Development, Pharmacokinetics and Antimalarial Evaluation of Dose Flexible 3D Printlets of Dapsone for Pediatric Patients
The focus of current studies was to fabricate dose flexible printlets of dapsone (DDS) for pediatric patients by selective laser sintering (SLS) 3D printing method, and evaluate its physicochemical, patient in-use stability, and pharmacokinetic attributes. Eight formulations were fabricated using Kollicoat® IR, Eudragit® L-100-55 and StarCap®as…
Lubrizol Invests $60 Million to Expand Particle Sciences, Vesta and Other Facilities in 2017
07. June 2017
CLEVELAND, June 6, 2017 /PRNewswire/ -- The Lubrizol Corporation announces its LifeSciences business continues to invest in its key capabilities through a variety of planned expansions. During this latest…
Molecular Dynamics Simulations of Amorphous Systems
07. June 2017 MD simulations reveal molecular interactions that may facilitate interpretation of experimental data Energy calculations enable…
Nanoporous Silica Particles for Enhanced Drug Performance: Applications Beyond Increasing Solubility
07. June 2017 Nanologica’s nanoporous silica technology is a versatile drug delivery platform that addresses formulation challenges for improved clinical benefit Key…
Mesoporous magnesium carbonate as a drug delivery vehicle for stabilising amorphous drugs and…
07. June 2017 In today’s drug discovery, the number of candidate drugs based on new molecular entities with poor aqueous solubility is increasing. Since poor aqueous…
Mesoporous Biomaterials: a Lexicon and Structured Bibliography of Reviews
07. June 2017 Accessing mesoporous and nanostructure biomaterial information can be particularly time consuming and problematic due to the interdisciplinary nature of the…
Efficacy and Safety of a Chewable Methylphenidate Extended-Release Tablet in Children with…
06. June 2017 Objective: This phase 3, laboratory classroom study assessed the efficacy and safety of methylphenidate hydrochloride extended-release chewable tablets (MPH…
Improving Patient Convenience: Challenges from the Formulation Front
06. June 2017 Patient centered integrated device implementation in early development Role of developability and pre-formulation development…
Application of ultrasound-assisted compression in pharmaceutical technology. Design and optimization…
05. June 2017 Abstract Ultrasound-assisted compression (USAC) is a technology combining a conventional compression process and US irradiation. These mechanical and…
In vitro and in vivo behavior of ground tadalafil hot-melt extrudates: How the carrier material can…
05. June 2017 Abstract Different types of ground hot-melt extrudates loaded with 10, 20 or 30 % of the poorly water-soluble drug tadalafil were prepared and characterized…
Trends in Excipient Demand
05. June 2017 Excipients play a key role in helping pharmaceutical manufacturers serve patients better through improved compliance and efficacy of treatment.…
New Excipients to Meet the Demands of a Challenging Industry
02. June 2017
Current trends in the pharma market, such as the discovery of increasingly lipophilic APIs, macromolecules, and biological actives have created a need for a more in-depth understanding of existing…
EXCIPIENT UPDATE – Solvent-Less Film Coatings: New Ethylcellulose Grade Enables Rapid Dry…
01. June 2017
INTRODUCTION
Ethylcellulose is a widely used film-forming polymer used to impart modified-release characteristics or mask poor-tasting ingredients. Ethylcellulose is broadly accepted due to its…
Overview of Multiparticulate Systems for Oral Drug Delivery
01. June 2017 Abstract Oral route remains the gold standard for drug delivery despite the new trends in the development of complex biotech therapeutic…
Roquette signs agreement to acquire Itacel and reinforce its global
01. June 2017 Press release - Roquette signs agreement…
IPEC – Excipients Insight May 2017
01. June 2017
Inside this issue
Introducing the new IPEC Europe Chair
Webinar - Good Distribution Practices for Pharmaceutical Excipients
New IPEC-PQG GMP Guide now available
Announcing the revised IPEC GDP…
SPRAY-DRIED DISPERSIONS – Particle Engineering of Spray Dried Dispersions: Considerations for…
01. June 2017
Amorphous solid dispersions (ASD) are a common formulation approach for orally delivered small molecule active pharmaceutical ingredients (APIs) whose oral bioavailability (BA) is limited by…
Investigation of polymorphic transitions of piracetam induced during wet granulation
31. May 2017 Abstract Piracetam was investigated as a model API which is known to exhibit a number of different polymorphic forms. It is freely soluble in water so the…
Can natural polymers assist in delivering insulin orally?
31. May 2017
Abstract
Diabetes mellitus is one of the most grave and lethal non communicable diseases. Insulin is normally used to medicate diabetes. Due to bioavailability issues, the most regular route of…
Natural lipids-based NLC containing lidocaine: From pre-formulation to in vivo studies
31. May 2017 Abstract In a nanotechnological approach we have investigated the use of natural lipids in the preparation of nanostructured lipid carriers (NLC). Three…
An explorative analysis of process and formulation variables affecting comilling in a vibrational…
31. May 2017
Abstract
Praziquantel, a BCS II class anthelmintic drug used for the treatment of schistosome infections, was coground in a vibrational mill with different polymers (linear and crosslinked…
3D Printed Orodispersible Films With Aripiprazole
31. May 2017 Abstract Three dimensional printing technology is gaining in importance because of its increasing availability and wide applications. One of the three…
Ashland Speciality Ingredients Belgium site receives EXCiPACT GMP certification
31. May 2017
EXCiPACT asbl is delighted to announce that the Ashland Speciality Ingredients site in Doel, Belgium has recently been awarded an EXCiPACT GMP Certificate from SGS, one of EXCIPACT’s internationally-recognised…
Quality by Design approach for studying the impact of formulation and process variables on product…
29. May 2017 Abstract The present investigation was carried out to understand the impact of formulation and process variables on the quality of oral disintegrating films…
Chitosan-clay nanocomposite microparticles for controlled drug delivery: Effects of the MAS content…
29. May 2017 Abstract Chitosan and clays can form nanocomposites via electrostatic interactions, offering an interesting potential as advanced drug delivery systems. Such…
Overview of solidification techniques for self-emulsifying drug delivery systems from industrial…
29. May 2017 Abstract Self-emulsifying drug delivery systems (SEDDS) are lipid formulations that improve solubility and oral bioavailability of the incorporated drug with…
5 Advantages of Calibrating Your Equipment At An Accredited Lab
In the manufacturing industry, equipment precision and instrument accuracy play a large role in the overall turnover of the organization. This is because the performance of the machinery and its accuracy in terms of output can…
Prediction of effects of punch shapes on tableting failure by using a multi-functional single-punch…
29. May 2017 Abstract We previously determined “Tableting properties” by using a multi-functional single-punch tablet press (GTP-1). We proposed plotting “Compactability”…
Revised IPEC GMP & GDP Guide for pharmaceutical Excipients available!
26. May 2017 Revised IPEC GMP & GDP Guide for pharmaceutical Excipients available! Announcing the publication and availability of the IPEC – PQG Good…
New Data Demonstrates Potential of Using In-Line Measured Coating Thickness to Predict Dissolution…
New Data Demonstrates Potential of Using In-Line Measured Coating Thickness to Predict Dissolution Profiles
Is there a…
Fasting during the ramadan: a challenge for patients with adrenal insufficiency
26. May 2017
During the Ramadan, Muslims fast every day, from dawn to sunset, for a whole month. The fast is a stressful period when individuals abstain from eating and drinking and are therefore at risk of dehydration,…
Comparative Physicochemical Characterization of Chitosan from Shells of Two Bivalved Mollusks from…
25. May 2017 Abstract The need to turn seafood wastes that hitherto constitute an environmental pollution into important pharmaceutical excipients is gaining ground…
Quality Attributes and In Vitro Bioequivalence of Different Brands of Amoxicillin Trihydrate Tablets
25. May 2017 Abstract: Bacterial resistance and antibiotic drug effectiveness can be related to administering generic products with a subtherapeutic dose or poor in…
The Need for Restructuring the Disordered Science of Amorphous Drug Formulations
25. May 2017 Abstract The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of…
Propafenone HCl fast dissolving tablets containing subliming agent prepared by direct compression…
25. May 2017 Abstract Propafenone HCl (PPH), an antiarrhythmic drug, has a bitter taste, short half-life, delayed drug dissolution and side effects. Thus, the purpose of…