Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Dry pre-coating of active pharmaceutical ingredient with submicron-sized hydroxypropylcellulose in…
26. August 2017 Abstract We aimed to investigate the feasibility of our previously proposed method for improving the properties of dry granules by pre-coating of active…
Pluronic polymers as a pharmaceutic excipient
24. August 2017 Abstract Chemotherapy is one of the most conventionally used therapeutic interventions for treating various diseases. Chances of acquiring multidrug…
HARKE Pharma announces ExciPact Certification of Chemfield Cellulose
24. August 2017 HARKE Pharma is proud to announce that our partner Chemfield Cellulose has gained the EXCiPACT Certificate from SGS, one of EXCIPACT’s internationally…
Linking flowability and granulometry of lactose powders
24. August 2017 Abstract The flowing properties of 10 lactose powders commonly used in pharmaceutical industries have been analyzed with three recently improved…
Drug Product Development for Older Adults – Multiparticulate Formulations
23. August 2017 Abstract The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present…
Effect of relative air humidity on the flowability of lactose powders
23. August 2017 Abstract Moisture is known to affect the flowing properties of powders. However, the quantification and the understanding of the observed effects are far…
A Multiparticulate Delivery System for Potential Colonic Targeting Using Bovine Serum Albumin as a…
22. August 2017 Purpose There are many important diseases whose treatment could be improved by delivering a therapeutic protein to the colon, for example, Clostridium…
Combined effect of moisture and electrostatic charges on powder flow
22. August 2017 Abstract It is well known in pharmaceutical applications involving powders and granular materials that the relative air humidity and the presence of…
Excipient risk assessment: Approaches based on excipient function
21. August 2017 Excipients / inactive ingredients are an integral part of practically all medicines. Although being a functional part of a formulation, excipients have been…
Microencapsulated Solid Lipid Nanoparticles as a Hybrid Platform for Pulmonary Antibiotic Delivery
21. August 2017
Solid lipid nanoparticles (SLN) containing rifabutin (RFB), with pulmonary administration purposes, were developed through a technique that avoids the use of organic solvents or sonication. To facilitate…
Improve pulmonary delivery of biopharmaceuticals by PEGylation
18. August 2017 The administration of therapeutic proteins by inhalation is getting more and more important to treat respiratory diseases. To enhance residence time of…
Formulation design of granules by wet granulation to avoid tableting failures
18. August 2017 Abstract We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We plotted “Compactability” on the…
Wheat in pharmaceutical Excipients – which excipients are based on it – is it a gluten…
18. August 2017
How many wheat (derived) excipients contain wheat / wheat starch as apotential source of Gluten? Based on available information most of the excipients such as Sodium StarchGlycolate, Pregelatinized…
A novel release retarding polymer for direct compression
17. August 2017
For the development of this excipient for direct compression no chemical modification was applied. The enhanced functionality enabling a nearly zero order release was achieved by techniques such as…
Call for Topics – Excipientfest 2018
17. August 2017 "Call For Topics". An IPEC excipient fest. The work on the educational program for 2018 has started. Do you have any excipient related topics you would…
The influence of apparent viscosity of AFFINISOL™ HPMC HME on hot melt extrusion processability and…
17. August 2017
AFFINISOL™ HPMC HME of varied viscosity was successfully processed with Itraconazole into homogenous amorphous solid dispersions. The use of two viscosity grades blended to a final target did not influence…
Atomic Layer Deposition − A Novel Method for the Ultrathin Coating of Minitablets
16. August 2017
A new coating method via Atomic Layer Deposition (ALD) to achieve an ultrathin coating / nanolayering of mini tablets.
The effects of ALD coating on the tablet characteristics and taste masking…
onCare – Evonik’s new customer portal
15. August 2017 e-Lab is now onCare We redesigned the platform for you - so that it's easier to find what you're looking for and to simplify your daily work.…
An investigation into the effects of excipient particle size, blending techniques and processing…
15. August 2017
Abstract
Powder blend homogeneity is a critical attribute in formulation development of low dose and potent active pharmaceutical ingredients (API) yet a complex process with multiple contrib- uting…
Nanoscale Kolliphor® HS 15 micelles to minimize rifampicin self-aggregation in aqueous media
15. August 2017
Abstract
Tuberculosis is a highly-deadly disease that affects both children and adults. Rifampicin, one of the “first-line” anti tuberculosis drugs, self-aggregates in aqueous solutions where…
A multi-technique characterization of the stability of surfactant containing solid dispersion based…
15. August 2017 Abstract This study investigates the stability of typically complex multi-component hydrophilic solid dispersions that could be used in a clinical…
Optimisation of HPMC ophthalmic inserts with sustained release properties as a carrier for…
15. August 2017 Abstract A methodology was developed and optimised for the preparation of a new drug delivery system (DDS) with sustained release properties to allow…
Modeling and comparison of release profiles: Effect of the dissolution method
15. August 2017 Abstract During the last decades, the study of the in vitro dissolution of pharmaceuticals has been strongly encouraged by the FDA in order to determine…
Oral delivery of a novel domain antibody (VorabodyTM) for the treatment of Crohn’s Disease
14. August 2017 Crohn’s disease (CD) is a serious and lifelong chronic inflammatory bowel disease (IBD) which can affect any part of the gastrointestinal tract (GIT) but…
Porous PLGA microparticles formed by “one-step” emulsification for pulmonary drug delivery: The…
14. August 2017 Abstract In the present study, by using a newly developed one-step emulsification technique, we tried to prepare porous PLGA particles having a proper…
Applications of ethylene vinyl acetate copolymers (EVA) in drug delivery systems
14. August 2017 Abstract The potential for use of polymers in controlled drug delivery systems has been long recognized. Since their appearance in the literature, a wide…
Microspheres of insulin-Eudragit complex: Formulation, characterization and in vivo studies
14. August 2017
Insulin, a hormonal drug for the management of diabetes mellitus has continued to attract attention of many researchers and pharmaceutical formulators for more than a decade. However, its low…
Technological solutions for encapsulation
14. August 2017 Abstract Encapsulation offers broad scope of applications. It can be used to deliver almost everything from advanced drugs to unique consumer sensory…
An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally…
14. August 2017 Abstract Taste detection systems using electronic sensors are needed in the field of pharmaceutical design. The aim of this study was to propose an…
Topical Vehicle Selection: Myths and Reality
13. August 2017 During the development of a dermal drug, much efforts tend to be placed on improving its delivery through skin. These efforts are driven by the known risk of…
Controlled Drug Release from a non-soluble & pH stable pellet system based on a novel type of…
11. August 2017
Controlled Drug Release from a non-soluble & pH stable pellet system based on a novel type of mesoporous silica
The goal of this study was to test the feasibility to load non-ordered, non-spherical…
Chemoinformatic Tools to Predict the Effects of Excipients in Generic Drugs
10. August 2017
Regulatory Science Challenge
Oral drug products such as tablets, capsules and solutions contain the active ingredient (medication) and various other ingredients that are considered to be…
Hydrogel-based capsules could expand and reside in the GI tract for days, slowly releasing…
10. August 2017 Around half of all medications for chronic diseases are not taken as prescribed, costing the U.S. health care system more than $100 billion in avoidable…