Development, Pharmacokinetics and Antimalarial Evaluation of Dose Flexible 3D Printlets of Dapsone for Pediatric Patients
The focus of current studies was to fabricate dose flexible printlets of dapsone (DDS) for pediatric patients by selective laser sintering (SLS) 3D printing method, and evaluate its physicochemical, patient in-use stability, and pharmacokinetic attributes. Eight formulations were fabricated using Kollicoat® IR, Eudragit® L-100-55 and StarCap®as…
World leading technology in laboratory scale containment pharma solutions – Glatt @ Corden…
17. April 2018 Corden Pharma in Plankstadt Germany trusts in Glatt Technology. In technological partnership with Weiss Pharmatechnik,…
Respiratory Drug Delivery Europe 2017 in Antibes
16. April 2017 RDD Europe 2017 will be held in Nice (Antibes) France, April 25-28, 2017 More Information & Registration
Bilateral Effects of Excipients on Protein Stability: Preferential Interaction Type of Excipient and…
16. April 2017
Purpose
Understanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The…
Have existing pharmaceutical excipients failed to enable oral/nasal protein delivery?
16. April 2017
Have existing pharmaceutical excipients failed to enable oral/nasal protein delivery?
ABSTRACT
It seems evident that the ill-defined weltanschauung of the past decade of enabling oral, un-truncated…
Formulation Development and Optimization of Oral Thin Films of Zolpidem Tartarate
13. April 2017
Abstract
The aim of the present study was to formulate and evaluate oral thin films of zolpidem tartarate.
Zolpidem tartarateis used to treat insomnia. It affects chemicals in your brain that may…
In-line moisture monitoring in fluidized bed granulation using a novel multi-resonance microwave…
13. April 2017 Abstract Microwave resonance technology (MRT) is known as a process analytical technology (PAT) tool for moisture measurements in…
Enhancement of albendazole dissolution properties using solid dispersions with Gelucire 50/13 and…
13. April 2017 Abstract The role of two carriers —Gelucire 50/13 and PEG 15000— was evaluated to improve the characteristics of the dissolution of albendazole, an…
Delivery of protein or peptide into the skin using cubosomes and microneedles
13. April 2017 Transdermal transport of high-molecular-weight and hydrophilic substances is complicated by the protective skin layer, the…
Parenteral control – challenges of formulating novel excipients
13. April 2017
While continuing to occupy a smaller market share of drug delivery than oral solid dosage, parenteral formulations are today a major focal point – not least because of rapidly growing interest in…
Cellulose-polysaccharide film-coating of cyclodextrin based pellets for controlled drug release
12. April 2017 Abstract An oral controlled release system based on blends of ethylcellulose and pectin as film-coating material for pellets was developed.…
Solidification of cinnarizine self-nanoemulsifying drug delivery systems by fluid bed coating:…
12. April 2017 Abstract: Self-nanoemulsifying drug delivery systems (SNEDDS) offer an efficient choice to improve the poor dissolution and erratic…
Two release rates from monolithic carboxymethyl starch tablets: formulation, characterization, and…
12. April 2017 Mostof non-steroidal anti-inflammatory drugs (NSAIDs) including ibuprofen at more than 1200 mg/day may generate gastrointestinal and cardiovascular side…
Chitin’s functionality as a novel disintegrant: benchmarking against commonly used disintegrants in…
12. April 2017 Abstract Disintegrants are used as excipients to ensure rapid disintegration of pharmaceutical tablets and further ensure proper dissolution of…
Formulation, stability testing, and analytical characterization of melatonin-based preparation for…
12. April 2017 Abstract A new institutional clinical trial assessed the improvement of sleep disorders in 40 children with autism treated by immediate release…
Preparation and investigation of controlled-release glipizide novel oral device with…
11. April 2017
Abstract
The purpose of this study was to explore the feasibility of combining fused deposition modeling (FDM) 3D printing technology with hot melt extrusion (HME) to fabricate a novel…
Solid-state transformations of ribavirin as a result of high-shear mechanical processing
11. April 2017 Abstract Ribavirin (C8H12N4O5; anti-viral agent) was crystallized as two unique, phase-pure polymorphs (R-I and R-II). Calorimetrically determined isobaric…
Development of polyethylene glycol and hard fat-based mucoadhesive tablets containing various types…
11. April 2017 Summary Topical drug application has the advantage of avoiding systemic side effects. We attempted to develop a long-acting matrix-type tablet containing…
Co-grinding Effect on Crystalline Zaltoprofen with β-cyclodextrin/Cucurbit[7]uril in Tablet…
11. April 2017 Abstract This work aimed to investigate the co-grinding effects of β-cyclodextrin (β-CD) and cucurbituril (CB) on crystalline zaltoprofen (ZPF) in tablet…
Roll Compaction Scale-Up: Impact of Material, Effect of Scale and Modelling of The Process Transfer
10. April 2017 This thesis is focused on investigating the scale-up of the roll compaction process by firstly considering the effect of plastic/brittle mixtures and process…
Esomeprazole magnesium enteric-coated pellet-based tablets with high acid tolerance and good…
10. April 2017 Abstract The aim of this study was to develop esomeprazole magnesium (EMZ-Mg) enteric-coated pellets and pellet-based tablets, as well as to investigate…
Dropwise Additive Manufacturing of Pharmaceutical Products for Amorphous and Self Emulsifying Drug…
10. April 2017 Abstract The improvements in healthcare systems and the advent of the precision medicine initiative have created the need to develop more innovative…
Excipient Presentations @Making Pharmaceuticals 2018
10. April 2018
Making Pharmaceuticals is covering the hot topics in the pharmaceutical industry from continuous manufacturing, supply chain, serialization, data integrity, regulatory, Brexit and many more in a 2…
New continuous agglomeration and next-generation control systems – Modular and compact…
10. April 2018
"Glatt goes Compact and Modular" - Glatt Ingenieurtechnik has added compact continuous agglomeration equipment and new control systems to its "Modular Plant Engineering" Portfolio.
At ACHEMA, the…
Tablet Coating – 20th Anniversary TTC Workshop
10. April 2018
On the one hand, increasing international competition is forcing companies to optimize their manufacturing and R&D processes. These trends increase quality and efficiency demands especially for the…
Co-Processed Excipients Help Formulate Better OSDs
08. April 2017
Co-processed excipients are expected to play a key role in the production of new chemical entities (NCEs), according to BCC Research. As developing new excipients can be time-consuming and…
European study of Neonatal exposure to Excipients (ESNEE)/Priomedchild Call/ERA-Net
08. April 2017
Technical Summary
Excipents are chemicals added to medicines to improve their quality. Sporadic reports indicate that some may be toxic for neonates and lead to significant morbidity or death. However,…
Developing a new high throughput screen method to improve excipient selection for solubilisation
08. April 2017 During the early stages of drug development, a compound is often solubilised to create a liquid formulation that can be used to evaluate the pharmacokinetics,…
Docusate Sodium – A Pharmaceutical Grade Excipient
08. April 2017 Docusate Sodium - A Pharmaceutical Grade Excipient Docusate sodium is a pharmaceutical grade surfactant, making it an efficient…
FORMULATION AND EVALUATION OF MICROSPHERE BASED ORO DISPERSIBLE TABLETS OF SUMATRIPTAN SUCCINATE
07. April 2017 ABSTRACT Sumatriptan succinate (SS) is a drug used in the treatment of migraine headaches, but suffers from low patient compliance due to its…
Preformulation investigation and challenges; salt formation, salt disproportionation and hepatic…
07. April 2017 Abstract A compound, which is a selective peroxisome proliferator activated receptor (PPAR) agonist, was investigated. The aim of the presented studies was…
Population Exposure to Phthalate-Containing Drugs
07. April 2017 Abstract Phthalates are known endocrine disruptors. Not commonly recognised, phthalates are used as excipients in a number of drug formulations. We aimed…
The effect of binder concentration and dry mixing time on granules, tablet characteristics and…
07. April 2017 Abstract High shear mixers are classically used for wet granulation because they provide granules with a high density and a high strength in a short…
DEVELOPMENT OF MICROPARTICLES FOR SUSTAINED RELEASE OF PROTEINS BASED ON LIPID AND SILICA MATERIALS
07. April 2017
Objectives of the thesis
Many protein drugs exhibit short half-lives in vivo and multiple dosing schemes and frequent injections are necessary to achieve therapeutic drug levels, which results in poor…