Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Application of moisture activated dry granulation (MADG) process to develop high dose immediate…
08. March 2017 Abstract Moisture activated dry granulation (MADG) method was used to develop IR tablets with cohesive, fluffy and high dose drugs. To evaluate this…
Pharmaceutical characterization of novel tenofovir liposomal formulations for enhanced oral drug…
08. March 2017 Abstract Tenofovir, currently marketed as the prodrug tenofovir disoproxil fumarate, is used clinically to treat patients with HIV/AIDS. The oral…
Modulation of microenvironmental pH for dual release and reduced in vivo gastrointestinal bleeding…
08. March 2017 Abstract This study was designed to develop a once-daily controlled-release matrix tablet of aceclofenac 200 mg (AFC-CR) with dual release characteristics…
Amorphous is not always better—A dissolution study on solid state forms of carbamazepine
08. March 2017 Abstract Poor aqueous solubility is a major concern for many new drugs. One possibility to overcome this issue is to formulate the drug as a high energy…
Thermoplastic starch: improving their barrier properties
08. March 2017 Abstract There are several strategies for improving functional properties of starch-based materials. Blending with more hydrophobic compounds and bilayer…
Controlled release of insulin from folic acid-insulin complex nanoparticles
08. March 2017 Abstract Associative interactions between folic acid and proteins are well known. This work leverages these interactions to engineer folic acid…
Inhaled dry powder mannitol in children with cystic fibrosis: A randomised efficacy and safety trial
08. March 2017 Introduction Inhaled mannitol has beneficial effects on lung function, mucociliary clearance, quality of life and sputum properties. This…
Optimization of two biopolymer-based oral films for the delivery of bioactive molecules
08. March 2017 Abstract An experimental design was established in order to optimize the mechanical properties of two oral film formulations intended for oral delivery of…
Topiramate Extended-Release Options: A Focus onEfficacy and Safety in Epilepsy and Comorbidities
08. March 2017 ABSTRACT: Topiramate (TPM) is effective for multiple seizure types and epilepsy syndromes in children and adults. Topiramate has adverse effects…
Evaluating the Properties of Poly(lactic-co-glycolic acid) Nanoparticle Formulations Encapsulating a…
06. March 2017 Abstract We applied the Quality by Design (QbD) approach to the development of poly(lactic-co-glycolic acid) (PLGA) nanoparticle formulations encapsulating…
Orally disintegrating films focusing on formulation, manufacturing process, and characterization
06. March 2017 Abstract Orally disintegrating films (ODF) has recently become one of the most popular forms of drug administration due to its excellent patient…
Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion…
Abstract
In the present study, we aimed to prepare a gastroretentive drug delivery system that would be both highly resistant to gastric emptying via multiple mechanisms and would also potentially induce in situ supersaturation.…
Production of aprepitant nanocrystals by wet media milling and subsequent solidification
06. March 2017 Abstract The present study investigates the effects of formulation and process parameters on the production of aprepitant nanosuspensions applying wet…
Continuous directpelletization technologies and other innovative formulation solutions?
06. March 2017 Continuous directpelletization technologies and other innovative formulation solutions? Meet Glatt Pharmaceutical Services @2nd EUROPEAN CONFERENCE on…
Development and characterisation of cellulose based electrospun mats for buccal delivery of…
04. March 2017 Abstract In this study conventional electrospinning (ES) was used to prepare a series of buccal films containing indomethacin (INDO, a nonsteroidal…
The effects of HPMC concentration as a new pharmaceutical dosageform on phage release pattern from…
04. March 2017 The effects of HPMC concentration as a new pharmaceutical dosageform on phage release pattern from gels Abstract Bacterial resistance to various antibiotics…
MRI traceable protein biomaterials for drug delivery – Presentation @ ExcipientFest Americas…
04. March 2017
MRI traceable protein biomaterials for drug delivery - Presentation @ ExcipientFest Americas 2017
ABSTRACT: Through centuries of evolution, nature has developed biopolymers capable of folding and…
Preparation of 200 mg fenofibrate hard capsule with high dissolution profile with microparticle…
03. March 2017 Abstract Fenofibrate, a drug of fibrate class, is mainly used to reduce cholesterol levels in patients at risk of cardiovascular disease. However,…
Characterising Drug Release from Immediate-Release Formulations of a Poorly Soluble Compound,…
03. March 2017 Abstract The study aimed to characterise the mechanism of release and absorption of Basmisanil, a biopharmaceutics classification system (BCS) class 2…
Optimization of formulation processes using Design Expert® Software for preparation of polymeric…
03. March 2017 AbstractA 23 Factorial design of cissus-gelatin B polymer blends was developed to formulate amodiaquineHCl-artesunate (AQ-AS) microparticles by varying the…
Managing the delicate balance between Purchasing Strategy and Quality Requirements –…
03. March 2017 Managing the delicate balance between Purchasing Strategy and Quality Requirements - Presentation @ ExcipientFest Americas 2017…
Multivariate analysis to enable product understanding in a QbD era – Presentation @…
03. March 2017 Multivariate analysis to enable product understanding in a QbD era - Presentation @ ExcipientFest Americas 2017 ABSTRACT: In the…
Manufacturing of biocompatible porous titanium scaffolds using a novel spherical sugar pellet space…
02. March 2017 Abstract A new and highly biocompatible space holder material is proposed for manufacturing of porous titanium with open and interconnected pore…
A novel approach in mucoadhesive drug delivery system to improve zidovudine intestinal permeability
02. March 2017
Zidovudine (AZT) mucoadhesive solid dispersions (SD) were prepared using a sodium starch glycolate (SSG) and hypromellose phthalate (HPMCP) mixtures as carrier to enhance the intestinal permeability…
The Development of Self-nanoemulsifying Liquisolid Tablets to Improve the Dissolution of Simvastatin
02. March 2017
Abstract
The aim of this work was to develop self-nanoemulsifying liquisolid tablets (SNELT) to enhance the dissolution profile of poorly water-soluble simvastatin. SNELT present a unique technique of…
Swiss Pharma Science Day 2017 – 10th Anniversary
02. March 2017 High-Class Presentations, Posters and meeting point of Master and PhD students, as well as Post-Docs of all the three Swiss Academic…
A pragmatic approach to Atypical Actives – Presentation @ ExcipientFest Americas 2017
02. March 2017 A pragmatic approach to Atypical Actives - Presentation @ ExcipientFest Americas 2017 ABSTRACT: How are atypical actives being…
Direct compressible excipients for ODT formulations: comparison of traditional and innovative…
02. March 2017 Direct compressible excipients for ODT formulations: comparison of traditional and innovative solution - Presentation @ ExcipientFest Americas 2017…
Development of a Process Analytical Technology(PAT) method using near-infrared spectroscopy system…
01. March 2017
Abstract
The purpose of the present study was to develop a near-infrared spectroscopy (NIRS) method to quickly, accurately, and precisely evaluate and control the coating process of the low dose drug,…
Optimization of self-nanoemulsifying formulations for weakly basic lipophilic drugs: role of…
01. March 2017 ABSTRACT Formulators face great challenges in adopting systematic approaches for designing self-nanoemulsifying formulations (SNEFs) for different drug…
Materials for use in formulating combination products – Presentation @ ExcipientFest Americas…
01. March 2017 Materials for use in formulating combination products - Presentation @ ExcipientFest Americas 2017 ABSTRACT: How are atypical actives…
Multiples Uses of Poloxamer 188 – Presentation @ ExcipientFest Americas 2017
01. March 2017 Multiples Uses of Poloxamer 188 - Presentation @ ExcipientFest Americas 2017 ABSTRACT: The goal of this presentation is to discuss…
3D Printing in Drug Product Development
28. February 2017
BY: ASHLEY JOHNSON
Recently, there has been increasing interest in using 3D printing (3DP) to manufacture drug products. Notably, in 2015, the Food and Drug Administration (FDA) approved the first…
Effects of excipients and curing process on the abuse deterrent properties of directly compressed…
28. February 2017 Abstract The objective of the present investigation was to understand the effects of excipients and curing process on the abuse deterrent properties…