Development, Pharmacokinetics and Antimalarial Evaluation of Dose Flexible 3D Printlets of Dapsone for Pediatric Patients
The focus of current studies was to fabricate dose flexible printlets of dapsone (DDS) for pediatric patients by selective laser sintering (SLS) 3D printing method, and evaluate its physicochemical, patient in-use stability, and pharmacokinetic attributes. Eight formulations were fabricated using Kollicoat® IR, Eudragit® L-100-55 and StarCap®as…
Challenges for the pharmaceutical technical development of protein coformulations
11. May 2017 Objectives This review discusses challenges to stability, analytics and manufacturing of protein coformulations. Furthermore, general considerations to be…
Biotech Outsourcing Strategies cmc 2017
11. May 2017 Basel - June 27-28, 2017 BOS cmc 2017 will cover development stage CMC outsourcing for both small molecules and biologics More Information…
QbD in paediatric formulations
10. May 2017 Obtaining formulations for paediatric diseases is one of the major challenges to face in the coming years. EMA, in the Guideline on pharmaceutical development…
Investigation of nanocarriers and excipients for preparation of nanoembedded microparticles
10. May 2017
Abstract
Colloidal drug delivery systems often face physical and chemical instability as well as challenges with directed delivery. In order to overcome these challenges the colloidal formulations can be…
Solution through compounding: Flavouring for children: Part 2
09. May 2017
Abstract: This article is the second part of a series on flavouring for children's formulations. Omeprazole has been chosen as an example of an active pharmaceutical ingredient (API) that is not…
Incorporation of lipolysis in monolayer permeability studies of lipid-based oral drug delivery…
08. May 2017 Abstract Lipid-based drug delivery systems, a well-tolerated class of formulations, have been evaluated extensively to enhance the bioavailability of poorly…
Evaluation of Maltose-Induced Chemical Degradation at the Interface of Bilayer Tablets
08. May 2017 Fixed dose combination tablets consisting of mirabegron (MB) and solifenacin succinate (SS) were developed and formulated into bilayer tablets in the current…
Development of a Rapidly Dissolvable Oral Pediatric Formulation for Mefloquine Using Liposomes
08. May 2017 Mefloquine (Mef), a poorly soluble and highly bitter drug, has been used for malaria prophylaxis and treatment. The dosage form for Mef is mostly available as…
Predicting Multiparticulate Dissolution in Real Time for Modified- and Extended- Release…
08. May 2017 Process analytical technology, based on monitoring particle size distribution and tracking coating thickness measurements in real time, can be used to predict…
EFFECT OF DIFFERENT TEMPERATURE AND RELATIVE HUMIDITY ON PACKED AND UNPACKED PHARMACEUTICAL…
05. May 2017
ABSTRACT
Microcrystalline cellulose (MCC) is a very popular excipient in pharmaceutical market. Consumption of MCC is increasing day-by-day. Influence of temperature and relative humidity (RH) on…
Methotrexate-loaded porous polymeric adsorbents as oral sustained release formulations
03. May 2017 Abstract Methotrexate as a model drug with poor aqueous solubility was adsorbed into porous polymeric adsorbents, which was used as oral sustained release…
Development and Evaluation of Orodispersible Tablet of Microwave Generated Co-Processed Material of…
03. May 2017 Abstract: Carbamazepine is an anticonvulsant and moodstabilizing drug used in the treatment of epilepsy and bipolar disorder. Certain limitations associated…
Nanoporous mannitol carrier prepared by non-organic solvent spray drying technique to enhance the…
03. May 2017 Abstract An optimum carrier rugosity is essential to achieve a satisfying drug deposition efficiency for the carrier based dry powder inhalation (DPI).…
Application of 3D Printing Technology in the Development of Novel Drug Delivery Systems
02. May 2017 Abstract Three-dimensional printing (3DP) is a unique prototyping technology that has advanced over the past 35 years and has the great potential to…
Influence of binder properties on dry granules and tablets
02. May 2017 Abstract Dry granules manufactured by roll compaction/dry granulation (RCDG) lead often to lower tensile strengths of tablets in comparison to direct…
Bioequivalence study of a new sildenafil 100 mg orodispersible film vs a conventional tablet
02. May 2017 Abstract: A new orodispersible lm formulation of the phosphodiesterase type 5 inhibitor, sildenafil, has been developed to examine the advantages of an…
Microcrystalline Cellulose: The Inexhaustible Treasure for Pharmaceutical Industry
02. May 2017 Abstract Microcrystalline cellulose (MCC) is pure partially depolymerized cellulose synthesized from α-cellulose precursor. The MCC can be synthesized by…
Enteric Coating of Micron-size Drug Particles through a Wurster Fluid-Bed Process
02. May 2017 Abstract Enteric coated active pharmaceutical ingredient (API) particles can provide advantages in clinical and pre-clinical formulation development…
Giornata di studio Quality by Design (QbD), 5a edizione. 5 maggio 2017
02. May 2017 Program QbD May 5, 2017 Brochure Giornata QbD…
Continuous Manufacturing – Live Show of Direct Compression by MODCOS @Interpack
02. May 2017 Experience one of the MODCOS applications for continuous manufacturing: Presentations of MODCOS Direct Compression @ Interpack:…
Drug Product Development for Older Adults – Multiparticulate Formulations
02. May 2017 Abstract The multiparticulate drug product concept covering micropellets, pellets and mini-tablets is presented as a highly feasible approach…
Freeze-dried cylinders carrying chitosan nanoparticles for vaginal peptide delivery
01. May 2017 Abstract Recently nanoparticle-based vaginal drug delivery formulations have been acquiring great attention for the administration of peptide based-vaccines…
Development of oral lyophilisates containing meloxicam nanocrystals using QbD approach
29. April 2017 Abstract The aim of this study was to develop oral lyophilisates with improved meloxicam (MEL) dissolution, optimizing each step of the preparation by…
Design of Clinical Formulations in Early Development
29. April 2017 Abstract Thoughtfully designed early clinical formulations not only meet the needs of the study at hand and inform the development of the commercial…
Rapidly-Disintegrating Laminar Extrudates: Preliminary Experiments upon an Age Appropriate Pediatric…
28. April 2017 Abstract The aim of the present investigation is to produce rapidly disintegrating laminar extrudates for delivering ibuprofen in the mouth of paediatric…
Optimization of film-coating formulation containing a novel low molecular weight hypromellose to…
28. April 2017 Abstract In recent years, a novel low molecular weight hypromellose (hypromellose 2906, VLV hypromellose) was developed to improve tablet-coating process…
Preformulation studies of ceftriaxone for pediatric non-parenteral administration as an alternative…
28. April 2017 Abstract Ceftriaxone, a third generation cephalosporin, has a wide antibacterial spectrum that has good CNS penetration, which makes it potentially…
The design and scale-up of spray dried particle delivery systems
28. April 2017 Areas covered: The review firstly presents a systematic analysis of the trends in development of particle delivery systems using spray drying. This is…
EXCI-CEST: Exploiting pharmaceutical excipients as MRI-CEST contrast agents for tumor imaging
28. April 2017 Abstract Chemical Exchange Saturation Transfer (CEST) approach is a novel tool within magnetic resonance imaging (MRI) that allows visualization of…
10th Life Science Forum Basel
28. April 2017
Wednesday the 14th of June 2017 from midday onwards at the Pathologie Building of the Unispital Basel
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EMA and FDA agree how drug firms should include Q8, Q9 and Q10 QbD concepts in applications
28. April 2017 The EMA and US FDA say they agree on how pharmaceutical firms should include quality-by-design (QbD) elements in drug approval and manufacturing change…
Application of the melt granulation technique in development of self-emulsifying tablets with…
26. April 2017 Abstract The aim was to develop immediate-release carbamazepine tablets consisting of self-emulsified drug delivery system (SEDDS) by using the melt…
Improving blend Content uniformity via dry particle coating of micronized drug powders
26. April 2017 Abstract Content uniformity of low dose blends with fine active pharmaceutical ingredients (API) is adversely impacted due to API agglomeration caused by…
Preparation of a colon-specific sustained-release capsule with curcumin-loaded SMEDDS alginate beads
26. April 2017 A colon-specific capsule with alginate beads containing a self-microemulsifying drug delivery system (SMEDDS) was developed and evaluated. The SMEDDS…