Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Polysaccharides as Excipients for Ocular Topical Formulations
30. March 2017 The topical treatment of extraocular or intraocular diseases, especially by eye drops, is the best accepted by patients. Treatment with eye drops, however,…
Clofazimine encapsulation in nanoporous silica particles for the oral treatment of…
30. March 2017 Aim: First extensive reformulation of clofazimine (CLZ) in nanoporous silica particles (NSPs) for tackling antibiotic-resistant tuberculosis (TB) infections.…
Synthesis of Biopolymer Materials Tailored for Biological Applications – Thesis
30. March 2017 Abstract Biopolymers are able to address a wide variety of medical concerns from chronic wounds to stem cell cultivation to antibacterial and antifouling…
An overview of carboxymethyl derivatives of chitosan: Their use as biomaterials and drug delivery…
30. March 2017 Abstract Chitin is one of the most abundant natural polymers in the world and is used for the production of chitosan by deacetylation. Chitosan is nontoxic…
Remineralization of natural early caries lesions in vitro by P11-4 monitored with photothermal…
30. March 2017
Abstract
Aim
The efficacy of self-assembling peptide P11-4 to regenerate enamel in natural early caries lesions was evaluated over 50 days by photothermal radiometry and luminescence using The Canary…
Elemental Impurities in Pharmaceutical Excipients
29. March 2017 ABSTRACT: Control of elemental impurities in pharmaceutical materials is currently undergoing a transition from control based on concentrations in components…
Enhanced gastric stability of esomeprazole by molecular interaction and modulation of…
29. March 2017 Abstract Due to the instability of esomeprazole magnesium dihydrate (EPM), a proton pump inhibitor, in gastric fluid, enteric-coated dosage form is…
Solid dispersions of drugs in hyaluronan matrix: The role of the biopolymer in modulating drug…
29. March 2017 Abstract It was demonstrated in this study that the treatment of physical mixtures of hyaluronic acid (HA) and oncology drugs raloxifene, letrozole, and…
Comparison of the protective effect of self-emulsifying peptide drug delivery systems towards…
29. March 2017 Aim The aim of this study was to evaluate the protective effect of self-emulsifying drug delivery systems (SEDDS) for therapeutic peptides towards…
Process analytical techniques for hot-melt extrusion and their application to amorphous solid…
29. March 2017 Abstract Newly developed active pharmaceutical ingredients (APIs) are often poorly soluble in water. As a result the bioavailability of the API in the…
Core/shell Eudragit/poly(ethylene oxide) fibers for site-specific release
29. March 2017 Abstract Electrospinning was used to prepare core/shell fibers containing the active pharmaceutical ingredients indomethacin (IMC) or mebeverine…
Dry powder inhaler performance of spray dried mannitol with tailored surface morphologies as carrier…
28. March 2017 Abstract Nowadays, dry powder inhalation as applied in the therapy of pulmonary diseases is known as a very effective route of drug delivery to the lungs.…
Pharmaceutical Solvates, Hydrates and Amorphous Forms
28. March 2017 Abstract Active pharmaceutical ingredients (APIs) may exist in various solid forms, which can lead to differences in the intermolecular interactions,…
Impact of degree of substitution of acetylated Ofada rice starch polymer on the release properties…
27. March 2016 Nimesulide microspheres were prepared by the quasi-emulsion solvent diffusion method, using acetylated starches of the indigenous Ofada rice (Oryza…
Recent advances in the design of polymeric microneedles for transdermal drug delivery and biosensing
27. March 2017 Microneedles is an efficient and minimally-invasive approach of transdermal drug delivery and extraction of skin interstitial fluid. Compared to solid…
Correlation between calculated molecular descriptors of excipient amino acids and experimentally…
26. March 2017 Abstract A quantitative structure-property relationship (QSPR) between protein stability and the physicochemical properties of excipients was investigated…
Modeling and analysis of dissolution of paracetamol/Eudragit® formulations
26. March 2017 Abstract In this work, amorphous paracetamol/Eudragit® formulations for four Eudragit® (polymeric excipients) were prepared by spray drying technique. The…
An innovative method for the preparation of high API-loaded hollow spherical granules for use in…
26. March 2017 Abstract The aim of this study was to prepare controlled-release (CR) granules with suitable particle strength, flowability, particle size distribution…
Formulation and Evaluation of Immediate Release Telmisartan Tablets using Hydrophilic Polymers
26. March 2017 Aim: Telmisartan is an anti-hypertensive drug under the class of angiotensin II receptor blocker. The aim is to formulate and evaluated immediate release…
Formulation and Evaluation of Bosentan Solid Dispersion
26. March 2017 Aim: The therapeutic efficiency of a formulation will depend on various crucial parameters such as solubility of the drug, stability of the compound,…
Structure, functionality and applications of debranched starch: A review
26. March 2017
Background
Starchy products have been widely used in the food, paper, textile, plastic, cosmetics, adhesives, and pharmaceutical industries. To meet specific requirements of their applications,…
The application prospects and development trends of orally disintegrating tablets to dogs
25. March 2017 ABSTRACT: Orally disintegrating tablets (ODTs) disintegrate rapidly in the mouth in seconds when placed at the tongue. The introduction of ODTs for dogs…
pH responsive controlled release of anti-cancer hydrophobic drugs from sodium alginate and…
25. March 2017 Abstract Developing a drug carrier system which could perform targeted and controlled release over a period of time is utmost concern in the pharmaceutical…
Vapour-phase method in the synthesis of polymer-ibuprofen sodium-silica gel composites
25. March 2017 Abstract The study discusses the synthesis of polymer-silica composites comprising water soluble drug (ibuprofen sodium, IBS). The polymers selected for…
Physicochemical Characterization and Dissolution Study of Solid Dispersion Tablet of Azithromycin
25. March 2017 Aim: To increase the solubility of azithromycin by formulating solid dispersion (SD) and then SD tablets (SDT) were prepared from the best formulation of SDs.…
Budenheim site GMP certified for phosphate excipients
25. March 2017 Chemische Fabrik Budenheim site receives EXCiPACT GMP Certification as pharmaceutical excipient suppliers Speciality products and phosphates…
Formulation and Evaluation of Oro-Dispersible Tablets Using Modified Polysaccharides
24. March 2017 Formulation and Evaluation of Oro-Dispersible Tablets Using Modified Polysaccharides Abstract: Orodispersible tablets (ODT) of levocetirizine was prepared…
Formulation and evaluation of nasal in situ gel of phenylephrine hydrochloride
24. March 2017
Abstract
In situ gel drug delivery systems are in solution form before administration but once administered, undergo gelation in situ, to form a gel. In the present study nasal in situ gel of Phenylephrine…
Critical Material Attributes of Strip Films Loaded With Poorly Water-Soluble Drug Nanoparticles: II.…
24. March 2017 Abstract Recent work established polymer strip films as a robust platform for delivery of poorly water-soluble drug particles. However, a simple means of…
Physical modification and characterization of starch using pregelatinization and co- process of…
24. March 2017
Abstract. Starch is an economical excipient that is used in oral dosage form. It has poor compressibility and flowability. Pregelatinization and co-process as a physical modification technique…
Dry powder inhalation: past, present and future
24. March 2017 Abstract Introduction: Early dry powder inhalers (DPIs) were designed for low drug doses in asthma and COPD therapy. Nearly all concepts…
Rational excipient selection for co-amorphous formulations
24. March 2017 ABSTRACT Introduction: For almost two decades there has been intense debate about whether the amorphous solid state form could resolve the solubility…
Formulation approaches to pediatric oral drug delivery: benefits and limitations of current…
24. March 2017 Abstract Introduction: Most conventional drug delivery systems are not acceptable for pediatric patients as they differ in their developmental…
Biogrund Film Coating Excellence – Newsletter Spring 2017
24. March 2017
Highlights on
HME Cleaner Plus (GMP) - Easy cleaning of hot melt extrusion
BonuCel® - Rapid success with an easy-to-use hypromellose for pharmaceutical, food & personal care applications…