Fabrication of polymeric sorafenib coated chitosan and fucoidan nanoparticles: Investigation of anticancer activity and apoptosis in colorectal cancer cells
The most prevalent form of colon cancer also ranks high among cancer-related deaths globally. Traditional chemotherapy drugs do not provide sufficient therapeutic efficacy, and advanced colon cancer demonstrates considerable resistance to chemotherapy. As an oral kinase inhibitor, sorafenib (SOR) suppresses the growth of tumour cells, the formation…
Physicochemical and in vivo evaluation of crosslinked carboxymethyl chitosan-gelatin scaffolds for…
This study intends to fabricate new antimicrobial scaffolds based on crosslinked Carboxymethyl chitosan (CMCh)/gelatin (Gel) biopolymers. While the physical and morphological characteristics of the crosslinked scaffolds were investigated…
Enhanced oral delivery of hesperidin-loaded sulfobutylether-β-cyclodextrin/chitosan nanoparticles…
Abstract
Hesperidin (Hsd), a bioactive phytomedicine, experienced an antidiabetic activity versus both Type 1 and Type 2 Diabetes mellitus. However, its intrinsic poor solubility and bioavailability is a key challenging obstacle reflecting…
Michael Repka earns Shangraw award for study of inactive pharmaceutical ingredients
OXFORD, Miss. – University of Mississippi pharmacy professor Michael Repka has been announced as recipient of the prestigious 2023 Ralph Shangraw Memorial Award.
This recognition by the International Pharmaceutical Excipients Council…
Cyclodextrins and derivatives in drug delivery: New developments, relevant clinical trials, and…
Cyclodextrins (CD) and derivatives are functional excipients that can improve the bioavailability of numerous drugs. Because of their drug solubility improving properties they are used in many pharmaceutical products. Furthermore, the…
Evaluation of a Three-Fluid Nozzle Spraying Process for Facilitating Spray Drying of Hydrophilic…
Abstract
Amorphous solid dispersions (ASDs) enable formulations to improve the solubility of poorly soluble active pharmaceutical ingredients (APIs). The amorphous state is reached through the disruption of the crystalline lattice of an…
Curcumin-infused nanostructured lipid carriers: a promising strategy for enhancing skin regeneration…
Abstract
Background
Curcumin is a biomolecule that can be extracted from the Curcuma longa that has been shown to have the potential to aid skin wound healing. It has been studied for its anti-inflammatory and antioxidant properties,…
The Anti-Oxidant Curcumin Solubilized as Oil-in-Water Nanoemulsions or Chitosan Nanocapsules…
Abstract
The bacterium Helicobacter pylori (H. pylori) represents a major risk factor associated with the development of gastric cancer. The anti-oxidant curcumin has been ascribed many benefits to human health, including bactericidal…
Development of the Composition and Technology for Obtaining a Model of an Injection Form of an…
The indolocarbazole derivative LCS-1269 has a multitarget mechanism of action on tumors and blocks vasculogenic mimicry. The hydrophobic character of LCS-1269 hampers the development of an injectable dosage form (IDF), the need for…
Detachable-Dissolvable-Microneedle as a potent subunit vaccine delivery device that requires no…
Although vaccine administration by microneedles has been demonstrated, delivery reliability issues have prevented their implementation. Through an ex vivo porcine skin experiment, we show visual evidence indicating that detachable…
Recent advances in micro- and nano-scale carrier systems for controlled delivery of vaccines
Vaccines provide substantial safety against infectious diseases, saving millions of lives each year. The recent COVID-19 pandemic highlighted the importance of vaccination in providing mass-scale immunization against outbreaks. However, the…
Smart nano-in-microparticles to tackle bacterial infections in skin tissue engineering
Chronic wounds (resulting from underlying disease, metabolic disorders, infections, trauma, and even tumours) pose significant health problems. In this work, microparticles, based on polysaccharides (maltodextrin or dextran) and amino…
Stability study of spray freeze-dried insulin dry powder formulations used for nose-to-brain…
Insulin is classified as a cold chain product due to being a peptide hormone with stability issues in the liquid preparation. Therefore, insulin was developed into the dry powder form to improve the stability and application for…
Rational Selection of Cyclodextrins for the Solubilization of Poorly Soluble Oral Drugs
We invite you to our next webinar:
"Rational Selection of Cyclodextrins for the Solubilization of Poorly Soluble Oral Drugs"
Poorly soluble drugs for oral administration present unique formulation challenges, particularly during…
Cubosomal functionalized block copolymer platform for dual delivery of linagliptin and…
A well-made chitosan-PVP block copolymer platform was equipped with highly ordered and uniform nano-channels. This highly adhesive block copolymer platform was designed to ensure the efficient co-delivery of two synergistic-acting…
Modern Aspects of Suppositories: A Review
ABSTRACT
Suppositories are an underutilized dosage form. Suppositories are such types of dosage forms used to provide medication via the vaginal and rectal routes. Vaginal suppositories are commonly referred to as pessaries. It was…
A dry powder formulation for peripheral lung delivery and absorption of an anti-SARS-CoV-2 ACE2…
One of the strategies proposed for the neutralization of SARS-CoV-2 has been to synthetize small proteins able to act as a decoy towards the virus spike protein, preventing it from entering the host cells. In this work, the incorporation of…
Improving API Solubility – by Merck
Overview of the article
The Importance of API Solubility for Solid and Liquid Dosage Forms
The Solubilization Process
The Biopharmaceutics Classification System of APIs
The Developability Classification System
The Central…
Enhanced in vivo absorption and biodistribution of curcumin loaded into emulsions with high…
The health benefits of curcumin have been demonstrated by clinical studies, but its low bioavailability compromises its functionality. In this regard, emulsions have proven to be effective encapsulation systems for curcumin. Nevertheless,…
Nanoarchitectonics of doxycycline-loaded vitamin E–D-α-tocopheryl polyethylene glycol 1000 succinate…
Abstract
Aim:
This study aim to develop doxycycline within the D-α-tocopheryl polyethylene glycol 1000 succinate micelle platform as an anticancer stem cell agent.
Materials & methods:
The optimized nanomicelle formulation was…
Unveiling the complexation mechanism of phloretin with Sulfobutylether–β–cyclodextrin (Captisol®)…
Abstract
The incorporation of phloretin (PHL), a dihydrochalcone flavonoid, in functional foods is usually hampered by its low aqueous solubility. In this regard, we investigated the impact of complexation of PHL with…
Nanosuspensions as carriers of active ingredients: Chemical composition, development methods, and…
Nanosuspensions (NSps) are colloidal dispersions of particles that have the potential to solve the delivery problems of active ingredients associated with their low solubility in water or instability due to environmental factors. It is…
Nitrite Content In Hydroxypropyl Methylcellulose
Introduction
N-nitrosamines are considered probable or possible carcinogens according to the International Agency for Research on Cancer, an agency within the World Health Organization (1).
Regulatory bodies across the world…
Enteric-coating film effect on the delayed drug release of pantoprazole gastro-resistant generic…
Abstract
Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to…
Overcoming Challenges of Taste Masking
In a 2003 survey conducted by the American Association of Pediatrics, unpleasant taste was identified as the most significant barrier to completing treatment in pediatrics.
Drug taste masking is extremely relevant to improve patient…
Chitosan nanoparticles and based composites as a biocompatible vehicle for drug delivery: A review
The shellfish processing industry is one of the largest growing industries across the globe with a market size of around USD 62B. However, it also leads to a significant environmental issue as it produces >80,000 tons of waste shells…
Guar gum as a microbially degradable component for an oral colon delivery system based on a…
Oral colon delivery has widely been pursued exploiting naturally occurring polysaccharides degraded by the resident microbiota. However, their hydrophilicity may hinder the targeting performance. The aim of the present study was to…
A Shrewd Ingenious Approach of Oral Drug Delivery of Insulin for the Amelioration of Diabetic…
Since 1922, insulin has saved the lives of countless people. However, the difficulties of subcutaneous administration, the need for frequent glucose self-monitoring, and the non-physiological action profiles of insulin prompted many medical…
Preparation and Characterization of an Antiviral Gel
ABSTRACT
The study was to develop an antiviral gel for topical application. The topical application of drug has many advantages over the intravenous and oral administration. It prevents metabolism of drug from liver and avoid the risk of…
Spray-dried, Biodegradable, Linezolid loaded Microspheres for Use in the Treatment of Lung Diseases
ABSTRACT
Introduction: Researchers worldwide are currently seeking innovative treatment options to combat the alarming increase in bacterial resistance to antimicrobial drugs. Staphylococcus aureus, a frequently encountered and potentially…
Challenges encountered in the transfer of atorvastatin tablet manufacturing – commercial…
As is the case with batch-based tableting processes, continuous tablet manufacturing can be conducted by direct compression or with a granulation step such as dry or wet granulation included in the production procedure. In this work,…
Feasibility study of the use of a homemade direct powder extrusion printer to manufacture printed…
Among the various 3D printing techniques, FDM is the most studied in pharmaceutical research. However, it requires the fabrication of filaments with suitable mechanical properties using HME, which can be laborious and time-consuming. DPE…
Image-based simultaneous particle size distribution and concentration measurement of powder blend…
Abstract
This work presents a system, where deep learning was used on images captured with a digital camera to simultaneously determine the API concentration and the particle size distribution (PSD) of two components of a powder blend. The…
Extemporaneous preparation of paediatric oral formulations with sildenafil citrate
The paediatric population is composed of several very diferent subgroups, each with its own specifc characteristics. For this reason, children cannot be considered “small adults”. The development of formulations suitable for children is a…
The era of digital pharmacy. 3D printing – realities and perspectives
3D printing is an innovative technology for building three-dimensional objects by laying down successive layers of material under the control of a computer software. It is entering pharmacy mainly because of its revolutionary potential to…