Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Engineering Synergistically Active and Bioavailable Cost-effective Medicines for Neglected Tropical…
10. August 2017
Abstract
Leishmaniasis is a neglected tropical disease responsible for the ninth largest disease burden in the world threatening 350 million people mostly in developing countries. The lack of…
Sticking and Picking in Pharmaceutical Tablet Compression: An IQ Consortium Review
10. August 2018 Sticking and picking during tablet manufacture has received increasing interest recently, as it causes tablet defects, downtime in manufacturing, and yield…
Everyone wins — the benefits of an excipient GMP certification programme
10. August 2018
Making a case for GMP certification of an excipient manufacturer should be a straightforward exercise since the benefits appear so clear cut and regulatory guidance in the EU underscores the value of certification.…
A novel technique for the visualization of tablet punch surfaces: characterization of surface…
09. August 2017 Abstract The surface quality of tablets is strongly related to the surface quality of the tablet punch. Therefore, regular control of the punch surfaces…
EMA Reflection paper on the pharmaceutical development of medicines for use in the older population
09. August 2017
According to Eurostat, the older population in the European Union is expected to grow from around 84 million in 2008 to approximately 141 million by 2050. The very elderly constitute the fastest growing …
Paediatric Medicines: Formulation Considerations
09. August 2017
The use of unlicensed and off-label medicines in children is widespread and has raised an increasing concern over the last years. The majority of medicines taken by children are extemporaneously…
Molecular characterization of excipients’ preferential interactions with therapeutic monoclonal…
09. August 2017
Objectives
This study reports global and local monoclonal antibody (mAb)–excipient interactions and the resulting thermodynamic and stabilization effects.
Methods
Molecular dynamics simulations are…
Furosemide ethanol-free oral solutions for paediatric use: formulation, HPLC method and stability…
09. August 2017 Background Oral liquid solutions of the diuretic active ingredient furosemide (FUR) marketed across Europe do not comply with recent requirements for…
UV imaging of multiple unit pellet system (MUPS) tablets: A case study of acetylsalicylic acid…
09. August 2017 Abstract The applicability of multispectral ultraviolet (UV) imaging in combination with multivariate image analysis was investigated to monitor API…
Soluplus as a Potential Enhancer of Cefixime – Solid dispersion
09. August 2017 The present study was done for improvement of solubility and thereby bioavailability of Cefixime for its e cient an microbial activity by using amphiphilic…
Melt Adsorption as a Manufacturing Method for Fine Particles of Wax Matrices without Any…
08. August 2017
Abstract
We have focused on melt adsorption as manufacture method of wax matrices to control particles size of granules more easily than melt granulation. The purpose of present study was to investigate…
Experimental Studies and Modeling of the Drying Kinetics of Multicomponent Polymer Films
08. August 2017 Abstract The process of drying thin polymer films is an important operation that influences the film structure and solid state, and the stability of the…
Calcium alginate microspheres containing metformin hydrochloride niosomes and chitosomes aimed for…
07. August 2017
Abstract
Metformin is an oral hypoglycemic agent used in the type 2 diabetes, whose poor bioavailability and short half-life make the development of effective extended-release formulations…
Pregelatinized hydroxypropyl pea starch as matrix forming material for lyophilized orodispersible…
07. August 2017
Abstract
Oral fast-disintegrating dosage forms, also known as ‘fast-disintegrating’ or ‘fast-dissolving’ dosage forms, are a relativelynovel dosage technology that involves the rapid…
Development of a video-microscopic tool to evaluate the precipitation kinetics of poorly-water…
07. August 2017 Many drug candidates today have a low aqueous solubility, and hence may show a low oral bioavailability, presenting a major formulation and drug delivery…
Development of discriminative and predictive dissolution tests for immediate release oral dosage…
07. August 2017 A suitable dissolution test as a surrogate for in vivo absorption is highly attractive in the early stage of formulation development. Ideally, changes in…
Formulation of Extended-Release Gliclazide Tablet Using a Mathematical Model for Estimation of…
07. August 2017 Abstract Formulation of gliclazide in the form of extended- release tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a…
Multi-kinetics and site-specific release of gabapentin and flurbiprofen from oral fixed-dose…
07. August 2017 Abstract In this work, a fixed dose combination of gabapentin and flurbiprofen formulated as multilayer tablets has been designed, developed and in vitro…
Designing Optimized Formulations
07. August 2017 Design of experiment plays a crucial role in the optimization process of formulation development. The…
IPEC Announces 2017 Award Season Winners
07. August 2017
The International Pharmaceutical Excipients Council (IPEC) Foundation announced the 2017 award season winners, who will be recognized for their contributions to the field of excipients during the American…
Coating compliance — looking at the important considerations when coating tablets
07. August 2017 Jason Teckoe, technical director, Colorcon EMEA Tablets remain the most common solid oral dosage form for many reasons, including ease of…
Tablets of multi-unit pellet system for controlled drug delivery
05. August 2017 Abstract The tablet of multi-unit pellet system (TMUPS), using coated pellets, for controlled release of drugs is an effective therapeutic alternative to…
Targeted delivery of probiotics to enhance gastrointestinal stability and intestinal colonisation
05. August 2017 Abstract The aim of this work was to assess the viability of some commercial probiotics after exposure to gastric acid and the possibility of modifying…
Lipid nanocarriers for tamoxifen citrate/coenzyme Q10 dual delivery
04. August 2017 Abstract Nanotechnology based combinatorial therapy has emerged as an effective strategy for cancer treatment due to its synergistic activity, suppression…
Chitosan Based Materials and its Applications – Book
04. August 2017
This volume presents 10 reviews contributed by eminent researchers around the world on chitosan based materials. The introductory chapters present information on general characteristics of chitosan and…
Drug Delivery Innovations to Address Global Health Challenges for Pediatric and Geriatric…
04. August 2017 Abstract Despite significant advances in pharmaceutical and biotechnological drug discovery, the global population is plagued with many challenging…
Determination of the Bitterness Threshold of Cetirizine Dihydrochloride Minitablets using E-tongue,…
04. August 2017
Presentation @ 9th Conference of the European Paediatric Formulation Initiative (EuPFi) "Formulating better Medicines for Children" in Warshaw by Stephanie Keser, Glatt Pharmaceutical Services.
Link to…
Trends on Analytical Characterization of Polysorbates and Their Degradation Products in…
04. August 2017 Abstract Among many other applications, polysorbates (PSs) are used as the most common surfactants in biopharmaceutical products in particular to protect…
Patient acceptability of 3D printed medicines
03. August 2017 Abstract Patient-centric medicine is a derivative term for personalised medicine, whereby the pharmaceutical product provides the best overall benefit by…
Manufacturing of oral solid dosage forms using 3D inkjet printing
03. August 2017 Abstract Ink-jet printing is a precise and versatile technique that accurately deposits small volumes of solutions (pico litres) in specific locations.…
Early pediatric formulation development with new chemical entities: Opportunities of e-tongue…
03. August 2017 Astract The palatability of a pediatric drug formulation is one of the key prerequisites for therapeutic success. Liquid formulations are often chosen for…
Alginate modified with maleimide-terminated PEG as drug carriers with enhanced mucoadhesion
03. August 2017 Abstract The goal of this study was to generate a new mucoadhesive carbohydrate-based delivery system composed of alginate (Alg) backbone covalently…
Palm Olein Emulsion: a Novel Vehicle for Topical Drug Delivery of Betamethasone 17-Valerate
02. August 2017 Abstract This study aims to investigate the use of palm olein as the oil phase for betamethasone 17-valerate (BV) emulsions. The physicochemical…
Oral product input to the GI tract: GIS an oral product performance technology
02. August 2017 Abstract The patient receives a pharmaceutical product, not a drug. The pharmaceutical products are formulated with a drug, an active ingredient to…