Melatonin hyalurosomes in collagen thermosensitive gel as a potential repurposing approach for rheumatoid arthritis management via the intra-articular route
Despite the fact that several rheumatoid arthritis treatments have been utilized, none of them achieved complete joint healing and has been accompanied by several side effects that compromise patient compliance. This study aims to provide an effective safe RA treatment with minimum side effects through the encapsulation of melatonin (MEL) in…
Scale-up in Twin-screw wet granulation: Impact of formulation properties
The focus of this study was to investigate the sensitivity of different drug formulations to differences in process parameters based on previously developed scale-up strategies. Three different formulations were used for scale-up…
Microparticles and nanoparticles-based approaches to improve oral treatment of Helicobacter pylori…
Helicobacter pylori is a gram-negative, spiral-shaped, flagellated bacterium that colonizes the stomach of half the world’s population. Helicobacter pylori infection causes pathologies of varying severity. Standard oral therapy fails in…
Drug Dissolution in Oral Drug Absorption: Workshop Report
Abstract
The in-person workshop “Drug Dissolution in Oral Drug Absorption” was held on May 23–24, 2023, in Baltimore, MD, USA. The workshop was organized into lectures and breakout sessions. Three common topics that were re-visited by…
Comparison of Mini-Tablets and Pellets as Multiparticulate Drug Delivery Systems for Controlled Drug…
Mini-tablets made into hard capsules or administered using special dosing units, as well as pellets in hard capsules or compressed into tablets, offer the advantages of multiparticulate drug delivery systems and are suitable for controlled…
Tailoring Dry Microparticles for Pulmonary Drug Delivery: Ultrasonic Spray Freeze-Drying with…
Abstract
Spray freeze-drying has emerged as a valid alternative to traditional spray drying to produce therapeutic dry microparticles. In particular, the spherical shape and high porosity of spray freeze-dried microparticles make them…
Handbook of Post-Processing in Additive Manufacturing – Part 2
Handbook of Post-Processing in Additive Manufacturing
See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh.
Description: Handbook of Post-Processing in Additive Manufacturing is a key…
The Effect of Compression Pressure on the First Layer Surface Roughness and Delamination of…
The objectives of this study were to evaluate the delamination of convex-shaped metformin HCl (MF) and evogliptin tartrate (EG) multi-layer tablets depending on the pre-compression and main compression pressures and simultaneously correlate…
Development, Characterization, and Ex Vivo Permeation Assessment of Diclofenac Diethylamine Deep…
Abstract
Purpose
The primary aim of this study is to introduce Therapeutic Deep Eutectic Systems (THEDES) as a novel, green, and biocompatible solvent system for the delivery of diclofenac diethylamine (DDEA), a non-steroidal…
Computational Amendment of Parenteral In Situ Forming Particulates’ Characteristics: Design of…
Lipid and/or polymer-based drug conjugates can potentially minimize side effects by increasing drug accumulation at target sites and thus augment patient compliance. Formulation factors can present a potent influence on the characteristics…
Pullulan hydrogels as drug release platforms in biomedicine
It is increasingly urgent to develop new therapeutic systems to combat the spreading and evolution of various pathologies globally. Nonspecific therapies and/or insufficient medication biodistribution might hinder the patient's recovery. In…
Extrusion-based technologies for 3D printing: a comparative study of the processability of…
Thermoplastic polyurethanes (TPU) offer excellent properties for a wide range of dosage forms. These polymers have been successfully utilized in personalized medicine production using fused deposition modeling (FDM) 3D printing (3DP).…
Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic…
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich amorphous nanoparticles generated in situ during ASD dissolution…
IFF and BASF collaborate on the Virtual Pharma Assistant Platform ZoomLab™
PRESS RELEASE
NEW YORK — Nov. 8, 2023 — IFF and BASF today announced a collaboration between the Pharma Solutions divisions of both companies, to onboard IFF’s leading product brands in pharmaceutical excipients into BASF’s Virtual Pharma…
Nanoemulsions as a Promising Carrier for Topical Delivery of Etodolac: Formulation Development and…
Abstract
This research primarily focuses on the development of innovative topical nanoemulsions for etodolac, aimed at surmounting its inherent limitations. The preparation of etodolac nanoemulsions is accomplished through a combination of…
Evaluation of Oromucosal Natural Gum-Based Emulgels as Novel Strategy for Photodynamic Therapy of…
Photodynamic therapy (PDT) recently has been shown as a promising option in the treatment of premalignant lesions of the soft oral tissues. Effective delivery of photosensitizer is challenging due to poor drug adherence to the oromucosal…
Preparation of Nanosized Pharmaceutical Formulations by Dual Centrifugation
Abstract
Dual centrifugation (DC) is an innovative in-vial homogenization and in-vial nanomilling technique that has been in use for the preparation of liposomes for more than one decade. Since then, DC has continuously been developed for…
Harnessing the multifunctionality of lipid-based drug delivery systems for the local treatment of…
Osteoarthritis (OA) is a widespread joint condition affecting millions globally, presenting a growing socioeconomic burden thus making the development of more effective therapeutic strategies crucial. This review emphasizes recent…
Handbook of Post-Processing in Additive Manufacturing – Part 1
Handbook of Post-Processing in Additive Manufacturing
See the new book, edited by Gurminder Singh, Ranvijay Kumar, Kamalpreet Sandhu, Eujin Pei, Sunpreet Singh.
Description: Handbook of Post-Processing in Additive Manufacturing is a key…
Topical Delivery of Terbinafine HCL Using Nanogels: A New Approach to Superficial Fungal Infection…
This study investigated pH-responsive Terbinafine HCL (TBH)-loaded nanogels as a new approach to treating superficial fungal infections. Acrylic acid (AA) is a synthetic monomer that was crosslinked with a natural polymer (gelatin) using a…
Design of experiments approach on the compaction properties of co-amorphous tablets
Co-amorphous systems are an evolving strategy to stabilize the amorphous form of a drug molecule with the aim of overcoming its poor water-solubility. With research focussing on the molecular level of co-amorphous systems, little is known…
Lignin-Based Covalent Adaptable Network Polymers ─ When Bio-Based Thermosets Meet Recyclable by…
Abstract
Covalent adaptable networks (CANs) play an important role in polymer chemistry, as they provide an innovative link between thermoplastics and thermosets. The breakthrough idea behind CANs is to at least partially replace…
Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer…
Abstract
Purpose
The objective of the current research work was to fabricate a fosfestrol (FST)-loaded self-nanoemulsifying drug delivery system (SNEDDS) to escalate the oral solubility and bioavailability and thereby the effectiveness…
Segregation of Formulated Powders in Direct Compression Process and Evaluations by Small Bench-Scale…
Powder segregation can cause severe issues in processes of pharmaceutical drugs for control of content uniformity if the powder is likely to be free or easy flowing. Assessing segregation intensity of formulated powders in a process is…
Clariant launched new range of excipients to improve stability and solubility of APIs at CPHI…
Press Release
Clariant Health Care expands the range of functional excipients to solve active pharmaceutical ingredient (API) delivery & bioavailability challenges
New effective carrier systems for drug delivery in different…
Poly(ɛ-caprolactone) and Eudragit E blends modulate the drug release profiles from FDM printlets
Abstract
Thermoplastic polymers have been used to produce filaments by hot melt extrusion (HME), which can be applied to obtain 3D printlets by fused deposition modelling (FDM). Poly(ε-caprolactone) (PCL) is a low melting point…
Facing some challenges during your coating process – Overwetting
Film coating agents for tablet medications
Tablets are among the most commonly used forms for oral administration. Film coating is the final step in tablet manufacturing. It is used to:
Protect cores from external aggression with a…
Evaluation of the effect of granule size of raw tableting materials on critical quality attributes…
Abstract
Objective
The effects of granule size of raw materials on tablet hardness (TH) and weight (TW) in the continuous tablet manufacturing process (CTMP) were investigated using near-infrared spectroscopy (NIRS).
Methods…
Preparation and evaluation of β-cyclodextrin-based nanosponges loaded with Budesonide for pulmonary…
Budesonide (BUD) is a glucocorticosteroid used to treat chronic obstructive pulmonary disease. Despite this, it is a hydrophobic compound with low bioavailability. To address these hurdles, non-toxic and biocompatible βcyclodextrin-based…
Adult Patients with Difficulty Swallowing Oral Dosage Forms: A Systematic Review of the Quantitative…
Abstract
The aim of this systematic review was to identify and critically appraise the available evidence regarding solid oral dosage forms (SODFs), e.g., tablets, and challenges regarding the oral administration of medicine to inpatients…
Topical formulation of high concentration of cationic-form lidocaine hydrochloride with anionic…
Benjamin Gavinet did an interesting presentation at the APGI Skin and Formulation conference in Nantes at the beginning of October. We did a small interview with him summarizing the most important topics and results of his presentation.…
Excipient Impact on Fenofibrate Equilibrium Solubility in Fasted and Fed Simulated Intestinal Fluids…
Solubility is a critical parameter controlling drug absorption after oral administration. For poorly soluble drugs, solubility is influenced by the complex composition of intestinal media and the influence of dosage form excipients, which…
Small patients, big challenges: navigating pediatric drug manipulations to prevent medication errors…
ABSTRACT
Introduction
Medication errors during drug manipulations in pediatric care pose significant challenges to patient safety and optimal medication management. Epidemiological studies have revealed a high prevalenceof medication…
In vivo pharmacodynamics of lactoferrin-coupled lipid nanocarriers for lung carcinoma: intravenous…
Lung carcinoma characterized by high mortality rate and poor prognosis; the efficacy of drug delivery should improve drug exposure at the targeted site. This study aims at evaluating lactoferrin role as targeting ligand besides the…
Processed excipients for targeted drug delivery in cancer management: Enhancing efficacy and…
Processed excipients (PEs) function in creating various dosage forms and need no introduction. For instance, recent studies have shown that PEs oleic acid, which is used with the breast cancer medicine Herceptin, functions both as a liquid…