Highly soluble magnesium oxide for the food and supplement industry
What is magnesium oxide?
Magnesium oxide is a chemical compound with the formula MgO. Magnesium oxide is inorganic, consists of white crystals, and is normally insoluble in water. It has a high elemental magnesium content of approximately 58–60 % and can be used in food supplements where space is limited, such as tablets or capsules. It is also…
Stability of medicines after repackaging into multicompartment compliance aids: eight criteria for…
02. August 2017 Introduction Multicompartment compliance aids (MCA) are widely used by patients. They support the management of medication and reduce unintentional…
Microgels of silylated HPMC as a multimodal system for drug co-encapsulation
02. August 2017 Abstract Combined therapy is a global strategy developed to prevent drug resistance in cancer and infectious diseases. In this field, there is a need of…
Melt Extrusion for a High Melting Point Compound with Improved Solubility and Sustained Release
28. July 2017
Abstract
The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern…
Speed change experiments in a rotary tablet press
28. July 2017 Introduction As part of the development of continuous manufacturing in the pharmaceutical industry, appropriate solutions dealing with short-term…
Pediatric Formulation Development – some of the topics @ EuPFi in September 2017
28. July 2017 A ‘taster’ session on designing taste-masked oral paediatric formulation prototypes and how to plan their palatability assessment…
Design of Finasteride-Loaded Nanoparticles for Potential Treatment of Alopecia
27. July 2017 Abstract Background/Aims: Androgenetic alopecia is an extremely common dermatological disorder affecting both men and women. Oral finasteride (FNS), a…
White paper: Optimising excipient properties for ODT formulation
27. July 2017 Orally disintegrating tablets (ODTs), also known as orodispersible tablets, are unique dosage forms formulated to improve their in vivo disintegration and…
Innovative Drinking Straw Drug Delivery System Helping Patients
27. July 2017
Many children make a disgusted face when they are supposed to take drugs. This is understandable: Medicine often tastes bitter and sometimes, the swallowing of tablets is difficult or even impossible. Also the…
Saturated phosphatidylcholine as matrix former for oral extended release dosage forms
26. July 2017
Abstract
The aim of this study was to evaluate the suitability of saturated phosphatidylcholine (Phospholipon® 90H) as extended release excipient in matrix tablets for three model drugs with different aqueous…
Applications and biotechnological production of mannitol
26. July 2017 Abstract Mannitol is a polyol or an alditol that is naturally found in many plants and can be produced by several microorganisms. Based on its beneficial…
A 30-Year History of PLG Applications in Parenteral Controlled Drug Release
26. July 2017 Poly(lactide-glycolide) has been used for drug-delivery applications because of its beneficial physicochemical properties, long safety record, and reliable…
Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for…
26. July 2017 Lipid-polymer hybrid nanoparticles: Development & statistical optimization of norfloxacin for topical drug delivery system Abstract Poly lactic acid is a…
Development of a Novel Polymeric Nanocomposite Complex for Drugs with Low Bioavailability
25. July 2017 Abstract Semi-synthetic biopolymer complex (SSBC) nanoparticles were investigated as a potential oral drug delivery system to enhance the bioavailability of…
In Situ Salification in Polar Solvents: a Paradigm for Enabling Drug Delivery of Weakly Ionic Drugs…
25. July 2017 Abstract Solubility challenge for a poorly water-soluble drug gets further intensified when it is weakly ionic because the most common solubility…
Effect of directly compressible excipient and treated agar on drug release of clopidogrel oral…
25. July 2017 Aim: In the present investigation, oral dissolving/dispersible/disintegrating tablets (ODTs) of clopidogrel were designed with a view to enhance the…
Challenges in oral peptide delivery: lessons learnt from the clinic and future prospects
25. July 2017 Therapeutic peptides have become very successful drugs due to their specificity, potency and low toxicity, but they show challenges for their delivery, due to…
Improving tadalafil dissolution via surfactant-enriched tablets approach: Statistical optimization,…
24. July 2017 AbstractTadalafil suffers from poor aqueous solubility that could lead to fluctuating blood levels and unreproducible effect. Thus, this work aimed at improving…
Recent advances in oral delivery of macromolecular drugs and benefits of polymer conjugation
24. July 2017 Abstract Oral administration of drugs is a two-edged sword – on one hand it is a non-invasive and easy-to-handle administration of drugs, on the other hand…
Dual centrifugation – a new technique for nanomilling of poorly soluble drugs and formulation…
24. July 2017 Abstract The development of nanosuspensions of poorly soluble APIs takes a lot of time and high amount of active material is needed. In this publication the…
How to identify and manage ‘problem’ excipients in medicines for children
24. July 2017
Children may be exposed to potentially harmful excipients, essential components of drug formulations, through unlicensed and off-label use of adult medicines. Excipient exposure should be minimised, although a…
Science of Stability – 3rd Annual Conference 2017
24. July 2017
3rd - 5th October 2017
Crowne Plaza Hotel, Dublin, Ireland
More Information & Registration
In-depth experimental analysis of pharmaceutical twin-screw wet granulation in view of detailed…
23. July 2017 Abstract Twin-screw wet granulation is gaining increasing interest within the pharmaceutical industry for the continuous manufacturing of solid oral dosage…
Continuous Manufacturing of Pharmaceuticals – Book
23. July 2017 A comprehensive look at existing technologies and processes for continuous manufacturing of pharmaceuticals As rising costs outpace new drug development,…
Brain targeting efficiency of antimigrain drug loaded mucoadhesive intranasal nanoemulsion
22. July 2017 Abstract Zolmitriptan (ZT) is a well-tolerated drug in migraine treatment suffering from low bioavailability due to low amount of the drug that reaches the…
Challenges and Strategies to Facilitate Formulation Development of Pediatric Drug Products: Safety…
21. July 2017
Abstract
A public workshop entitled “Challenges and strategies to facilitate formulation development of pediatric drug products” focused on current status and gaps as well as recommendations for risk-based…
Comparative impact of different binder addition methods, binders and diluents on resulting granule…
21. July 2017 Abstract This study investigated comparative impact of different binder addition methods (pouring, dripping, spraying), binders and diluents on resulting…
Effect of polymer type on the surface energy of acetaminophen solid dispersions prepared by melt…
21. July 2017
Abstract
Many newly developed active pharmaceutical ingredients (APIs) have very low solubility in aqueous media. The preparation of solid dispersions (SDs) is one way of avoiding this problem.…
Review – An update on the use of oral phospholipid excipients
The knowledge and experiences obtained with oral phospholipid excipients is increasing continuously. Nevertheless the present number of oral products using these excipients as essential excipient is very limited. This is…
Limited Influence of Excipients in Extemporaneous Compounded Suspensions
19. July 2017 Objective: The objective of this study was to identify whether compounding oral suspensions with SyrSpend SF based on tablets or capsules is a suitable…
Excipient-mediated alteration in drug bioavailability in the rat model depends on the sex of the…
19. July 2017 Abstract The pharmaceutical excipient, polyethylene glycol 400 (PEG 400), unexpectedly alters the bioavailability of the BCS class III drug ranitidine in a…
Design, Preparation and Evaluation of HPMC-Based PAA or SA Freeze-Dried Scaffolds for Vaginal…
19. July 2017 Purpose Aim of this work was preparation of bioadhesive gel formulations based on Hydroxypropyl methylcellulose (HPMC), Poly(acrylic…
Increased drug load and polymer compatibility of bilayered orodispersible films
19. July 2017 Abstract The addition of enalapril maleate to a casting solution for orodispersible films (ODFs) containing hypromellose and carbomer 974P as film forming…
Going Natural: Using polymers from nature for gastroresistant applications
19. July 2017 Abstract Nutraceuticals provide an additional health or medicinal benefit besides their nutritional value and are therefore marketed for the prevention and…
Development of a novel ocular insert with slow release properties loaded with sodium fluorescein
19. July 2017
INTRODUCTION
Eye drops have been the most popular and best accepted dosage form for ocular delivery of drugs. However, conventional eye drops have well known disadvantages such as low ocular availability…