Development, Pharmacokinetics and Antimalarial Evaluation of Dose Flexible 3D Printlets of Dapsone for Pediatric Patients
The focus of current studies was to fabricate dose flexible printlets of dapsone (DDS) for pediatric patients by selective laser sintering (SLS) 3D printing method, and evaluate its physicochemical, patient in-use stability, and pharmacokinetic attributes. Eight formulations were fabricated using Kollicoat® IR, Eudragit® L-100-55 and StarCap®as…
Design space and critical points in solid dosage forms
05. July 2017 Abstract The current regulatory environment based on the ICH guidelines encourages a systematic and science-based approach in the pharmaceutical…
Preparation and evaluation of oral multiparticulate formulations of acid-labile drugs
05. July 2017 Acid-labile drugs are easily degraded in acidic medium, which have been mainly formulated as enteric-coated dosage forms for oral administration. The objective…
Polyvinyl alcohol in hot melt extrusion to improve the solubility of drugs
05. July 2017 In this poster, Merck evaluate a pharmaceutical grade polyvinyl alcohol (PVA) as the matrix polymer for HME application… More than 80 % of current…
Drug Delivery to the Lungs Conference
04. July 2017 6th Dec - 8th Dec 2017 - Edinburgh More Information & Registration Call for Papers Deadline – 28th July 2017…
Effect of different production variables on the physical properties of pellets prepared by…
03. July 2017 Abstract Background: The spheronization process is a rapidly expanding technology which provides a uniform and predictable transport in the gastrointestinal…
DEM investigation of the role of friction in mechanical response of powder compact
03. July 2017 Abstract The discrete element method (DEM) based simulations were conducted to study the effects of particle-particle and particle-wall frictions on the…
Continuous Manufacturing: What Is Next?
03. July 2017
As an industry, we are uncovering ways to treat more complex targets, develop precision medicines, and advance transformative therapies. This evolving drug development landscape has resulted in therapid…
Overview on Zein Protein: A promising pharmaceutical excipient in drug delivery systems and tissue…
03. July 2017 Abstract Natural pharmaceutical excipients have been applied extensively in the past decades owing to their safety and biocompatibility. Zein, a natural…
Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil: formulation,…
03. July 2017 Two key steps that affect oral bioavailability of drugs are dissolution and gastrointestinal permeation. These two parameters are dictated by the intrinsic…
The future of pharmaceutical quality and the path to get there
03. July 2017 Abstract While six sigma quality has long been achieved in other industries, it is rarely seen in the pharmaceutical sector. However, consumers and patients…
Continuous or batch? A quality question
03. July 2017 Industry delegates say the US Food and Drug Administration (FDA) is showing increased support for continuous manufacturing, a stance C-SOPS told us is quality…
Electrospun hypromellose-based hydrophilic composites for rapid dissolution of poorly water-soluble…
03. July 2017 Abstract Hypromellose (HPMC)-based hydrophilic composites (HCs) used for rapid dissolution of ferulic acid (FA) were investigated. Electrospun and casting…
Amorphous Solid Dispersion of Furosemide as a Sublingual Bioadhesive Film
30. June 2017 Abstract: Administered by an oral route, Furosemide (FUR), a diuretic used in several edematous states and hypertension, presents bioavailability…
Photo stability of Risperidone in Tablets
30. June 2017 The purpose of this study is to evaluate the photostabilization mechanism of risperidone tablets. Risperidone is widely used for sensory integration…
Importance Of Excipient Selection In The Process Of Oral Liquid Formulation Development
30. June 2017
When developing an oral liquid dosage formulation, consideration is first given to the characteristics of the active drug. The major challenges in developing oral liquid dosage forms are (i) the stability of a…
11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
30. June 2017 19 March to 22 March 2018 | Granada, Spain Information & Registration Key Note Lecture Drug development for the world…
Polymorphic Transition of Lipid Particles obtained with the PGSS Process for Pharmaceutical…
29. June 2017 Abstract The bioavailability of a pharmaceutical depends on the crystal structure of a polymorphic active ingredient or excipient. By changing the process…
PAT INSIGHTS – Real-time prediction of polymer multiparticulate dissolution using process…
29. June 2017
Case Study :
Real-Time Prediction of Polymer-Coated Multiparticulate Dissolution using Process Analytical Technology
Process Analytical Technology, or "PAT" is the term given to analytical…
Macromolecular confinement of therapeutic protein in polymeric particles for controlled release:…
28. June 2017 ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of…
Effect of amphiphilic graft co-polymer-carrier on physical stability of bosentan nanocomposite:…
28. June 2017
Abstract
Bosentan is a dual endothelin receptor antagonist used in the treatment of pulmonary arterial hypertension (PAH). But the solubility and bioavailability of this drug are poor, which has restricted…
Ammonio methacrylate copolymer as a carrier for water-insoluble drug, preparation and…
28. June 2017 Abstract The use of ammonia methacrylate copolymer as a carrier for the preparation of oral controlled-release matrix tablets containing water-insoluble…
ICH M9: Biopharmaceutics Classification System Biowaivers
27. June 2017 Introduction The International Conference on Harmonization (ICH) M9: Biopharmaceutics Classification System-based Biowaivers,1,2 was adopted in mid-June…
Biosimilar and Interchangeable Biologics: What Is What?
27. June 2017
For decades, everybody has become familiar with many brand-name and generic chemically synthesized drugs that are small molecule drug products, such as amoxicillin, Lipitor, and Crestor. Biological products,…
A Quality by Design Approach for Coating Process Parameter Optimization
26. June 2017 Film coating is a thin polymer layer applied on to a solid dosage form. Quality by design approach was explored to optimize the tablet coating process using…
Mesoporous silica-based dosage forms improve bioavailability of poorly soluble drugs in pigs: case…
26. June 2017 Objectives Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid…
Retrospective Quality by Design (rQbD) applied to the optimization of orodispersible films
26. June 2017 Abstract The study demonstrates the application of QbD based on historical data for a product at a later development stage – retrospective QbD (rQbD). More…
Taste-masking assessment of orally disintegrating tablets and lyophilisates with cetirizine…
26. June 2017 Abstract Orally disintegrating tablets and oral lyophilisates are novel attractive dosage forms that disintegrate or dissolve in the buccal cavity within…
Nanostructured lipid carriers as oral delivery systems for poorly soluble drugs
26. June 2017 Abstract Poorly water soluble (PWS) drugs lack from good oral absorption, which limits their oral administration, the most common drug delivery route. The…
Oral Disintegrating Tablets:Background and Review on Recent Advancements
26. June 2017 Most of the drug products available in the market are for oral drug administration. Oral route is preferred due to ease of administration, versatility, patient…
Artificial Intelligence: The Future of Pharma
23. June 2017
In the past, machines were considered as tools that reduce human effort by performing tasks that humans are capable of, except thinking and learning. Machines, these days, come with cognitive skills as well,…
What does the future hold for pharmaceutical excipients?
22. June 2017 Many of the excipients we use today have been around for more than fifty years. In many cases, the specifications for those excipients have not…
Application of surfactants in solid dispersion technology for improving solubility of poorly water…
22. June 2017 Abstract Discovery of several poorly water soluble drugs in the past decade has led to the need of developing a novel dosage form which increases the…
Oral solid self-nanoemulsifying drug delivery systems of candesartan citexetil
21. June 2017 Abstract Candesartan cilexetil is an ester prodrug antagonist to angiotensin II receptor type 1 (AT1) used in management of many cardiovascular diseases.…
An investigation into the effects of excipient particle size, blending techniques and processing…
21. June 2017 Powder blend homogeneity is a critical attribute in formulation development of low dose and potent active pharmaceutical ingredients (API) yet a complex…