Relaxation tests for the time dependent behavior of pharmaceutical tablets: A revised interpretation
Relaxation tests are often used in the pharmaceutical field to assess the strain rate sensitivity of pharmaceutical powders and tablets. These tests involve applying a constant strain to the powder in the die and then monitoring the stress evolution over time. Interpreting these tests is complicated because different physical phenomena, mainly…
Organic Taste Modulation (Bitterblock): Improved tastemasking with less sugar – Presentation @…
28. February 2017 Organic Taste Modulation (Bitterblock): Improved tastemasking with less sugar - Presentation @ ExcipientFest Americas 2017…
USP Update on excipient standard setting activities – the importance of stakeholder engagement with…
28. February 2017 USP Update on excipient standard setting activities – the importance of stakeholder engagement with USP - Presentation @ ExcipientFest Americas 2017…
For Lyophilization, Excipients Really Do Matter
27. February 2017 Excipient selection strongly influences lyophilization performance for biologic drugs Lyophilization, or freeze drying, is a well-recognized…
Process Analysis and Optimization of Continuous Pharmaceutical Manufacturing using Flowsheet Models
27. February 2017 Abstract Continuous manufacturing has attracted increasing research attention in the pharmaceutical industry within the last decade. Based on the…
Influence of Chitosan Swelling Behaviour on Controlled Release of Tenofovir from Mucoadhesive…
27. February 2017 Abstract: The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education…
Potential of single cationic amino acid molecule “Arginine” for stimulating oral absorption of…
27. February 2017 Abstract We have reported that cell-penetrating peptides, such as oligoarginine, act as powerful absorption enhancers for the development of oral…
Enhanced pulmonary absorption of poorly soluble itraconazole by micronized cocrystal dry powder…
27. February 2017 Abstract Micronized cocrystal powders and amorphous spray-dried formulations were prepared and evaluated in vivo and in vitro as pulmonary absorption…
Assessment of different polymers and drug loads for fused deposition modeling of drug loaded…
27. February 2017 Abstract The 3D printing technique of fused deposition modeling® (FDM) has lately come into focus as a potential fabrication technique for…
Thermo-responsive polymers and their application as smart biomaterials
27. February 2017 The drastic development of polymeric materials for a wide range of biomedical and biomaterial applications has been explored in the last few decades. Among…
An extensive compatibility study of mycophenolate mofetil with different excipients by spectroscopic…
27. February 2017 Abstract Mycophenolate mofetil is used as an immunosuppressive agent to prevent acute rejection of transplanted organs. Mycophenolate mofetil is rapidly…
Novel Docusate Excipients for Poorly Soluble APIs – Presentation @ ExcipientFest Americas 2017
27. February 2017 ABSTRACT: Docusate, a surfactant for the pharmaceutical market, has been demonstrated to be an outstanding solubilizing agent for poorly…
Application of halloysite clay nanotubes as a pharmaceutical excipient
25. February 2017 Abstract Halloysite nanotubes, a biocompatible nanomaterial of 50–60 nm diameter and ca. 15 nm lumen, can be used for loading, storage and sustained…
The SeDeM expert diagram system: its performance and predictability in direct compressible…
25. February 2017 Abstract The SeDeM Expert Diagram System is a galenic pre-formulation system, which evaluates the suitability of excipients and active pharmaceutical…
Powder properties and compaction parameters that influence punch sticking propensity of…
25. February 2017 Abstract Punch sticking is a frequently occurring problem that challenges successful tablet manufacturing. A mechanistic understanding of the punch…
Solidification of liquid self-emulsifying lipid formulationsby loading on solid mesoporous carriers
24. February 2017 Solidification of liquid self-emulsifying lipid formulationsby loading on solid mesoporous carriers Lipid-based formulations (LBFs) can be effective drug…
Role of dwell on compact deformation during tableting: an overview
23. February 2017 Abstract Tablet compaction is an important unit operation in the pharmaceutical industry. Among the compaction parameters, dwell time is a key parameter…
Anhui’s Chinese site receives ExciPact GMP certification as excipient suppliers
23. February 2017 Brussels, 21 February 2017 EXCiPACT…
Effect of Different Meltable Binders on the Disintegration and Dissolution Behavior of Zolmitriptan…
22. February 2017
Abstract
Objective: Fast melt tablets and sublingual route have been widely used for providing quick onset of action with the avoidance of first pass metabolism. The objective of this work was to compare…
Assessment of physical properties of granules with paracetamol and caffeine
22. February 2017 Abstract Caffeine increases the analgesic properties of acetaminophen and therefore it is reasonable to use both substances together in one drug form in…
Innovative “Hydrochlorothiazide-in Cyclodextrins-in Solid Lipid Nanoparticles” formulation with…
22. February 2017 Abstract An innovative pediatric oral formulation of hydrochlorothiazide (HCT) (2 mg/mL), endowed with improved bioavailability and sustained release…
Medicated Multiple-component Polymeric Nanocomposites Fabricated Using Electrospraying.
22. February 2017
Abstract:
Drug-loaded hydrophilic polymeric composite (HPC) is one of the most promising biomaterials for resolving the long-standing challenge of the development of oral solid formulations for insoluble…
Medicines for children: flexible, solid, oral formulations
22. February 2017 Children younger than five years old are generally unable to safely swallow solid capsules and tablets larger than 10 mm.1 Although oral liquid medicines…
Advances in hot-melt extrusion technology toward pharmaceutical objectives
22. February 2017 Hot Melt Extrusion (HME) technology is a widely used for manufacturing process in the plastic and pharmaceutical industries and is an efficient and simple…
Effect of cyclophosphamide on the solid form of mannitol during lyophilization
22. February 2017 Abstract Mannitol is a commonly used bulking agent in lyophilized formulations. It can crystallize into multiple solid forms during lyophilization…
Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution,…
21. February 2017 Abstract: The aim of this work was to develop cefdinir solid dispersions (CSDs) prepared using hydrophilic polymers with enhanced dissolution/solubility…
Microencapsulation of fish oil using supercritical antisolvent process
21. February 2017 Abstract In order to improve the encapsulation process, a newly supercritical antisolvent process was developed to encapsulate fish oil using…
Preparation and Evaluation of Fast Dissolving Buccal Thin Films of Bufotenin
21. February 2017 Abstract The present investigation was undertaken with the objective of formulating Bufotenin for rapid dissolution of drug and absorption which may…
Identifying overarching excipient properties towards an in-depth understanding of process and…
20. February 2017
Abstract
The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge…
Solid state behavior of progesterone and its release from Neusilin US2 based liquisolid compacts
20. February 2017 Abstract The aim of present work was to investigate the role of liquisolid technique in improving dissolution of high dose Progesterone.…
An investigation into moisture barrier film coating efficacy and its relevance to drug stability in…
20. February 2017 Abstract Barrier coatings are frequently employed on solid oral dosage forms under the assumption that they prevent moisture sorption into tablet cores…
Continuous monitoring of API content, API distribution and crushing strength after tableting via…
20. February 2017 Abstract Near-infrared chemical imaging (NIR-CI) with high-speed cameras based on the push-broom acquisition principle is a rapidly-evolving and can be…
Development of solid SEDDS, VI: Effect of precoating of Neusilin® US2 with PVP on drug release from…
20. February 2017
Abstract
Adsorption of lipid-based formulations, which are usually liquid, onto silicas has been extensively investigated in the past decade to convert them into solid dosage forms. There are conflicting…
Formulation and pharmaceutical development of quetiapine fumarate sustained release matrix tablets…
20. February 2017 The main objective of the present study was to apply QbD methodology in the development of once-a-day sustained release quetiapine tablets. The…
FDA’s 2016 Approvals of New Drugs, Formulations, Strengths & More
20. February 2017
FDA’s 2016 Approvals of New Drugs, Formulations, Strengths & More
After 2 years of sky-high approval numbers, the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and…