of unresectable hepatocellular carcinoma. However, the therapeutic…
Drug delivery by supramolecular design
30. August 2017 Abstract The rational design of drug delivery approaches leveraging supramolecular chemistry (i.e., “chemistry beyond the molecule”) has…
Impact of Eudragit EPO and Hydroxypropyl Methylcellulose on Drug Release Rate
30. August 2017 Abstract The purpose of this work was to evaluate the impact of polymer(s) on the dissolution rate, supersaturation and precipitation of indomethacin…
Assessment of swallowability and palatability of oral dosage forms in children
30. August 2017 Abstract The acceptability of pediatric pharmaceutical products to patients and their caregivers can have a profound impact on the resulting therapeutic…
Controlled-release solid dispersions of Eudragit® FS 100 and poorly soluble spironolactone
29. August 2017 Abstract Eudragit® FS (EudFS), a novel anionic metachrylate terpolymer with pH dependent solubility was processed using electrospinning (ES) for the first…
Formulation Development and Evaluation of Moxi oxacin.HCL Fast Dissolving Tablets
29. August 2017 ABSTRACT The main objective of present research investigation is to formulate the Moxi oxacin.HCl Fast Dissolving tablets. Moxi oxacin.HCl, a synthetic…
Developing suppository formulations for anti-HIV drug delivery
28. August 2017 Despite a long history of use for rectal and vaginal drug delivery, the current worldwide market for suppositories is limited primarily due to a lack of user…
Self-Emulsifying Formulation of Indomethacin with Improved Dissolution and Oral Absorption
28. August 2017 Objectives: The objective of the present study was to enhance the solubility, dissolution and hence anti-inflammatory activity of poorly soluble drug…
Effect of Kollidon VA®64 particle size and morphology as directly compressible excipient on tablet…
28. August 2017 Abstract The study evaluates use of Kollidon VA(®) 64 and a combination of Kollidon VA(®) 64 with Kollidon VA(®) 64 Fine as excipient in direct…
Patient-centered drug delivery and its potential applications for unmet medical needs
27. August 2017 Pharmaceutical dosage forms address diverse key components but satisfying unmet patient needs to enhance patient adherence is a major challenge. The desired…
Dry pre-coating of active pharmaceutical ingredient with submicron-sized hydroxypropylcellulose in…
26. August 2017 Abstract We aimed to investigate the feasibility of our previously proposed method for improving the properties of dry granules by pre-coating of active…
Pluronic polymers as a pharmaceutic excipient
24. August 2017 Abstract Chemotherapy is one of the most conventionally used therapeutic interventions for treating various diseases. Chances of acquiring multidrug…
HARKE Pharma announces ExciPact Certification of Chemfield Cellulose
24. August 2017 HARKE Pharma is proud to announce that our partner Chemfield Cellulose has gained the EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally…
Linking flowability and granulometry of lactose powders
24. August 2017 Abstract The flowing properties of 10 lactose powders commonly used in pharmaceutical industries have been analyzed with three recently improved…
Drug Product Development for Older Adults – Multiparticulate Formulations
23. August 2017 Abstract The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present…