Phospholipids for Pediatric Dosage Forms
Safe and Endogenous Compounds for Pharmaceutical Applications
Phospholipids are ubiquitous, endogenous, and nutritional compounds. For pharmaceutical applications, phospholipids are safe and versatile excipients for any administration route. This is demonstrated by their long-standing use in several innovative pediatric drug products and their…
Drug solubility in lipid nanocarriers: Influence of lipid matrix and available interfacial area
17. July 2017 Abstract Amongst other strategies for the formulation of poorly water-soluble drugs, solubilization of these drugs in lipid-based formulations is a…
QbD Applications for Lipid-Based Pharmaceutical Products
14. July 2017 QbD applied through scientific approaches to the development and finalisation of LBF commercial processes can…
Selective Laser Sintering (SLS) 3D printing of medicines
13. July 2017
Abstract
Selective laser sintering (SLS) 3-dimensional printing is currently used for industrial manufacturing of plastic, metallic and ceramic objects. To date there are no reports on the use of SLS to…
Recent developments regarding a Novel Excipient Qualification process
13. July 2017
The International Consortium for Innovation and Quality in Pharmaceutical Development (IQ) and the International Pharmaceutical Excipients Council of the Americas (IPEC- Americas) are working…
Excipients & Formulation – Focus in July Edition of Tablets & Capsules
13. July 2017 Excipients & Formulation - Focus in July Edition of Tablets & Capsules A novel MCC for reducing segregation in direct-to-press…
Improving the solubility of nilotinib through novel spray-dried solid dispersions
12. July 2017
Abstract
The tyrosine kinase inhibitor nilotinib has a very low aqueous solubility and a low and variable oral bioavailability. A pharmaceutical formulation with an improved solubility may enhance the…
Customized release profiles using EUDRAGIT® polymers
12. July 2017 Functional EUDRAGIT® polymers offer a wide variety of formulation options, which allow formulation design tailored to specific therapeutic…
Resomer® Award 2017
11. July 2017
RESOMER® bioresorbable polymers are a synonym for innovation and vision, enabling both pharma and medical device companies to shape and design a better future for patients. RESOMER® is the foundation of an…
Orally Disintegrating Tablets – enhancing ease of use and patient compliance
11. July 2017
Orally disintegrating tablets (ODT), are an innovative solid oral dosage form that is becoming more and more important in the pharmaceutical market, both for prescription and over-the-counter…
Overcoming Excipient Challenges in Spray-Dried Dispersions
11. July 2017 Polymers and surfactants impact stability and long-term performance. Access to high-throughput synthesis and screening technologies has enabled…
Elimination of Ionization Suppressing Dosing Excipient from LC-MS Method for Bendamustine and M3 in…
11. July 2017 Poster Introduction Intravenously administered chemotherapy drug Bendamustine is readily hydrolyzed in vivo to mainly inactive metabolites, and partly to…
Die wichtigsten Verfahren zur Pelletherstellung
11. July 2017
Klaus Möller - Glatt GmbH
Pellets sind die Tausendsassas unter den festen Darreichungsformen. Angesiedelt irgendwo zwischen Pulver und Granulat, machen sie bittere Medizin verträglich und befriedigen in…
Film Forming Systems for Topical and Transdermal Drug Delivery
11. July 2017 Abstract Skin is considered as an important route of administration of drugs for both local and systemic effect. The effectiveness of topical therapy…
High-Concentration Protein Formulations: How High is High?
11. July 2017 Abstract High-concentration protein formulation (HCPF) is a term that is used to describe protein formulations, mostly monoclonal antibody (mAb) drugs, at…
Biopharmaceutical Evaluation and CMC Aspects of Oral Modified Release Formulations
11. July 2017 This article discusses the range of outcomes from biopharmaceutical studies of specific modified release (MR) product examples in preclinical models and…
An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems
11. July 2017 Abstract In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory…
Comparative in vitro and in vivo taste assessment of liquid praziquantel formulations
11. July 2017 Abstract The taste of pharmaceuticals strongly affects the compliance of patients. This study investigated the applicability of the electronic tongue and…
Concise Review: Considerations for the Formulation, Delivery and Administration Routes of…
10. July 2017 Abstract The drugs of biological origins have attracted the attention of many pharmaceutical companies where it is essential to protect the heterogeneous…
An Approach to Modeling Drug Release from Polymersome Nanoparticles Based on PNIPAM-g-PEO Graft…
10. July 2017 Abstract: The recently proposed by the authors numerical approach to modelling of drug release from polymersome nanoparticles based on PNIPAM-g-PEO graft…
Fluid Bed Technology for Coating of Application Devices (Sponges) with a Peptide Formulation
10. July 2017
Poster Introduction
Caries is the most common disease in the world. Great efforts have been undertaken for prevention and to identify a regenerative treatment solution for dental caries, especially for…
Addressing Solubility and Bioavailability Challenges by Adapting Excipients to Innovative…
10. July 2017
Presentation by Dr. Dieter Lubda, Director, R&D Operations of Actives and Formulation, Merck KGaA, Germany @ BIT's 7th Annual International Symposium of Drug Delivery Systems July 12-14, 2017…
Solid State Characterisation and Taste Masking Efficiency Evaluation of Polymer Based Extrudates of…
09. July 2017 Abstract Hot melt extrusion has gained considerable attention as a novel technique for taste masking of bitter APIs. The aim of this study was to…
Manufacturing classification system
09. June 2017
«The proposal coming from the Manufacturing classification system (MCS) working group represents a “guideline” for the formulator, that might be used as far as possible adapting it to the specific active…
Design, development and in vitro evaluation of sequentially optimized mesalamine tablets for optimum…
09. July 2017 Introduction Mesalamine has been used for treatment of diseases like ulcerative colitis and chron's disease which affect the colonic lumen and require local…
Overview on Zein Protein: A promising pharmaceutical excipient in drug delivery systems and tissue…
06. July 2017 Introduction: Natural pharmaceutical excipients have been applied extensively in the past decades owing to their safety and biocompatibility. Zein, a natural…
Tailoring Drug Release Properties by Gradual Changes in the Particle Engineering of Polysaccharide…
06. July 2017 Abstract Chitosan is a natural copolymer generally available in pharmaceutical and food powders associated with drugs, vitamins, and nutraceuticals. This…
The use of spray freeze drying for dissolution and oral bioavailability improvement of Azithromycin
06. July 2017 Abstract Azithromycin is a poorly water-soluble drug with a low bioavailability. The main purpose of this investigation was to increase the solubility and…
Design space and critical points in solid dosage forms
05. July 2017 Abstract The current regulatory environment based on the ICH guidelines encourages a systematic and science-based approach in the pharmaceutical…
Preparation and evaluation of oral multiparticulate formulations of acid-labile drugs
05. July 2017 Acid-labile drugs are easily degraded in acidic medium, which have been mainly formulated as enteric-coated dosage forms for oral administration. The objective…
Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs
05. July 2017 In this poster, Merck evaluate a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application… More than 80 % of current…
Drug Delivery to the Lungs Conference
04. July 2017 6th Dec - 8th Dec 2017 - Edinburgh More Information & Registration Call for Papers Deadline – 28th July 2017…
Effect of different production variables on the physical properties of pellets prepared by…
03. July 2017 Abstract Background: The spheronization process is a rapidly expanding technology which provides a uniform and predictable transport in the gastrointestinal…
DEM investigation of the role of friction in mechanical response of powder compact
03. July 2017 Abstract The discrete element method (DEM) based simulations were conducted to study the effects of particle-particle and particle-wall frictions on the…